MULTI-MODALITY IMAGING IN AORTIC STENOSIS:AN EACVI CLINICAL CONSENSUS DOCUMENT

International audienceIn this EACVI clinical scientific update, we will explore the current use of multi-modality imaging in the diagnosis, risk stratification, and follow-up of patients with aortic stenosis, with a particular focus on recent developments and future directions. Echocardiography is and will likely remain the key method of diagnosis and surveillance of aortic stenosis providing detailed assessments of valve haemodynamics and the cardiac remodelling response. Computed tomography (CT) is already widely used in the planning of transcutaneous aortic valve implantation. We anticipate its increased use as an anatomical adjudicator to clarify disease severity in patients with discordant echocardiographic measurements. CT calcium scoring is currently used for this purpose; however, contrast CT techniques are emerging that allow identification of both calcific and fibrotic valve thickening. Additionally, improved assessments of myocardial decompensation with echocardiography, cardiac magnetic resonance, and CT will become more commonplace in our routine assessment of aortic stenosis. Underpinning all of this will be widespread application of artificial intelligence. In combination, we believe this new era of multi-modality imaging in aortic stenosis will improve the diagnosis, follow-up, and timing of intervention in aortic stenosis as well as potentially accelerate the development of the novel pharmacological treatments required for this disease

Evidence for the biosynthesis of DHEA from cholesterol by first-trimester human placental tissue: Source of androgens

Hormone and Metabolic Research343116-120HMMR

Cord plasma α-fetoprotein values and neonatal jaundice

Pediatrics7461065-1068PEDI

The effect of a levonorgestrel-releasing intrauterine system on angiogenic growth factors in the endometrium

10.1093/humrep/deg329Human Reproduction1891809-1819HURE

Ability of male trans-sexual testes to utilize 1,2,6,7-[3H]-dehydroepiandrosterone for [3H]-testosterone synthesis in vitro

Medical Science Research1719807-809MSCR

Resistance to Fas-mediated cell death in BeWo and NJG choriocarcinoma cell lines: Implications in immune privilege

10.1016/S0090-8258(03)00396-2Gynecologic Oncology91189-100GYNO

Expression and secretion of the vascular cell adhesion molecule-1 in human placenta and its decrease in fetal growth restriction

10.1016/S1071-5576(03)00121-7Journal of the Society for Gynecologic Investigation106352-360JSGI

Co-expression of Fas (APO-1, CD95)/Fas ligand by BeWo and NJG choriocarcinoma cell lines

10.1016/S0090-8258(03)00397-4Gynecologic Oncology911101-111GYNO

A pregnenolone → progesterone → testosterone pathway in testicular tissue from male trans-sexuals

Medical Science Research239613-615MSCR