Manual / Issue 6 / Assemblage

Manual, a journal about art and its making. Assemblage. The sixth issue. An assemblage is both an act and a result-the work of gathering and conjoining as well as the state of having been gathered and conjoined. This issue of Manual pieces together works made out of practical necessity and others that marry dazzling embellishments for optimal effect, examining how history (or one version of it) was (and is) pastiched from disparate sources, how fashionable textile samples were collected, and more (always more). An assembly of assemblages, an assortment of intended and unintended interrelationships, Manual issue six is the sum of its parts and the parts themselves, a dynamic gathering of artists and authors, objects and interpretations, mash-ups and remixes, lemons and lightbulbs, vibrantly inter-animating each other. Softcover, 68 pages. Published 2016 by the RISD Museum. Manual 6 (Assemblage) contributors include Eric Anderson, Taylor Elyse Anderson, Bob Dilworth, Christina Hemauer, Roman Keller, Mariani Lefas-Tetenes, Simone Leigh, Leora Maltz-Leca, Ingrid A. Neuman, Tara Nummedal, Todd Oldham, and Britany Salsbury.https://digitalcommons.risd.edu/risdmuseum_journals/1032/thumbnail.jp

Enhanced Brain Disposition and Effects of Δ9-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice

The ABC transporters P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) regulate the CNS disposition of many drugs. The main psychoactive constituent of cannabis Δ9-tetrahydrocannabinol (THC) has affinity for P-gp and Bcrp, however it is unknown whether these transporters modulate the brain accumulation of THC and its functional effects on the CNS. Here we aim to show that mice devoid of Abcb1 and Abcg2 retain higher brain THC levels and are more sensitive to cannabinoid-induced hypothermia than wild-type (WT) mice. Abcb1a/b (−/−), Abcg2 (−/−) and wild-type (WT) mice were injected with THC before brain and blood were collected and THC concentrations determined. Another cohort of mice was examined for THC-induced hypothermia by measuring rectal body temperature. Brain THC concentrations were higher in both Abcb1a/b (−/−) and Abcg2 (−/−) mice than WT mice. ABC transporter knockout mice exhibited delayed elimination of THC from the brain with the effect being more prominent in Abcg2 (−/−) mice. ABC transporter knockout mice were more sensitive to THC-induced hypothermia compared to WT mice. These results show P-gp and Bcrp prolong the brain disposition and hypothermic effects of THC and offer a novel mechanism for both genetic vulnerability to the psychoactive effects of cannabis and drug interactions between CNS therapies and cannabis

Surface Chemistry of the Molecular Solar Thermal Energy Storage System 2,3 Dicyano Norbornadiene Quadricyclane on Ni 111

Molecular solar thermal MOST systems are a promising approach for the introduction of sustainable energy storage solutions. We investigated the feasibility of the dicyano substituted norbornadiene quadricyclane molecule pair on Ni 111 for catalytic model studies. This derivatization is known to lead to a desired bathochromic shift of the absorption maximum of the parent compound. In our experiments further favorable properties were found At low temperatures, both molecules adsorb intact without any dissociation. In situ temperature programmed HR XPS experiments reveal the conversion of CN 2 quadricyclane to CN 2 norbornadiene under energy release between 175 and 260 amp; 8197;K. The absence of other surface species due to side reactions indicates full isomerization. Further heating leads to the decomposition of the molecular framework into smaller carbonaceous fragments above 290 amp; 8197;K and finally to amorphous structures, carbide and nitride above 400 amp; 8197;K. DFT calculations gave insights into the adsorption geometries. CN 2 norbornadiene is expected to interact stronger with the surface, with flat configurations being favorable. CN 2 quadricyclane exhibits smaller adsorption energies with negligible differences for flat and side on geometries. Simulated XP spectra are in good agreement with experimental findings further supporting the specific spectroscopic fingerprints for both valence isomer