A Labdane Diterpene from Enicosanthum congregatum

A labdane diterpene was isolated from the air-dried leaves of Enicosanthum congregatum. The structure has been established as 8,I6-dihydroxy-ent-Iabd-13en- 15-oic lactone on the basis of spectroscopic data

Bioactive Natural Products

Bioactive natural products have never ceased to play an important role in the search of novel therapeutic agents. Natural products from the nature such as the plant and marine sources form an integral part of the living system, and they have existed ever since the beginning of life. Therefore, it is undeniable that works related to natural products continue to develop in many aspects involving researchers from various scientific backgrounds. This special issue is dedicated to compile twelve articles on chemical and biological aspects of research developments in natural products

A Mixed Model Study on Perception Towards Outcome Based Education from Graduating Scholars in a Private University

Outcome-Based Education (OBE) is now identified as essential to excellence in education. OBE can be described as the transparent application of a set of measurable criteria in setting a standard of proficiency. The students’ perception is the most crucial part as they are the medium of the system, as they are the ones who undergo the system thoroughly, and are the final product of the OBE system. Thus, their perception will directly show the effectiveness of the OBE system. This study focused on students’ perception on OBE system that had been applied in KPJ Healthcare University College (KPJUC) since 2014, in terms of students’ understanding and academic achievement. This is a mixed model study, which consisted of quantitative and qualitative study. A descriptive method of analysis was used, wherein the quantitative data were gathered using questionnaires and a survey interview was done as a qualitative supplementary data. The findings of this study discovered that the students have a positive perception toward the system

(20S)-22-Iodo­methyl-6β-meth­oxy-3α,5-dihydro-3′H-cyclo­propa[3α,5]-5α-pregnane

In the title steroid derivative, C23H37IO, the fused cyclo­propane unit that comprises part of the A ring has a β-configuration, and the associated cyclo­pentane ring has an envelope conformation

(8S,9R,10S,11S,13S,14S,16S,17R)-4,4-Dichloro-16β-methyl-3,20-dioxo-17,21-bis­(propano­yloxy)-5β,8β-epoxy­pregna-1,9-diene

The title compound, C28H34Cl2O7, is a derivative of the glucocorticoid steroid beclomethasone dipropionate. It features an expoxide linkage [angle at oxygen = 96.6 (2)°]. The dichlorocyclohexenone ring adopts an envelope conformation, with the C atom bearing the two Cl substituents representing the flap. The dichloro­methyl C atom deviates by 0.471 (4) Å from the plane defined by the other five atoms, whose maximum r.m.s. deviation is 0.04 Å

Cholinesterase Enzymes Inhibitors from the Leaves of Rauvolfia Reflexa and Their Molecular Docking Study

molecule

Chemical Components from the Light Petroleum Soluble Fraction of Uvaria cordata (Dunal) Alston

Chromatographic separation of the light petroleum extract from the stem bark of Uvaria cordata (Dunal) Alston led to the isolation of the triterpenoids glutinol and taraxerol in addition to the cyclohexene derivatives, pipoxide and its chlorohydrin. A small amount of benzyl benzoate was also isolated

Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts

The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart

EFEKTIFITAS HOTS DAN PROBLEM BASED LEARNING PADA PEMBELAJARAN TEMATIK SEKOLAH DASAR DI ERA PANDEMI COVID 19

Pembelajaran tematik merupakan pembelajaran yang dilakukan berdasarkan sebuah tema yang dipakai untuk memadukan beberapa topik pembelajran. Hal ini bertujuan agar proses pembelajaran yang dilakukan oleh siswa dapat berjalan dengan mudah karena hal tersebut dimulai dari pembahasan 1 (satu) tema untuk beberapa topik pembelajaran yang diajarkan. Metode penelitian ini memakai jenis penelitian studi kasus yang didalamnya berisi identifikasi efektifitas pembelajaran tematik pada masa pandemi covid 19. Hasil dari penelitian ini mengatakan bahwa pelaksanaan pembelajaran tematik telah dilakukan dengan benar sesuai sintaks dan ketentuan pembelajaran tematik. Pembelajaran tematik yang diberikan pada siswa sudah didesain untuk merangsang dan mengasah kemampuan befikir tingkat tinggi (HOTS) siswa Kata Kunci: HOTS; Problem based Learning; Pembelajaran Temati