Electromagnetic characterisation of conductive 3D-Printable filaments for designing fully 3D-Printed antennas

Additive manufacturing (AM) 3D-printing technology is increasingly bringing benefits even in electromagnetics, with interesting prospects of application. Apart from the use of additive manufacturing for realising dielectric components of suitably shaped antennas, the ambitious target is, undoubtedly, the fully 3D realisation of radiofrequency and microwave circuits as well as radiating structures, including, therefore, conductive parts. In this regard, 3D-printable filaments with interesting conductive properties are being produced. However, their rigorous conductivity characterisation is still missing, making it difficult to estimate the real behaviour of the final 3D printed electromagnetic device. To fill this gap, the conductivity of one of the most interesting conductive filaments, named Electrifi, is first experimentally evaluated in a frequency range as large as 0.72-6 GHz, accounting also for its roughness. Then it has been validated by designing, realising, and testing three fully 3D-printed antennas. Specifically, two bow-tie antennas, operating at 2.8 and 4 GHz, respectively, and an ultrawideband antenna, borrowed from the existing literature, operating between 1 and 7 GHz. The good agreement between simulated and measured results demonstrates the reliability of the performed electrical conductivity characterisation, even in the design of efficient radiating structures entirely realised with thermoplastic materials with copper nanoparticle additives

Evaluating the Effectiveness of Planar and Waveguide 3D-Printed Antennas Manufactured Using Dielectric and Conductive Filaments

3D printing is a technology suitable for creating electronics and electromagnetic devices. However, the manufacturing of both dielectric and conductive parts in the same process still remain a challenging task. This study explores the combination of 3D printing with traditional manufacturing techniques for antenna design and fabrication, giving the designer the advantage of using the additive manufacturing technology only to implement the most critical parts of a certain structure, ensuring a satisfying electromagnetic performance, but limiting the production cost and complexity. In the former part of the study, the focus is on three proximity-coupled patch antennas. It demonstrates how hybrid devices made of metal, dielectric, and 3D-printed (using Fused Filament Fabrication) conductive polymers can be successfully simulated and created for different operating frequency bands. In the latter part, the study compares three prototypes of a 5G-NR, high gain, and wideband waveguide antenna: respectively a fully 3D printed one made of electrifi (which is the most conductive commercial 3D-printable filament), an all-metal one, and a hybrid (3D-printed electrifi & metal) one. The results show a 15% reduction in efficiency when using the all-Electrifi configuration compared to all-metal one, and a 4-5% reduction when using the hybrid version

Electromagnetic characterisation of conductive 3D-Printable filaments for designing fully 3D-Printed antennas

Additive manufacturing (AM) 3D-printing technology is increasingly bringing benefits even in electromagnetics, with interesting prospects of application. Apart from the use of additive manufacturing for realising dielectric components of suitably shaped antennas, the ambitious target is, undoubtedly, the fully 3D realisation of radiofrequency and microwave circuits as well as radiating structures, including, therefore, conductive parts. In this regard, 3D-printable filaments with interesting conductive properties are being produced. However, their rigorous conductivity characterisation is still missing, making it difficult to estimate the real behaviour of the final 3D printed electromagnetic device. To fill this gap, the conductivity of one of the most interesting conductive filaments, named Electrifi, is first experimentally evaluated in a frequency range as large as 0.72–6 GHz, accounting also for its roughness. Then it has been validated by designing, realising, and testing three fully 3D-printed antennas. Specifically, two bow-tie antennas, operating at 2.8 and 4 GHz, respectively, and an ultrawideband antenna, borrowed from the existing literature, operating between 1 and 7 GHz. The good agreement between simulated and measured results demonstrates the reliability of the performed electrical conductivity characterisation, even in the design of efficient radiating structures entirely realised with thermoplastic materials with copper nanoparticle additives

Microwaves as Diagnostic Tool for Pituitary Tumors: Preliminary Investigations

To date, tumors, the second cause of death worldwide, are a modern medicine plight. The development of rapid, cost-effective and reliable prevention and diagnostics tools is mandatory to support clinicians and ensure patients' adequate intervention. Pituitary tumors are a class of neoplasm, which calls for suitable and ad hoc diagnostic tools. Recently, microwaves have gained interest as a non-ionizing, non-invasive valuable diagnostic approach for identifying pathologic tissues according to their dielectric properties. This work deals with the preliminary investigation of the feasibility of using microwaves to diagnose pituitary tumors. In particular, it focuses on benign tumors of the adenohypophysis, e.g., the pituitary adenomas. It is assumed to access the region of interest of the pituitary region by following a trans-sphenoidal approach. The problem was modeled by developing an equivalent transmission line model of the multi-layered, lossy tissues (front bone of sphenoid sinuses, air in the sinuses, posterior bone of sphenoid sinuses, the pituitary gland and the tumor). The forward problem was developed to investigate the transmission coefficient for identifying the most favorable propagation conditions. Then, it was analyzed if, by the solution of an inverse problem, it is possible to reconstruct the permittivity and electrical conductivity profiles and identify the tumor presence. The results are promising since a maximum reconstruction error of 8% is found, in the worst case, thus paving the way for the use of microwaves for the diagnosis of pituitary tumors

