The application of legal-statistical method in analysing manufacturing property’s institutional development

Purpose: The study defines the specifics and opportunities, that arise due to the application of statistical method in judicial research of manufacturing property. Design/Methodology/Approach: The authors put the ground of the study on the aggregation of a vast spectrum of statistical data and indicators of patent activity of leading countries in the sphere of technological innovation. Findings: The authors outlined the main tendencies of legal regulation of scientific and artistic results of intellectual property development and define the specifics and opportunities that arise due to the application of statistical method in judicial research of manufacturing property. Lack of coordination of approaches to protect manufacturing property on the international level, obstructs the development of patent activity amongst the members of the Paris Convention and significantly reduces the effectiveness of the current patent system. Practical implications: Authors' development could be utilized in future developments of Russian institute of manufacturing property and its legal framework. Originality/Value: The contribution of the article is the comprehensive analysis of legal background of intellectual property institute and its development prospects.peer-reviewe

DIAGNOSIS OF GROUPS OF ELECTRO-RADIO COMPONENTS ACCORDING TO THE TRANSIENT RESPONSES FOR THE DETECTION OF DEFECTS ON THE FUNCTIONAL CELLS

Objectives. A method for diagnosing electronic components with minimally complicated control and measuring instrumentation and the ability to obtain information from internal control points of operating units is developed. Methods. The developed method for control of groups of electronic components presupposes the passage of a controllable influence through a few control points, connected via several electronic components. In addition, each electronic component contributes its share to the transformation of the parameter output, so the discrepancy of its allowable values for the identification of defective electronic component are required to assess the implication of the expected value of the probable defect of each electronic component in the schema with the aim of isolating it. The faulty component in the electronic circuit is identified by the minimum estimated variance, by which the magnitude of the defect will match the expected value of the electronic component parameter. Results. As a result of the control no more than ten groups of electrical components on functional cell matrices can be assessed as having a defective element by comparing the calculated variance values for each electrical component and the corresponding electrical component parameter itself. Conclusion. Diagnosing groups of electric components on transient characteristics for the detection of defects in the functional cell matrices enables efficiency control operations improvement and troubleshooting in the search for modern electronic equipment reliability

The microbial load and the severity of morphological changes in the prostate during infection with various titers of uropathogens: a comparison of data from an animal model study

Introduction. It has been established in an animal model that coagulase-negative staphylococci (Staphylococcus haemolyticus) and anaerobes (Peptococcus niger) cause the development of an acute inflammatory process in the prostate when inoculated with 103 CFU/ml. At the same time, data have been published indicating the pathogenic potential of these microorganisms on a titer of 102 CFU/ml. But it was confirmed for the model of acute obstructive pyelonephritis. In addition, the characteristics of the formation of the inflammatory response at different times were determined, which require detailed verification and comparative characteristics with those during infection with a causative uropathogen (Escherichia coli).Objective. Based on the results of the experiment, to carry out: 1) an evaluation of the relationship between the dynamics of microbial load and the degree of pathomorphological changes in prostate tissues during infection with various uropathogens in a titer of 103 CFU/ml; 2) an evaluation of the degree of microbial load and severity of histological changes in prostate tissues on follow-up day 7 with transurethral infection with various uropathogens in a subpathogenic titer of 102 CFU/ml; 3) a fundamental comparative analysis of the indicators of contamination and the severity of inflammatory changes on follow-up day 7 after the inoculation of various uropathogens in titers of 102 and 103 CFU/ml.Materials and methods. The animal model was performed using the FELASA and ARRIVE guidelines. Lab animals: 20 New Zealand rabbits. Uropathogens: E. coli, S. haemolyticus, and P. niger. Infectious titers: 102.3 cfu/ml. Uropathogen inoculation technique: topical transurethral. Randomization: all laboratory animals were divided into 4 groups depending on the uropathogen (3 experimental, 1 control). Follow-up periods: day 1, 3, 7 and 14 for a titer of 103 CFU/ml, and day 7 for a titer of 102 CFU/ml. At the end of the follow-up, euthanasia and autopsy were performed with the extraction of the urogenital organ complex. Hereafter, biopsies were taken from various parts of the prostate. Cultural and histological studies of prostate tissues were carried out using standard methods. The results were analyzed using Statistica 10.2 (StatSoft Inc., Tulsa, OK, USA) and GraphPad Prism 9 (GraphPad Software Inc., Graphpad Holdings LLC, San Diego, CA, USA) programs through descriptive and nonparametric statistics.Results. Bacterial contamination of prostate tissue was determined in all cases of infection with differences (p < 0.05) in some indicators between the E. coli and P. niger groups at different observation periods, but only in the case of inoculation of the test titer of 103 CFU/ml. Histological evaluation of prostate tissues after inoculation with 103 CFU/ml verified the presence of acute destructive changes in the prostate from the follow-up day 1, which were more pronounced in the S. haemolyticus and E. coli groups. However, similar characteristics of the development of the inflammatory process in the form of hyper-eosinophilic infiltration in the early stages and pronounced congestion of the prostatic glands were identified in the S. haemolyticus and P. niger groups. Comparison of trends in dynamic changes of microbial load (rise / decline) and severity of pathological changes (increase / resolution) in prostate tissues in established follow-up periods showed the presence of relative synchronization of trends (from days 1 to 7) in the S. haemolyticus and P. niger groups, and complete synchronization in the E. coli group. When comparing the median microbial load of the prostate on the follow-up day 7, no intergroup (p > 0.05) differences were found both in cases of infection with a titer of 103 CFU/ml, and when compared with the data on contamination for a test titer of 102 CFU/ml, at the same time observations. At once, when E. coli and S. haemolyticus were infected at a subpathogenic titer of 102 CFU/ml, inflammatory changes were recorded that had a mild diffuse character, in relation to those after inoculation of these pathogens in a titer of 103 CFU/ml. In turn, P. niger induced the development of low-intensity focal alteration in isolated areas of prostate tissues.Conclusions. Detailed analysis of culture and histological data showed that E. coli, S. haemolyticus and P. niger have significant pathogenic potential at titer of 103 CFU/ml. In turn, when the titer decreases to 102 CFU/ml, E. coli and S. haemolyticus retain their pathogenic potential, but the severity of the inflammatory reaction is significantly reduced. It was also found that a change in bacterial contamination affects the severity of the inflammatory process in all groups during seven follow-up days at a given test titer

