Flow injection analysis for the photometric determination of promethazine-HCl in pure and pharmaceutical preparation via oxidation by persulphate using Ayah 3SX3-3D solar micro photometer

The first flow injection spectrophotometric method is characterized by its speed and sensitivity which have been developed for the determination of promethazine-HCl in pure and pharmaceutical preparation. It is based on the in situ detection of colored cationic radicals formed via oxidation of the drug with sodium persulphate to pinkish-red species and the same species was determined by using homemade Ayah 3SX3-3D solar flow injection photometer. Optimum conditions were obtained by using the high intensive green light emitted diode as a source. Linear dynamic range for the absorbance versus promethazine-HCl concentration was 0-7 mmol.L-1, with the correlation coefficient (r) was 0.9904 while the percentage linearity (r2%) was 98.09%. the L.O.Q was 3.97 µg/sample, while L.O.D (S/N=3) = 0.2407µg/sample (5 µmol.L-1) from the stepwise dilution for the minimum concentration of lowest concentration in the linear dynamic range of the calibration graph. The R.S.D% at 2 mmol.L-1 promethazine-HCl is less than 1% (eight replicates) using 150 µL sample volume. Throughput 30 sample.hr-1. The method was applied successfully for the determination of promethazine-HCl in pharmaceutical preparation. By using paired t-test it was shown that there was no significant difference between the proposed method and official method and on that basis the new method can be accepted as an alternative analytical method

Hydrogen Bonds Effects on the Electrical Properties of Pectin/Pva Graphene Nanocomposites

Electrical properties were studied for Pectin/PVA graphene composites films and the effect of aqueous interaction on their properties. The conductivity and the dielectric constant of this composite are important because Polysaccharide like pectin is increasingly being used in biomedical applications and as nanoparticles coating materials. The Dielectric and conductivity of composite films were compared in dry and wet condition the differences in the results were attributed to the water molecules and the hydrogen bond which connect the three composite compounds (Pectin, PVA and Graphene) together. These connections were allowed the hydrogen and hydroxyl group’s migrations in the composite super molecules. On the other hand, graphene was prepared and with different techniques like Ft-IR, XRD, SEM and AFM characterized. Keywords: Hydrogen Bonds, nanocomposite , dielectric constant , Pectin/PVA graphene nanocomposit

Les tumeurs malignes primitives de l'intestin grêle: aspects cliniques et thérapeutiques de 27 patients

Les tumeurs malignes de l'intestin grêle (TMPIG) sont des tumeurs rares. Elles représentent 1 à 5% de toutes les tumeurs du tube digestif. Elles sont caractérisées par une hétérogénéité anatomopathologique et une symptomatologie pauvre et non spécifique entrainant ainsi un retard diagnostic, des difficultés Thérapeutiques et donc un mauvais pronostic. Nous rapportant les caractéristiques épidémiologiques, diagnostiques et thérapeutiques ainsi que la survie des patients atteints des TMIG au sein de l’institut national d’oncologie de Rabat. Il s’agit d’une analyse rétrospective des dossiers cliniques des 27 patients ayant le diagnostic de tumeurs malignes de l’intestin grêle admis dans notre institut entre 1998 et 2002. L’âge médian était de 46 ans (15-70 ans). Le délai médian de diagnostic était de 6 mois (0-96 mois). La douleur abdominale était le symptôme le plus fréquent (77.8%). L’étude anatomopathologique a montré 63% de lymphome non Hodgkinien, 14.8% d’adénocarcinome, 7.4% de tumeur stromale, 7.4% de carcinome neuroendocrine et 7.4% de sarcome intestinal. Vingt patients (76. 9%) ont eu une résection chirurgicale et 14 patients (53. 8%) ont eu une chimiothérapie en fonction du stade de la maladie et du type histologique. Après un recul médian de 11.6 mois, la survie globale après 12 mois était de 44.4% et la médiane de survie était de 11.6 mois. Les tumeurs malignes de l’intestin grêle sont rares. Leur diagnostic est tardif limitant ainsi la prise en charge thérapeutique curative. Les cliniciens doivent être avertis des symptômes gastro-intestinaux non spécifiques.Key words: Intestin grêle, tumeur maligne, diagnostic, chirurgie, chimiothérapie, survie, Maro

Large Negative Poisson\u27s Ratio and Anisotropic Mechanics in New Penta-PBN Monolayer

The scarce negative Poisson\u27s ratio (NPR) in a two-dimensional (2D) material is an exceptional auxetic property that offers an opportunity to develop nanoscale futuristic multi-functional devices and has been drawing extensive research interest. Inspired by the buckled pentagonal iso-structures that often expose NPR, we employ state-of-the-art first-principles density functional theory calculations and analyses to predict a new 2D metallic ternary auxetic penta-phosphorus boron nitride (p-PBN) with a high value of NPR. The new p-PBN is stable structurally, mechanically, and dynamically and sustainable at room temperature, with experimental feasibility. The short and strong quasi sp3-hybridized B-N bond and unique bond variation and geometrical reconstruction with an applied strain allow p-PBN to inherit a high value of NPR (-0.236) along the (010) direction, the highest among any other ternary penta iso-structures reported to date. Despite having a small elastic strength, the highly asymmetric Young\u27s modulus and Poisson\u27s ratio along the (100) and (010) directions indicate large anisotropic mechanics, which are crucial for potential applications in nanomechanics and nanoauxetics

