1 research outputs found
Π Π΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ ΠΊ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ ΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠ°Π³Π°ΠΌ ΠΈΠ·ΠΎΠ»ΡΡΠΎΠ² Klebsiella pneumoniae, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ ΠΎΡ Π΄Π΅ΡΠ΅ΠΉ ΡΠ°Π·Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° Ρ ΠΊΠΈΡΠ΅ΡΠ½ΡΠΌΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡΠΌΠΈ
The aim is to study the antibiotic and phage resistance of K. pneumoniae strains isolated from children with acute intestinal infections. Materials and methods. 490 K. pneumoniae strains isolated by the bacteriological method from feces from patients with intestinal infections of various etiologies aged from 1 month to 18 years in the period 2019β2021 were studied. The diagnosis of intestinal infection caused by K. pneumoniae was established taking into account the detection of the pathogen at a concentration of at least 5 lg CFU/g (n = 283; 57.8%). Children with Klebsiella seeding, made up three age groups: from 1 to 12 months of life (n = 245; 50%); from 1 to 3 years (n = 131; 26.7%); from 3 to 18 years (n = 114; 23.3%). Results. A higher frequency of K. pneumoniae seeding in high concentrations from fecal samples of children with intestinal infections aged from 1 to 12 months was established (?2 = 14.24; p < 0.001). Analysis of the frequency of K. pneumoniae resistance to antimicrobials revealed its increase to ampicillin/sulbactam from 4.2 Β± 1.6% to 9.7 Β± 1.9% and to gentamicin from 3.0 Β± 1.3% to 7.6 Β± 1.7% (p < 0.05) with an increase in the concentration of the pathogen from 3β4 to 5β6 lg CFU/ml. In K. pneumoniae strains isolated in low concentrations, resistance to polyvalent anti-klebsiella bacteriophage was significantly higher than to monovalent bacteriophage. Conclusion. Children of the first year of life belong to the risk group for the development of klebsiella intestinal infection. An increase in the frequency of K. pneumoniae resistance to ampicillin/sulbactam and gentamicin correlates with an increase in the concentration of the pathogen in fecal samples.Π¦Π΅Π»Ρ β ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠΈΠΎΡΡΠΎΠΏΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΠΠ Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΡ
Π³ΡΡΠΏΠΏ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ ΡΡΠ°ΠΌΠΌΠΎΠ² Klebsiella Ρneumoniae Π²Π½Π΅Π±ΠΎΠ»ΡΠ½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΡΡ
ΠΎΠΆΠ΄Π΅Π½ΠΈΡ ΠΊ Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠ°ΠΌ ΠΈ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠ°Π³Π°ΠΌ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 490 ΡΡΠ°ΠΌΠΌΠΎΠ² K. pneumoniae, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠ· ΡΠ΅ΠΊΠ°Π»ΠΈΠΉ ΠΎΡ Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΊΠΈΡΠ΅ΡΠ½ΡΠΌΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡΠΌΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 1 ΠΌΠ΅ΡΡΡΠ° Π΄ΠΎ 18 Π»Π΅Ρ Π² ΠΏΠ΅ΡΠΈΠΎΠ΄ 2019β2021 Π³Π³. ΠΠΈΠ°Π³Π½ΠΎΠ· ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠΉ K. pneumoniae, ΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°Π»ΠΈ ΠΏΡΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΠΈ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Ρ Π² ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ 5 lg ΠΠΠ/Π³ (n = 283; 57,8%). ΠΠ΅ΡΠΈ Ρ Π²ΡΡΠ΅Π²ΠΎΠΌ ΠΊΠ»Π΅Π±ΡΠΈΠ΅Π»Π» ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ ΡΡΠΈ Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΠ΅ Π³ΡΡΠΏΠΏΡ: ΠΎΡ 1 Π΄ΠΎ 12 ΠΌΠ΅ΡΡΡΠ΅Π² (n = 245; 50%); ΠΎΡ 1 Π΄ΠΎ 3 Π»Π΅Ρ (n = 131; 26,7%); ΠΎΡ 3 Π΄ΠΎ 18 Π»Π΅Ρ (n = 114; 23,3%). Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠ°Ρ ΡΠ°ΡΡΠΎΡΠ° Π²ΡΡΠ΅Π²ΠΎΠ² K. pneumoniae Π² Π²ΡΡΠΎΠΊΠΈΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΡ
ΠΈΠ· ΡΠ΅ΠΊΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠΎΠ± Π΄Π΅ΡΠ΅ΠΉ Ρ ΠΊΠΈΡΠ΅ΡΠ½ΡΠΌΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡΠΌΠΈ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 1 Π΄ΠΎ 12 ΠΌΠ΅ΡΡΡΠ΅Π² (Ο2 = 14,24; p < 0,001). ΠΠ½Π°Π»ΠΈΠ· ΡΠ°ΡΡΠΎΡΡ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ K. pneumoniae ΠΊ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΡΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ Π²ΡΡΠ²ΠΈΠ» Π΅Π΅ Π½Π°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ ΠΊ Π°ΠΌΠΏΠΈΡΠΈΠ»Π»ΠΈΠ½Ρ/ΡΡΠ»ΡΠ±Π°ΠΊΡΠ°ΠΌΡ Ρ 4,2 Β± 1,6% Π΄ΠΎ 9,7 Β± 1,9% ΠΈ ΠΊ Π³Π΅Π½ΡΠ°ΠΌΠΈΡΠΈΠ½Ρ Ρ 3,0 Β± 1,3% Π΄ΠΎ 7,6 Β± 1,7% (p < 0,05) Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Ρ ΠΎΡ 3β4 Π΄ΠΎ 5β6 lg ΠΠΠ/ΠΌΠ». Π£ ΡΡΠ°ΠΌΠΌΠΎΠ² K. pneumoniae, Π²ΡΠ΄Π΅Π»Π΅Π½Π½ΡΡ
Π² Π½ΠΈΠ·ΠΊΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ, ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ ΠΊ ΠΏΠΎΠ»ΠΈΠ²Π°Π»Π΅Π½ΡΠ½ΠΎΠΌΡ Π°Π½ΡΠΈΠΊΠ»Π΅Π±ΡΠΈΠ΅Π»Π»Π΅Π·Π½ΠΎΠΌΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠ°Π³Ρ, Π±ΡΠ»Π° Π·Π½Π°ΡΠΈΠΌΠΎ Π²ΡΡΠ΅, ΡΠ΅ΠΌ ΠΊ ΠΌΠΎΠ½ΠΎΠ²Π°Π»Π΅Π½ΡΠ½ΠΎΠΌΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΡΠ°Π³Ρ. ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ΅ΡΠΈ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ Π³ΠΎΠ΄Π° ΠΆΠΈΠ·Π½ΠΈ ΠΎΡΠ½ΠΎΡΡΡΡΡ ΠΊ Π³ΡΡΠΏΠΏΠ΅ ΡΠΈΡΠΊΠ° ΠΏΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΊΠ»Π΅Π±ΡΠΈΠ΅Π»Π»Π΅Π·Π½ΠΎΠΉ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ. ΠΠ°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ ΡΠ°ΡΡΠΎΡΡ ΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΠΈ K. pneumoniae ΠΊ Π°ΠΌΠΏΠΈΡΠΈΠ»Π»ΠΈΠ½Ρ/ΡΡΠ»ΡΠ±Π°ΠΊΡΠ°ΠΌΡ ΠΈ ΠΊ Π³Π΅Π½ΡΠ°ΠΌΠΈΡΠΈΠ½Ρ ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΠ΅Ρ Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Ρ Π² ΠΏΡΠΎΠ±Π°Ρ
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