On a factorization of second order elliptic operators and applications

We show that given a nonvanishing particular solution of the equation (divpgrad+q)u=0 (1) the corresponding differential operator can be factorized into a product of two first order operators. The factorization allows us to reduce the equation (1) to a first order equation which in a two-dimensional case is the Vekua equation of a special form. Under quite general conditions on the coefficients p and q we obtain an algorithm which allows us to construct in explicit form the positive formal powers (solutions of the Vekua equation generalizing the usual powers of the variable z). This result means that under quite general conditions one can construct an infinite system of exact solutions of (1) explicitly, and moreover, at least when p and q are real valued this system will be complete in ker(divpgrad+q) in the sense that any solution of (1) in a simply connected domain can be represented as an infinite series of obtained exact solutions which converges uniformly on any compact subset of . Finally we give a similar factorization of the operator (divpgrad+q) in a multidimensional case and obtain a natural generalization of the Vekua equation which is related to second order operators in a similar way as its two-dimensional prototype does

PHASES High Precision Differential Astrometry of delta Equulei

delta Equulei is among the most well-studied nearby binary star systems. Results of its observation have been applied to a wide range of fundamental studies of binary systems and stellar astrophysics. It is widely used to calibrate and constrain theoretical models of the physics of stars. We report 27 high precision differential astrometry measurements of delta Equulei from the Palomar High-precision Astrometric Search for Exoplanet Systems (PHASES). The median size of the minor axes of the uncertainty ellipses for these measurements is 26 micro-arcseconds. These data are combined with previously published radial velocity data and other previously published differential astrometry measurements using other techniques to produce a combined model for the system orbit. The distance to the system is determined to within a twentieth of a parsec and the component masses are determined at the level of a percent. The constraints on masses and distance are limited by the precisions of the radial velocity data; we outline plans improve this deficiency and discuss the outlook for further study of this binary.Comment: Accepted by AJ. Complete versions of tables 2-7 now available at http://stuff.mit.edu/~matthew1/deltaEquTables/ (removed from astroph server

