29,654 research outputs found

    Cultivating Perception: Phenomenological Encounters with Artworks

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    Phenomenally strong artworks have the potential to anchor us in reality and to cultivate our perception. For the most part, we barely notice the world around us, as we are too often elsewhere, texting, coordinating schedules, planning ahead, navigating what needs to be done. This is the level of our age that shapes the ways we encounter things and others. In such a world it is no wonder we no longer trust our senses. But as feminists have long argued, thinking grounded in embodied experience can be more open to difference; such embodied thinking helps us to resist the colonization of a singular, only seemingly neutral, perspective that closes down living potentialities

    This body of art: The singular plural of the feminine

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    I explore the possibility that the feminine, like art, can be thought in terms of Jean-Luc Nancy’s concept of the singular plural. In Les Muses, Nancy claims that art provides for the rethinking of a technĂ« not ruled by instrumentality. Specifically, in rethinking aesthetics in terms of the debates laid out by Kant, Hegel and Heidegger, he resituates the ontological in terms of the specificity of the techniques of each particular artwork; each artwork establishes relations particular to its world or worlds. What is at stake in the singular plural is the multiplicity of relations that are lost in the unifying gestures that arise out of radical oppositions. I rethink the singular plural through a phenomenological encounter with Barb Hunt’s artwork, Antipersonnel, a collection of hand-knitted replicas of antipersonnel landmines

    Electron Detachment Dissociation,and Collision-Induced Dissociation of Polyamidoamine (PAMAM) Dendrimer Ions with Amino, Amidoethanol, and Sodium Carboxylate Surface Groups

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    Here, we investigate the effect of the structure (generation) and nature of the surface groups of different polyamidoamine (PAMAM) dendrimers on electron-mediated dissociation, either electron capture dissociation (ECD) or electron detachment dissociation (EDD), and compare the fragmentation with that observed in collision-induced dissociation (CID). ECD and EDD of the PAMAM dendrimers esulted in simple mass spectra, which are straightforward to interpret, whereas CID produced complex mass spectra. The results show that electron-mediated dissociation (ECD and EDD) of PAMAM dendrimers does not depend on the nature of the surface group but tends to occur within the innermost generations. CID of the PAMAM dendrimers showed a strong dependence on the nature of the surface group and occurred mostly in the outer generation. The results demonstrate the potential utility of ECD and EDD as a tool for the structural analysis of PAMAM dendrimers

    Molecular lesions associated with white gene mutations induced by I-R hybrid dysgenesis in Drosophila melanogaster

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    We have identified molecular lesions associated with six mutations, w(IR2) and w(IR4-8), of the white gene of Drosophila melanogaster. These mutations arose in flies subject to I-R hybrid dysgenesis. Four of the mutations give rise to coloured eyes and are associated with insertions of 5.4-kb elements indistinguishable from the I factor controlling I-R dysgenesis. The insertion associated with w(IR4) is at a site which, within the resolution of these experiments, is identical to that of two previously studied I factors. This appears to be a hot-spot for I factor insertion. We have compared the sites of these insertions with sequences complementary to white gene mRNA identified by Pirrotta and Bröckl. The hot-spot is in the fourth intron. The insertion carried by w(IR5) is either within, or just beyond, the last exon. The insertion carried by w(IR6) is near the junction of the first exon and first intron. The w(IR2) mutation is a derivative of w(1). It contains an insertion of I factor DNA within, or immediately adjacent to, the F-like element associated with w(1), and results in restoration of some eye colour. This insertion is just upstream of the start of the white mRNA. Mutations w(IR7) and w(IR8) are deletions removing mRNA coding sequences. Both determine a bleached white phenotype

    Modeling the Rise in Internet-based Petitions

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    Contemporary collective action, much of which involves social media and other Internet-based platforms, leaves a digital imprint which may be harvested to better understand the dynamics of mobilization. Petition signing is an example of collective action which has gained in popularity with rising use of social media and provides such data for the whole population of petition signatories for a given platform. This paper tracks the growth curves of all 20,000 petitions to the UK government over 18 months, analyzing the rate of growth and outreach mechanism. Previous research has suggested the importance of the first day to the ultimate success of a petition, but has not examined early growth within that day, made possible here through hourly resolution in the data. The analysis shows that the vast majority of petitions do not achieve any measure of success; over 99 percent fail to get the 10,000 signatures required for an official response and only 0.1 percent attain the 100,000 required for a parliamentary debate. We analyze the data through a multiplicative process model framework to explain the heterogeneous growth of signatures at the population level. We define and measure an average outreach factor for petitions and show that it decays very fast (reducing to 0.1% after 10 hours). After 24 hours, a petition's fate is virtually set. The findings seem to challenge conventional analyses of collective action from economics and political science, where the production function has been assumed to follow an S-shaped curve.Comment: Submitted to EPJ Data Scienc

    Practices in applied phonics for grade one.

