557 research outputs found
The distance to the young cluster NGC 7129 and its age
The dust cloud TGU H645 P2 and embedded in it young open cluster NGC 7129 are
investigated using the results of medium-band photometry of 159 stars in the
Vilnius seven-colour system down to V = 18.8 mag. The photometric data were
used to classify about 50 percent of the measured stars in spectral and
luminosity classes. The extinction A_V vs. distance diagram for the 20x20
arcmin area is plotted for 155 stars with two-dimensional classification from
the present and the previous catalogues. The extinction values found range
between 0.6 and 3.4 mag. However, some red giants, located in the direction of
the dense parts of the cloud, exhibit the infrared extinction equivalent up to
A_V = 13 mag. The distance to the cloud (and the cluster) is found to be 1.15
kpc (the true distance modulus 10.30 mag). For determining the age of NGC 7129,
a luminosity vs. temperature diagram for six cluster members of spectral
classes B3 to A1 was compared with the Pisa pre-main-sequence evolution tracks
and the Palla birthlines. The cluster can be as old as about 3 Myr, but star
forming continues till now as witnessed by the presence in the cloud of many
younger pre-main-sequence objects identified with photometry from 2MASS,
Spitzer and WISE infrared surveys.Comment: 8 pages, 6 fugures, full Table 1 online. Accepted for publication in
MNRAS on 2013 November 3
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Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRα and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model
Purpose. Proliferative vitreoretinopathy (PVR) is a complication of retinal detachment characterized by redetachment of the retina as a result of membrane formation and contraction. A variety of retinal cells, including retinal pigment epithelial (RPE) and Müller glia, and growth factors may be responsible. Platelet-derived growth factor receptor alpha (PDGFRα) is found in large quantities in PVR membranes, and is intrinsic to the development of PVR in rabbit models. This study explores the expression of PDGFR in cocultures of RPE and Müller cells over time to examine how these two cell types may collaborate in the development of PVR. We also examine how changes in PDGFRα expression alter Müller cell pathogenicity. Methods. Human MIO-M1 Müller progenitor (MPC) and ARPE19 cells were studied in a transmembrane coculture system. Immunocytochemistry and Western blot were used to look at PDGFRα, PDGFRβ, and GFAP expression. A transfected MPC line cell line expressing the PDGFRα (MIO-M1α) was generated, and tested in a rabbit model for its ability to induce PVR. Results:. The expression of PDGFRα and PDGFRβ was upregulated in MIO-M1 MPCs cocultured with ARPE19 cells; GFAP was slightly decreased. Increased expression of PDGFRα in the MIO-M1 cell line resulted in increased pathogenicity and enhanced ability to induce PVR in a rabbit model. Conclusions:. Müller and RPE cell interaction can lead to upregulation of PDGFRα and increased Müller cell pathogenicity. Müller cells may play a more active role than previously thought in the development of PVR membranes, particularly when stimulated by an RPE-cell-rich environment. Additional studies of human samples and in animal models are warranted
Optical Bandgap Formation in AlInGaN Alloys
We report on the spectral dynamics of the reflectivity, site-selectively excited photoluminescence,photoluminescence excitation, and time-resolved luminescence in quaternary AlInGaN epitaxial layers grown on GaN templates. The incorporation of a few percents of In into AlGaN causes significant smoothening of the band-bottom potential profile in AlInGaN layers owing to improved crystal quality. An abrupt optical bandgap indicates that a nearly lattice-matched AlInGaN/GaN heterostructure with large energy band offsets can be grown for high-efficiency light-emitting devices
Blue and Deep‐Blue‐Emitting Organic Lasers with Top‐Layer Distributed Feedback Resonators
All‐solution processed surface‐emitting organic distributed feedback lasers are attractive devices for low‐cost applications. Here, lasers emitting in the spectral region between 375 and 475 nm, in which both active material and resonator (1D relief gratings) are based on solution‐processable polymer films, are reported. Ten different organic compounds dispersed in polystyrene are used as active layers of the prepared devices. They include various carbon‐bridged oligo(p‐phenylenevinylene) (COPVn, with n = 1,2) derivatives and two terfluorene compounds. The synthesis and complete optical and amplified spontaneous emission properties of one of the COPV1 compounds, COPV1(Me)‐t‐Bu, designed for deep‐blue emission, are also included. The feasibility of the resonator fabrication, performed by holographic lithography with a dichromated gelatine photoresist over the active film, is successfully demonstrated for all devices. Remarkably, no resolution limitations are found even for the lowest grating period (235 nm) required for the fabrication of the laser based on COPV1(Me)‐t‐Bu. It is also demonstrated that the rectangular grating profile with duty cycle 0.75:0.25 (hill:valley) is very convenient to optimize the resonator efficacy.The Spanish team acknowledges support from the Spanish Government (MINECO) and the European Community (FEDER) through Grant No. MAT2015-66586-R. H.T. and E.N. thank the financial support from MEXT (JP19H05716 for H.T. and JP19H0549 for E.N.)
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis
Diabetic retinopathy is the most common microvascular complication of diabetes,
characterized by the formation of fibrovascular membranes that consist of a variety of cells
including vascular endothelial cells (ECs). New therapeutic approaches for this diabetic
complication are urgently needed. Here, we report that in cultured human retinal
microvascular (HRECs) high glucose induced expression of p110, which was also
expressed in ECs of fibrovascular membranes from diabetic patients. This catalytic subunit
of a receptor regulated PI3K isoform is known to be highly-enriched in leukocytes. Using
genetic and pharmacological approaches, we show that p110 activity in cultured ECs
controls Akt activation, cell proliferation, migration, and tube formation induced by
vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth
factor. Using a mouse model of oxygen-induced retinopathy, p110 inactivation was found
to attenuate pathological retinal angiogenesis. p110 inhibitors have been approved for use
in human B-cell malignancies. Our data suggest that antagonizing p110 constitutes a
previously-unappreciated therapeutic opportunity for diabetic retinopathy
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