Гидрофобизация и упрочнение целлюлозных материалов из вторичных ресурсов

The influence of the sizing agent and filler on the physical-mechanical and surface properties of paper from the cellulose mass of the inner layer of the bark of mulberry tree branches has been studied. According to standard methods, the mechanical strength and absorbency were studied. Surface absorbency for one-side wetting was determined by the method of Cobb(30), by determining the mass of water absorbed by the paper surface when wetting one side of the test sample. It was found that it is advisable to add a sizing agent in the range from 1 to 1.5 g per 100 g of dry cellulose raw materials, since an increase in the additive to 2 g helps to reduce the interfiber bonding forces by 21 %. The addition of 6 g of kaolin affects the distance between the fibers, which reduces the mechanical adhesive forces by 12.5 %. During the analysis of the surface properties of paper samples, the sizing efficiency was found to be from 22.5 to 30 % with an increase in the addition of sizing glue, which can be explained by densification of the structure, which prevents the penetration of aqueous solutions. The addition of 2 to 6 g of kaolin also increases water resistance from 17.5 to 25 %. With the help of a mathematical model, rational values of absorbency were revealed with a composition of 92 %, with a sizing agent of 1.5 g and an amount of filler of 4 g. The resulting mathematical model can be used as the basis for controlling the surface characteristics of paper during its production.Исследовано влияние проклеивающего вещества и наполнителя на физико-механические и поверхностные свойства бумаги из целлюлозной массы внутреннего слоя коры веток тутового дерева. По стандартным методикам изучены механическая прочность и впитывающая способность. Поверхностную впитываемость при одностороннем смачивании определяли по методу Кобб(30), путем определения массы воды, поглощенной поверхностью бумаги при смачивании одной стороны испытуемого образца. Выявлено, что целесообразно добавление проклеивающего вещества в пределах от 1 до 1,5 г на 100 г сухого целлюлозного сырья, так как увеличение добавки до 2 г способствует уменьшению межволоконных сил связи на 21 %. Добавление каолина в количестве 6 г влияет на расстояние между волокнами, что уменьшает механические силы сцепления на 12,5 %. В ходе анализа поверхностных свойств образцов бумаги определена эффективность проклейки от 22,5 до 30 % с увеличением проклеивающего вещества, что можно объяснить уплотнением структуры, которая препятствует проникновению водных растворов. Добавление каолина от 2 до 6 г также повышает стойкость к воде от 17,5 до 25 %. С помощью математической модели показаны рациональные значения впитывающей способности при составе бумажной массы 92 % при проклеивающем веществе 1,5 г и количестве наполнителя 4 г. Полученная математическая модель может быть положена в основу управления поверхностных характеристик бумаги в процессе ее производства

Поверхностные и оптические свойства бумаги, содержащей карбонат кальция

The article investigates the surface and optical properties of calcium carbonate paper obtained at the UzbekChinese enterprise Fergana stone paper company (Uzbekistan), in order to identify the possibility of their use at printing enterprises for printing multicolor products using traditional printing methods. According to the results of a quantitative assessment of the surface quality by the indirect Beck method, we can say that paper sample 1 has a smoothness like coated paper (750–1500 s), paper samples 2 and 3 – like calendered paper, so that these paper samples can be recommended for prints with increased quality requirements. Smaller values of roughness Ra and small depressions, expressed by darkening in the topographic AFM images, characterized sufficient homogeneity and density of the structure. It was also revealed that the surface of the paper samples has a high ability to specularly reflect the incident light, since the percentage of surface reflection is similar to that of coated papers. Samples of paper have a whiteness of about 90 % and do not have a tint, since the difference between the maximum and minimum values of the reflection coefficients on a white stack is not more than 10 %. The tested paper samples can be recommended without restrictions for double-sided printing, since the opacity index is more than 92 %.Исследованы поверхностные и оптические свойства бумаги из карбоната кальция, полученной в условиях Узбекско-китайского предприятия Fergana stone paper company (Узбекистан), с целью выявления возможности ее использования на полиграфических предприятиях для печати многокрасочной продукции с применением традиционных способов печати. По результатам количественной оценки качества поверхности косвенным методом Бека можно утверждать, что образец бумаги № 1 обладает гладкостью, как у мелованной бумаги (750–1500 с), образцы бумаги № 2 и 3, как у бумаг каландрированных, которые можно рекомендовать для изданий с повышенными требованиями к качеству. Меньшие значения шероховатости Ra и небольшие углубления, выраженные затемнением на топографических АСМ-изображениях, характеризовали достаточную однородность и плотность структуры. Также выявлено, что поверхность образцов бумаги обладает высокой способностью зеркально отражать падающий свет, так как процент отражения поверхностей такой же, как у мелованных бумаг. Образцы бумаги имеют белизну порядка 90 % и нет оттенка, так как разница между максимальным и минимальным значениями коэффициентов отражения на белой стопе не больше 10 %. Исследуемые образцы бумаги можно без ограничений рекомендовать для двусторонней печати, так как показатель светонепроницаемости больше 92 %

Multi-stage urethroplasy for anterior urethral strictures: objective parameters of long-term efficacy and patient-reported outcomes