Hernie obturatrice étranglée: à propos de deux cas

La hernie obturatrice (HO) est rare. Elle est à l'origine de 0,2 à 1,6% des occlusions mécaniques de l'intestin grêle avec un taux de mortalité etmorbidité après chirurgie est respectivement de 35 et 18%. Nous rapportons le cas de deux patientes chez qui le diagnostic de HO étranglée est établie dans le cadre du bilan d'une occlusion. La HO est une entité dont le diagnostic préopératoire est difficile en raison de la faible spécificité clinique. L'examen tomodensitométrique semble être une aide majeure au diagnostic  étiologique. Mais une fois le diagnostic d'occlusion posé, une intervention en urgence permettra d'en préciser l'étiologie et d'en réaliser le traitement. Tout retard thérapeutique majore la mortalité et la morbidité

Prostate cancer metastases to the rectum: A case report

Prostate cancer rarely metastasis to the rectum. Findings in the patient reported here emphasize the importance of the relationship between urinary and gastrointestinal symptoms in detecting prostatic neoplasms in older male patients

Audit on Environmental Sustainability of Accounting Activities and Its Impact on Maximizing the Value of the Enterprise as a Framework Proposed by the Auditors

The main objective of this study is to clarify the relation between the review of environmental sustainability accounting for Palestinian enterprises and the value of these establishments in general, and then determine the responsibility of the external auditor for the audit of environmental sustainability accounting activities and clarify its role in environmental community conservation. The questionnaire was used as a tool to be distributed in a comprehensive survey to 150 auditors of the accounting and auditing profession according to the disclosure of an annex from the Palestinian Accountants and Auditors Association. 120 responses were recovered with 80% recovery rate. The researchers found a positive correlation between the "audit on environmental sustainability accounting activities and the value of the enterprise" and in the same direction, it is clear that any change in the audit of environmental sustainability accounting activities is followed by a change in the value of the enterprise and in the same direction, and that any change in the proposed framework for the audit of environmental sustainability accounting activities is followed by a change in the value of the enterprise and in the same direction. The researchers recommended the issuance of legislation and criteria for the adoption of the audit on activities of environmental sustainability accounting and the adoption of the framework proposed by the higher authorities and recommend the application of them at the level of Palestinian enterprises, and the need to adopt them as part of the curriculum approved by university colleges. Keywords: Environmental Auditing, Environmental Sustainability Accounting, Maximizing the Value of the Establishment, Auditors and Auditors, Gaza Strip, Palestine

Synthesis and Characterizations of Bare CdS Nanocrystals Using Chemical Precipitation Method for Photoluminescence Application

Bare cadmium sulfide (CdS) nanocrystals were successfully synthesized by the thermolysis of a single-source organometallic precursor, cadmium chloride hemipentahydrate (CdCl2⋅2.5H2O) with thiourea in ethanol. The microstructure of the CdS samples was characterized using XRD, TEM, and Raman spectroscopy. The XRD's results showed that there was a transformation from cubic to hexagonal crystalline phase when higher mass of CdCl2⋅2.5H2O was used. Further experimental with different Cd2+ source showed ion Cl− originated from CdCl2⋅2.5H2O attributed to this crystalline phase transformation. The UV-Visible analysis indicated that quantum confinement effect took place when compared to the bulk CdS. However, the photoluminescence experiments revealed that the red-light emission was observed in all samples. This finding could be ascribed to deep trap defects that were due to sulfur vacancies as suggested by XPS and also the fact that the bare CdS nanoparticles are in contact with each other as shown in the TEM images

Adrenergic gene polymorphisms and cardiovascular risk in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation

<p>Abstract</p> <p>Background</p> <p>Adrenergic gene polymorphisms are associated with cardiovascular and metabolic phenotypes. We investigated the influence of adrenergic gene polymorphisms on cardiovascular risk in women with suspected myocardial ischemia.</p> <p>Methods</p> <p>We genotyped 628 women referred for coronary angiography for eight polymorphisms in the α_1A-, β₁-, β₂- and β₃-adrenergic receptors (<it>ADRA1A</it>, <it>ADRB1, ADRB2</it>, <it>ADRB3</it>, respectively), and their signaling proteins, G-protein β 3 subunit (<it>GNB3</it>) and G-protein α subunit (<it>GNAS</it>). We compared the incidence of death, myocardial infarction, stroke, or heart failure between genotype groups in all women and women without obstructive coronary stenoses.</p> <p>Results</p> <p>After a median of 5.8 years of follow-up, 115 women had an event. Patients with the <it>ADRB1 </it>Gly389 polymorphism were at higher risk for the composite outcome due to higher rates of myocardial infarction (adjusted hazard ratio [HR] 3.63, 95% confidence interval [95%CI] 1.17–11.28; Gly/Gly vs. Arg/Arg HR 4.14, 95%CI 0.88–19.6). The risk associated with <it>ADRB1 </it>Gly389 was limited to those without obstructive CAD (n = 400, P_interaction= 0.03), albeit marginally significant in this subset (HR 1.71, 95%CI 0.91–3.19). Additionally, women without obstructive CAD carrying the <it>ADRB3 </it>Arg64 variant were at higher risk for the composite endpoint (HR 2.10, 95%CI 1.05–4.24) due to subtle increases in risk for all of the individual endpoints. No genetic associations were present in women with obstructive CAD.</p> <p>Conclusion</p> <p>In this exploratory analysis, common coding polymorphisms in the β₁- and β₃-adrenergic receptors increased cardiovascular risk in women referred for diagnostic angiography, and could improve risk assessment, particularly for women without evidence of obstructive CAD.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov NCT00000554.</p