Observational Evidence for Massive Black Holes in the Centers of Active Galaxies

Naturally occurring water vapor maser emission at 1.35 cm wavelength provides an accurate probe for the study of accretion disks around highly compact objects, thought to be black holes, in the centers of active galaxies. Because of the exceptionally fine angular resolution, 200 microarcseconds, obtainable with very long baseline interferometry, accompanied by high spectral resolution, < 0.1 km/s, the dynamics and structures of these disks can be probed with exceptional clarity. The data on the galaxy NGC4258 are discussed here in detail. The mass of the black hole binding the accretion disk is 3.9 times 10^7 solar masses. Although the accretion disk has a rotational period of about 800 years, the physical motions of the masers have been directly measured with VLBI over a period of a few years. These measurements also allow the distance from the earth to the black hole to be estimated to an accuracy of 4 percent. The status of the search for other maser/black hole candidates is also discussed.Comment: 24 pages, 11 figures, latex, uses aaspp4 style file. To be published in the Journal of Astronomy and Astrophysics (India), proceedings of the Discussion Meeting on the Physics of Black Holes, Bangalore, India: December 199

Reduced mitochondrial respiration in T cells of patients with major depressive disorder

Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology