Standards and Infrastructure for Innovation Data Exchange

This is the author's accepted manuscript. The original publication is available at http://www.sciencemag.org/content/338/6104/196.Economic growth relies in part on efficient advancement and application of research and development (R&D) knowledge. This requires access to data about science, in particular R&D inputs and outputs such as grants, patents, publications, and data sets, to support an understanding of how R&D information is produced and what affects its availability. But there is a cacophony of R&D-related data across countries, disciplines, data providers, and sectors. Burdened with data that are inconsistently specified, researchers and policy-makers have few incentives or mechanisms to share or interlink cleaned data sets. Access to these data is limited by a patchwork of laws, regulations, and practices that are unevenly applied and interpreted (1). A Web-based infrastructure for data sharing and analysis could help. We describe administrative and technical demands and opportunities to meet them. Data exchange standards are a first step

Visible light photon counters optimization for quantum information applications

In this paper we describe the studies of the main parameters needed for optimal operation of Visible Light Photon Counters (VLPCs) when used in quantum information systems. The isolation of the single photon signal is analyzed through the definition of a contamination parameter. A compromise in the minimization of this parameter for temperature, bias voltage and dark count variation must be achieved and this depends on the experimental conditions

Cosmic ray tests of the D0 preshower detector

The D0 preshower detector consists of scintillator strips with embedded wavelength-shifting fibers, and a readout using Visible Light Photon Counters. The response to minimum ionizing particles has been tested with cosmic ray muons. We report results on the gain calibration and light-yield distributions. The spatial resolution is investigated taking into account the light sharing between strips, the effects of multiple scattering and various systematic uncertainties. The detection efficiency and noise contamination are also investigated.Comment: 27 pages, 24 figures, submitted to NIM

kt Effects in Direct-Photon Production

We discuss the phenomenology of initial-state parton-kt broadening in direct-photon production and related processes in hadron collisions. After a brief summary of the theoretical basis for a Gaussian-smearing approach, we present a systematic study of recent results on fixed-target and collider direct-photon production, using complementary data on diphoton and pion production to provide empirical guidance on the required amount of kt broadening. This approach provides a consistent description of the observed pattern of deviation of next-to-leading order QCD calculations relative to the direct-photon data, and accounts for the shape and normalization difference between fixed-order perturbative calculations and the data. We also discuss the uncertainties in this phenomenological approach, the implications of these results on the extraction of the gluon distribution of the nucleon, and the comparison of our findings to recent related work.Comment: LaTeX, uses revtex and epsf, 37 pages, 15 figure

Measurement of direct photon production at Tevatron fixed target energies

Measurements of the production of high transverse momentum direct photons by a 515 GeV/c piminus beam and 530 and 800 GeV/c proton beams in interactions with beryllium and hydrogen targets are presented. The data span the kinematic ranges of 3.5 < p_T < 12 GeV/c in transverse momentum and 1.5 units in rapidity. The inclusive direct-photon cross sections are compared with next-to-leading-order perturbative QCD calculations and expectations based on a phenomenological parton-k_T model.Comment: RevTeX4, 23 pages, 32 figures, submitted to Phys. Rev.

mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation

We have shown that inhibition of mTOR in granulosa cells and ovarian follicles results in compromised granulosa proliferation and reduced follicle growth. Further analysis here using spontaneously immortalized rat granulosa cells has revealed that mTOR pathway activity is enhanced during M-phase of the cell cycle. mTOR specific phosphorylation of p70S6 kinase and 4E-BP, and expression of Raptor are all enhanced during M-phase. The predominant effect of mTOR inhibition by the specific inhibitor Rapamycin (RAP) was a dose-responsive arrest in the G1 cell cycle stage. The fraction of granulosa cells that continued to divide in the presence of RAP exhibited a dose-dependent increase in aberrant mitotic figures known as anaphase bridges. Strikingly, estradiol consistently decreased the incidence of aberrant mitotic figures. In mice treated with RAP, the mitotic index was reduced compared to controls, and a similar increase in aberrant mitotic events was noted. RAP injected during a superovulation regime resulted in a dose-dependent reduction in the numbers of eggs ovulated. Implications for the real-time regulation of follicle growth and dominance, including the consequences of increased numbers of aneuploid granulosa cells, are discussed

Production of pizero and eta mesons at large transverse momenta in pi-p and pi-Be interactions at 515 GeV/c

We present results on the production of high transverse momentum pizero and eta mesons in pi-p and pi-Be interactions at 515 GeV/c. The data span the kinematic ranges 1 < p_T < 11 GeV/c in transverse momentum and -0.75 < y < 0.75 in rapidity. The inclusive pizero cross sections are compared with next-to-leading order QCD calculations and to expectations based on a phenomenological parton-k_T model.Comment: RevTeX4, 15 pages, 15 figures, to be submitted to Phys. Rev.

Mitochondrial echoes of first settlement and genetic continuity in El Salvador

Background: From Paleo-Indian times to recent historical episodes, the Mesoamerican isthmus played an important role in the distribution and patterns of variability all around the double American continent. However, the amount of genetic information currently available on Central American continental populations is very scarce. In order to shed light on the role of Mesoamerica in the peopling of the New World, the present study focuses on the analysis of the mtDNA variation in a population sample from El Salvador. Methodology/Principal Findings: We have carried out DNA sequencing of the entire control region of the mitochondrial DNA (mtDNA) genome in 90 individuals from El Salvador. We have also compiled more than 3,985 control region profiles from the public domain and the literature in order to carry out inter-population comparisons. The results reveal a predominant Native American component in this region: by far, the most prevalent mtDNA haplogroup in this country (at ~90%) is A2, in contrast with other North, Meso- and South American populations. Haplogroup A2 shows a star-like phylogeny and is very diverse with a substantial proportion of mtDNAs (45%; sequence range 16090–16365) still unobserved in other American populations. Two different Bayesian approaches used to estimate admixture proportions in El Salvador shows that the majority of the mtDNAs observed come from North America. A preliminary founder analysis indicates that the settlement of El Salvador occurred about 13,400±5,200 Y.B.P.. The founder age of A2 in El Salvador is close to the overall age of A2 in America, which suggests that the colonization of this region occurred within a few thousand years of the initial expansion into the Americas. Conclusions/Significance: As a whole, the results are compatible with the hypothesis that today's A2 variability in El Salvador represents to a large extent the indigenous component of the region. Concordant with this hypothesis is also the observation of a very limited contribution from European and African women (~5%). This implies that the Atlantic slave trade had a very small demographic impact in El Salvador in contrast to its transformation of the gene pool in neighbouring populations from the Caribbean facade

Examination of direct-photon and pion production in proton-nucleon collisions

We present a study of inclusive direct-photon and pion production in hadronic interactions, focusing on a comparison of the ratio of gamma/pi0 yields with expectations from next-to-leading order perturbative QCD (NLO pQCD). We also examine the impact of a phenomenological model involving k_T smearing (which approximates effects of additional soft-gluon emission) on absolute predictions for photon and pion production and their ratio.Comment: 20 pages, 12 figures. Minor changes in wording and in figure