Measurements and Simulation Studies of Piezoceramics for Acoustic Particle Detection

Calibration sources are an indispensable tool for all detectors. In acoustic particle detection the goal of a calibration source is to mimic neutrino signatures as expected from hadronic cascades. A simple and promising method for the emulation of neutrino signals are piezo ceramics. We will present results of measruements and simulations on these piezo ceramics.Comment: 5 pages, 5 figure

Reconstruction methods for acoustic particle detection in the deep sea using clusters of hydrophones

This article focuses on techniques for acoustic noise reduction, signal filters and source reconstruction. For noise reduction, bandpass filters and cross correlations are found to be efficient and fast ways to improve the signal to noise ratio and identify a possible neutrino-induced acoustic signal. The reconstruction of the position of an acoustic point source in the sea is performed by using small-volume clusters of hydrophones (about 1 cubic meter) for direction reconstruction by a beamforming algorithm. The directional information from a number of such clusters allows for position reconstruction. The algorithms for data filtering, direction and position reconstruction are explained and demonstrated using simulated data.Comment: 7 pages, 13 figure

Development of High Granulated Straw Chambers of Large Sizes

We have developed the baseline design for the straw drift tube tracking detectors for high rate environment application. The low-mass inner straw elements and the technology of the multianode straws assembly was devised and checked. The prototype chamber was constructed and studied the granularity of similar chambers can be reduced to one cm2. Submitted to Physics of Elementary Particles and Atomic Nuclei, LettersComment: 6 pages, 10 figure

Contribution of the nucleon-hyperon reaction channels to K−^- production in proton-nucleus collisions

The cross sections for producing K$^-$ mesons in nucleon-hyperon elementary processes are estimated assuming one-pion exchange and using the experimentally known pion-hyperon cross sections. The results are implemented in a transport model which is applied to calculation of proton-nucleus collisions. In significant difference to earlier estimates for heavy-ion collisions the inclusion of the nucleon-hyperon cross section roughly doubles the K$^-$ production in near-threshold proton-nucleus collisions

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection

Abstract: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis induced by infection with Neisseria gonorrhoeae (Ngo). While Bim and Bmf were associated with the cytoskeleton of healthy cells, they both were released upon Ngo infection. Loss of Bim and Bmf from the cytoskeleton fraction required the activation of Jun-N-terminal kinase-1 (JNK-1), which in turn depended on Rac-1. Depletion and inhibition of Rac-1, JNK-1, Bim, or Bmf prevented the activation of Bak and Bax and the subsequent activation of caspases. Apoptosis could be reconstituted in Bim-depleted and Bmf-depleted cells by additional silencing of antiapoptotic Mcl-1 and Bcl-XL, respectively. Our data indicate a synergistic role for both cytoskeletal-associated BH3-only proteins, Bim, and Bmf, in an apoptotic pathway leading to the clearance of Ngo-infected cells. Author Summary: A variety of physiological death signals, as well as pathological insults, trigger apoptosis, a genetically programmed form of cell death. Pathogens often induce host cell apoptosis to establish a successful infection. Neisseria gonorrhoeae (Ngo), the etiological agent of the sexually transmitted disease gonorrhoea, is a highly adapted obligate human-specific pathogen and has been shown to induce apoptosis in infected cells. Here we unveil the molecular mechanisms leading to apoptosis of infected cells. We show that Ngo-mediated apoptosis requires a special subset of proapoptotic proteins from the group of BH3-only proteins. BH3-only proteins act as stress sensors to translate toxic environmental signals to the initiation of apoptosis. In a siRNA-based miniscreen, we found Bim and Bmf, BH3-only proteins associated with the cytoskeleton, necessary to induce host cell apoptosis upon infection. Bim and Bmf inactivated different inhibitors of apoptosis and thereby induced cell death in response to infection. Our data unveil a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic cell death

Integration of Acoustic Neutrino Detection Methods into ANTARES

The ANTARES Neutrino Telescope is a water Cherenkov detector currently under construction in the Mediterranean Sea. It is also designed to serve as a platform for investigations of the deep-sea environment. In this context, the ANTARES group at the University of Erlangen will integrate acoustic sensors within the infrastructure of the experiment. With this dedicated setup, tests of acoustic particle detection methods and deep-sea acoustic background studies shall be performed. The aim of this project is to evaluate the feasibility of a future acoustic neutrino telescope in the deep sea operating in the ultra-high energy regime. In these proceedings, the implementation of the project is described in the context of the premises and challenges set by the physics of acoustic particle detection and the integration into an existing infrastructure.Comment: 6 pages, 5 figures, to appear in the proceedings of the International ARENA Workshop, May 28-30th, 2006, University of Northumbri

Integration of Acoustic Detection Equipment into ANTARES

The ANTARES group at the University of Erlangen is working towards the integration of a set of acoustic sensors into the ANTARES Neutrino Telescope. With this setup, tests of acoustic particle detection methods and background studies shall be performed. The ANTARES Neutrino Telescope, which is currently being constructed in the Mediterranean Sea, will be equipped with the infrastructure to accommodate a 3-dimensional array of photomultipliers for the detection of Cherenkov light. Within this infrastructure, the required resources for acoustic sensors are available: Bandwidth for the transmission of the acoustic data to the shore, electrical power for the off-shore electronics and physical space to install the acoustic sensors and to route the connecting cables (transmitting signals and power) into the electronics containers. It will be explained how the integration will be performed with minimal modifications of the existing ANTARES design and which setup is foreseen for the acquisition of the acoustic data.Comment: 5 pages, 1 figure, to appear in the proceedings of the 1st International ARENA Workshop, May 17-19th, 2005, DESY Zeuthen (Germany

Testing Thermo-acoustic Sound Generation in Water with Proton and Laser Beams

Experiments were performed at a proton accelerator and an infrared laser acility to investigate the sound generation caused by the energy deposition of pulsed particle and laser beams in water. The beams with an energy range of 1 PeV to 400 PeV per proton beam spill and up to 10 EeV for the laser pulse were dumped into a water volume and the resulting acoustic signals were recorded with pressure sensitive sensors. Measurements were performed at varying pulse energies, sensor positions, beam diameters and temperatures. The data is well described by simulations based on the thermo-acoustic model. This implies that the primary mechanism for sound generation by the energy deposition of particles propagating in water is the local heating of the media giving rise to an expansion or contraction of the medium resulting in a pressure pulse with bipolar shape. A possible application of this effect would be the acoustical detection of neutrinos with energies greater than 1 EeV.Comment: 5 pages, 2 figures, to appear in the proceedings of the 1st International ARENA Workshop, May 17-19th, 2005, DESY Zeuthe

Development of Acoustic Sensors for the ANTARES Experiment

In order to study the possibility of acoustic detection of ultra-high energy neutrinos in water, our group is planning to deploy and operate an array of acoustic sensors using the ANTARES Neutrino telescope in the Mediterranean Sea. Therefore, acoustic sensor hardware has to be developed which is both capable of operation under the hostile conditions of the deep sea and at the same time provides the high sensitivity necessary to detect the weak pressure signals resulting from the neutrino's interaction in water. In this paper, two different approaches to building such sensors, as well as performance studies in the laboratory and in situ, are presented.Comment: 5 pages, 3 figures. Proceedings of the ARENA 2005 Worksho