Prognostic factors and treatment-effect modifiers in spinal muscular atrophy

Spinal muscular atrophy (SMA) is a rare, progressive neuromuscular disease characterized by loss of motor neurons and muscle atrophy. Untreated infants with Type 1 SMA do not achieve major motor milestones, and death from respiratory failure typically occurs before 2 years. Individuals with Types 2 and 3 SMA exhibit milder phenotypes and have better functional and survival outcomes. Herein, a systematic literature review was conducted to identify factors that influence the prognosis of Types 1, 2 and 3 SMA. In untreated infants with Type 1 SMA, absence of symptoms at birth, a later symptom onset and a higher survival of motor neuron 2 (SMN2) copy number are all associated with increased survival. Disease duration, age at treatment initiation and, to a lesser extent, baseline function were identified as potential treatment-modifying factors for survival, emphasizing that early treatment with disease-modifying therapies (DMT) is essential in Type 1 SMA. In patients with Types 2 and 3 SMA, factors considered prognostic of changes in motor function were SMN2 copy number, age and ambulatory status. Individuals aged 6-15 years were particularly vulnerable to developing complications (scoliosis and progressive joint contractures) which negatively influence functional outcomes and may also affect the therapeutic response in patients. Age at the time of treatment initiation emerged as a treatment-effect modifier on the outcome of DMTs. Factors identified in this review should be considered prior to designing or analyzing studies in an SMA population, conducting population matching or summarizing results from different studies on the treatments for SMA

An outlook on modern and sustainable approaches to the management of grape pomace by integrating green processes, biotechnologies and advanced biomedical approaches

Grape pomace is the main solid residue of wine industry, mainly composed of seeds, skins and stalks, all containing high amounts of valuable phytochemicals. Considering its high potential, in this review, an outlook on different resources and products, which can be obtained by the recovery of grape pomace is provided. Special attention has been devoted to the analysis of chemical, physical and biotechnological processes to be applied and also to the high value compounds and products, such as supplements, nutraceuticals and cosmeceuticals, that can be manufactured. In particular, in the first part of the review, an update on the composition of grape pomace has been provided along with the analysis of its traditional fate. In the second part, the more modern and green approaches tested to the sustainable management of grape pomace are reported and discussed

Space Debris Detection in Low Earth Orbit with the Sardinia Radio Telescope

Space debris are orbiting objects that represent a major threat for space operations. The most used countermeasure to face this threat is, by far, collision avoidance, namely the set of maneuvers that allow to avoid a collision with the space debris. Since collision avoidance is tightly related to the knowledge of the debris state (position and speed), the observation of the orbital debris is the key of the problem. In this work a bistatic radar configuration named BIRALET (BIstatic RAdar for LEO Tracking) is used to detect a set of space debris at 410 MHz, using the Sardinia Radio Telescope as the receiver antenna. The signal-to-noise ratio, the Doppler shift and the frequency spectrum for each debris are reported

Longitudinal changes in respiratory and upper limb function in a pediatric type III spinal muscular atrophy cohort after loss of ambulation

Introduction/Aims: Spinal muscular atrophy (SMA) type III is a relatively mild form of SMA. Few studies have investigated the changes in both respiratory and upper limb function within this population after loss of ambulation. The aim of this study was to assess change in percentage of predicted forced vital capacity (FVC% predicted) and change in the Revised Upper Limb Module (RULM) score in these patients throughout a 24-month period after loss of ambulation. Effect of scoliosis and its surgical correction, disease duration since loss of ambulation, weight, and height were also investigated. / Methods: Retrospective analyses were performed on 24 nonambulant SMA III patients from data collected at two centers in the United Kingdom. / Results: The FVC% predicted score showed a significant progressive deterioration of 17% over the 24-month period. Respiratory deterioration correlated significantly with age, weight, disease duration since loss of ambulation, and spinal correctional surgery. Longitudinal RULM data were available for 16 patients; a significant deterioration was observed with a mean decrease in score of 3 over 24 months. Age correlated negatively with RULM score, as did height and time since loss of ambulation. A significant positive correlation between FVC% predicted and RULM was demonstrated. / Discussion: This study highlights how SMA type III patients have progressive deterioration of respiratory and upper limb function after loss of ambulation. Combining data from these assessments could provide insight into clinical progression, inform clinical trials, and provide assistance in managing disease progression expectations for patients

Extraction of the antioxidant phytocomplex from wine-making by-products and sustainable loading in phospholipid vesicles specifically tailored for skin protection

The present study is aimed at valorizing grape pomace, one of the most abundant winery-making by-products of the Mediterranean area, through the extraction of the main bioactive compounds from the skin of grape pomace and using them to manufacture innovative nanoformulations capable of both avoiding skin damages and promoting skincare. The phytochemicals were recovered through maceration in hydroethanolic solution. Catechin, quercetin, fisetin and gallic acid, which are known for their antioxidant power, were detected as the main compounds of the extract. Liposomes and phospholipid vesicles modified with glycerol or Montanov 82® or a combination of both, were used as carriers for the extract. The vesicles were small (~183 nm), slightly polydispersed (PI ≥ 0.28), and highly negatively charged (~−50 mV). The extract was loaded in high amounts in all vesicles (~100%) irrespective of their composition. The antioxidant activity of the extract, measured by using the DPPH (2,2-Diphenyl-1-picrylhydrazyl) test, was 84 ± 1%, and slightly increased when loaded into the vesicles (~89%, P < 0.05). The grape pomace extract loaded vesicles were highly biocompatible and able to protect fibroblasts (3T3) from the oxidative stress induced by hydrogen peroxide