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    Thesis (Ed.M.)--Boston Universit

    Active Region Moss: Doppler Shifts from Hinode/EIS Observations

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    Studying the Doppler shifts and the temperature dependence of Doppler shifts in moss regions can help us understand the heating processes in the core of the active regions. In this paper we have used an active region observation recorded by the Extreme-ultraviolet Imaging Spectrometer (EIS) onboard Hinode on 12-Dec-2007 to measure the Doppler shifts in the moss regions. We have distinguished the moss regions from the rest of the active region by defining a low density cut-off as derived by Tripathi et al. (2010). We have carried out a very careful analysis of the EIS wavelength calibration based on the method described in Young et al. (2012). For spectral lines having maximum sensitivity between log T = 5.85 and log T = 6.25 K, we find that the velocity distribution peaks at around 0 km/s with an estimated error of 4-5 km/s. The width of the distribution decreases with temperature. The mean of the distribution shows a blue shift which increases with increasing temperature and the distribution also shows asymmetries towards blue-shift. Comparing these results with observables predicted from different coronal heating models, we find that these results are consistent with both steady and impulsive heating scenarios. However, the fact that there are a significant number of pixels showing velocity amplitudes that exceed the uncertainty of 5 km s−1^{-1} is suggestive of impulsive heating. Clearly, further observational constraints are needed to distinguish between these two heating scenarios.Comment: 21 pages (single column), 7 figures, Accepted for Publication in The Astrophysical Journa

    Top-Down Mass Analysis of Protein Tyrosine Nitration: Comparison of Electron Capture Dissociation with “Slow-Heating” Tandem Mass Spectrometry Methods

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    Tyrosine nitration in proteins is an important post-translational modification (PTM) linked to various pathological conditions. When multiple potential sites of nitration exist, tandem mass spectrometry (MS/MS) methods provide unique tools to locate the nitro-tyrosine(s) precisely. Electron capture dissociation (ECD) is a powerful MS/MS method, different in its mechanisms to the “slow-heating” threshold fragmentation methods, such as collision-induced dissociation (CID) and infrared multiphoton dissociation (IRMPD). Generally, ECD provides more homogeneous cleavage of the protein backbone and preserves labile PTMs. However recent studies in our laboratory demonstrated that ECD of doubly charged nitrated peptides is inhibited by the large electron affinity of the nitro group, while CID efficiency remains unaffected by nitration. Here, we have investigated the efficiency of ECD versus CID and IRMPD for top-down MS/MS analysis of multiply charged intact nitrated protein ions of myoglobin, lysozyme, and cytochrome c in a commercial Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. CID and IRMPD produced more cleavages in the vicinity of the sites of nitration than ECD. However the total number of ECD fragments was greater than those from CID or IRMPD, and many ECD fragments contained the site(s) of nitration. We conclude that ECD can be used in the top-down analysis of nitrated proteins, but precise localization of the sites of nitration may require either of the “slow-heating” methods

    Complete eigenstates of identical qubits arranged in regular polygons

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    We calculate the energy eigenvalues and eigenstates corresponding to coherent single and multiple excitations of an array of N identical qubits or two-level atoms (TLA's) arranged on the vertices of a regular polygon. We assume only that the coupling occurs via an exchange interaction which depends on the separation between the qubits. We include the interactions between all pairs of qubits, and our results are valid for arbitrary distances relative to the radiation wavelength. To illustrate the usefulness of these states, we plot the distance dependence of the decay rates of the n=2 (biexciton) eigenstates of an array of 4 qubits, and tabulate the biexciton eigenvalues and eigenstates, and absorption frequencies, line widths, and relative intensities for polygons consisting of N=2,...,9 qubits in the long-wavelength limit.Comment: Added a figure showing how these results can be used to compute deviations from "equal collective decoherence" approximation
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