Introduction. Multi-stage urethral surgery is used in cases of the most complex urethral strictures. The evaluation of surgical treatment results given by patients is a significant criterion for the efficacy of urethroplasty along with the assessment of urethral patency through instrumental examinations.Objective. To evaluate the long-term efficacy of multistage urethroplasty for complex anterior urethral strictures considering the patients' quality of life and satisfaction with the surgical outcomes.Materials and methods. The study included 73 patients aged 18 – 84 years with anterior urethral strictures who underwent multi-stage urethroplasty in 2010 – 2019. Surgical and functional outcomes of urethroplasty were assessed through general blood and urine tests, physical examination, uroflowmetry, and retrograde urethrography and urethroscopy in case of urinary disorders.  Subjective parameters of treatment efficacy were studied using questionnaires: International Prostate Symptom Score (IPSS); Quality of life (QoL); Patient-reported Outcome Measure for Urethral Stricture Surgery (USS-PROM); Patient Global Impression of Improvement (PGI-I).Results. Recurrent urethral stricture was detected in 19 (26,0%) patients with the average follow-up period being 65 months. Independent urination was restored in 71 (97.3%) cases, including repeated interventions. After surgery, there was a significant increase in urinary flow rate parameters (Q max: 8.1 vs 19.1 ml/s, p < 0.0001; Q ave: 5.5 vs 10.7 ml/s; p = 0.0004), decrease in residual urine volume (62.4 vs 18.6 ml, p < 0.0001), decrease in total IPSS score (18.7 vs 5.7 points; p < 0.0001) and QoL index (4.3 vs 1 .8 points, p < 0.0001). A comparative analysis of preoperative and postoperative USS-PROM questionnaire results demonstrated an improvement in indicators assessing LUTS (12.9 vs 3.4 points; p < 0.0001; 3.6 vs 1.7 points; p < 0.0001), and urination-associated quality of life (2.6 vs 0.6 points; p < 0.0001) and overall health (EQ-5D index: 0.73 vs 0.91 points; p = 0.025; EQ-VAS: 68.0 vs 88.1 points, p = 0.004). Fifty-seven (81.4%) men were “very satisfied” or “satisfied” with the treatment outcomes, while nine (12.9%) respondents noted a moderate effect of residual urinary disorders on the quality of life. Significantly higher satisfaction was observed among cystostomy patients and in cases where repeated interventions were unnecessary.Conclusion. Multi-stage urethroplasty for complex anterior urethral strictures achieves efficacy in 97.3% of cases and is accompanied by high levels of quality of life and patient’s satisfaction during long-term follow-up

PHASES Differential Astrometry and Iodine Cell Radial Velocities of the kappa Pegasi Triple Star System

kappa Pegasi is a well-known, nearby triple star system. It consists of a ``wide'' pair with semi-major axis 235 milli-arcseconds, one component of which is a single-line spectroscopic binary (semi-major axis 2.5 milli-arcseconds). Using high-precision differential astrometry and radial velocity observations, the masses for all three components are determined and the relative inclinations between the wide and narrow pairs' orbits is found to be 43.8 +/- 3.0 degrees, just over the threshold for the three body Kozai resonance. The system distance is determined to 34.60 +/- 0.21 parsec, and is consistent with trigonometric parallax measurements.Comment: Accepted for publication in ApJ, complete versions of tables 2 and 4 can be found at http://stuff.mit.edu/~matthew1/kapPegTables

The Disk Wind in the Young Binaries and the Origin of the Cyclic Activity of Young Stars

We present results of numerical modeling of the cyclic brightness modulation in the young binary systems with the eccentric orbits and low-mass secondary components. Brightness variations of the primary is due to the periodical extinction variations on the line-of-sight caused by the disk wind of the secondary and a common envelope it produces. A matter distribution in the envelope has been calculated in the ballistic approach. Calculations showed that for the young binaries with the elliptic orbits parameters of the photometric minima (their depth, duration and the shape of light curves) depend not only on the disk wind parameters and an inclination of the binary orbit to the line-of-sight but also on the longitude of the periastron. A modulation of the scattered radiation of the common envelope with a phase of the orbital period has been investigated in the single scattering approach. It is shown that an amplitude of the modulation is maximal when the system is seen edge-on and has also a non-zero value in the binaries observed pole-on. Possible applications of the theory to the young stellar objects are discussed. In particular, an attention is payed to a resemblance of the light curves in some models with light curves of the objects suspected as candidates to FUORs.Comment: 18 pages, 9 figures, accepted by Astronomy Letter