381pdcomprehensive geriatric assessment cga for outcome prediction in elderly patients pts with glioblastoma gbm a mono institutional experience

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Complement system and the brain: selected pathologies and avenues toward engineering of neurological nanomedicines

Several nanoparticle systems and supramolecular assemblies are under investigation as potential therapeutic entities for Alzheimer's disease and other neurological disorders through both brain-specific targeting and peripheral effects. However, activation of the complement system, a complex innate immune network of over 30 circulating and membrane-bound proteins, remains a serious concern related to the use of these prospective neurological nanomedicines. The role of complement in processes of neurodegeneration in the injured or aged and diseased central nervous system is well known. Nanoparticle-mediated complement activation cannot only induce adverse cardiopulmonary distress in sensitive subjects, but may further aggravate the already-compromised condition of neurological disorders and diseases. This minireview briefly examines the role of complement in neurological diseases and outlines the current status of the development of key neurological nanomedicines with respect to complement activation. Understanding of these topics is crucial for rational design and development of safe neurological nanomedicines

THE AURORA EXPERIMENT: OVERVIEW AND PRELIMINARY RESULTS

AURORA-Stratosphere and Magnetic Field Polar Explorer is a student experiment from the Scuola di Ingegneria Aerospaziale of the Sapienza, University of Rome. This experiment flown on board the stratospheric balloon BEXUS-7 in the framework of the educational program REXUS-BEXUS (Rocket and Balloon Experiments for University Students) of the European Space Agency (ESA) in order to allow students to participate in all phases of a real mission, starting from the proposal through the mission requirements definition, design, building and ground test campaign, and ending with data analysis and presentation of the results. The results of the preliminary thermal tests performed in the laboratory of the Group of Astrodynamics of the Sapienza, University of Roma (GAUSS) have been compared with those obtained performing thermal-vacuum tests at the Mechanical System Laboratory (TEC-MCV) of ESA-ESTEC in Nordwijk (The Netherlands). The data analysis and results of the AURORA experiment have been presented in the paper