Antibacterial and antibiofilm activity of polyfunctional benzimidazole derivatives

Introduction. Compounds based on fused imidazole derivatives can become the basis for the development of a new generation of clinical therapeutic agents for more effective treatment of resistant human bacterial infections. This requires research, including the design, synthesis, and screening of biologically active compounds of this group.The aim. To study the effect of polyfunctional benzimidazole derivatives on the survival of Escherichia coli AB1157 culture and its ability to form biofilms.Methods. The antibacterial activity of the studied compounds was evaluated using the serial dilution method. Modeling of the formation of biofilms was carried out in the wells of an immunological plate with subsequent staining of the biomass with crystal violet.Results. The inhibitory activity of some of the studied compounds on the formation of biofilms by the Gram-negative bacterium E. coli AB1157 was demonstrated. The most pronounced inhibitory effect on E. coli AB1157 biofilms was exerted by 5-bromo-2-(trifluoromethyl)-1-H-benzimidazole. The level of biofilm formation decreased by 2–4 times in the area of concentrations of 15–60 µg/ml and by 8–10 times at concentrations of 125 µg/ml and above.Conclusion. The presented work expands the knowledge about the biological activity of benzimidazoles. The obtained results show that benzimidazole derivatives are good candidates for the development of new drugs against biofilms. The data obtained are of practical interest and need further study

Energi-Saving Technologies in the Construction of a House

The object of the study is a house under construction, which is located in Krasnoturinsk at the address Bazhova street, house 2. The purpose of the project: to study and explore ways to improve the energy efficiency of a residential house during its construction. Subject of research: comparative analysis of materials and structures used in construction. The hypothesis of the project - the introduction of energy-saving technologies in the construction of residential houses increases its energy efficiency and entails economic benefits. The construction of the house was accompanied by an energy survey using a thermal imager. One of the most effective energy-saving measures is the choice of high-quality and safe thermal insulation.Объектом исследования является жилой дом в период строительства, который расположен в г. Краснотурьинске по адресу ул. Бажова, дом 2. Цель проекта: изучить и исследовать способы повышения энергоэффективности жилого дома при его строительстве. Предмет исследования: сравнительный анализ применяемых материалов и конструкций при строительстве. Гипотеза проекта - внедрение энергосберегающих технологий при строительстве жилого дома повышает его энергоэффективность и влечет за собой экономическую выгоду. Строительство дома сопровождалось проведением энергетического обследования с помощью тепловизора. Одним из наиболее эффективных энергосберегающих мероприятий является выбор качественной и безопасной тепловой изоляции

Modern Trends of Organic Chemistry in Russian Universities

© 2018, Pleiades Publishing, Ltd. This review is devoted to the scientific achievements of the departments of organic chemistry in higher schools of Russia within the past decade