Management of erectile dysfunction post-radical prostatectomy

© 2015 Saleh et al.Radical prostatectomy is a commonly performed procedure for the treatment of localized prostate cancer. One of the long-term complications is erectile dysfunction. There is little consensus on the optimal management; however, it is agreed that treatment must be prompt to prevent fibrosis and increase oxygenation of penile tissue. It is vital that patient expectations are discussed, a realistic time frame of treatment provided, and treatment started as close to the prostatectomy as possible. Current treatment regimens rely on phosphodiesterase 5 inhibitors as a first-line therapy, with vacuum erection devices and intraurethral suppositories of alprostadil as possible treatment combination options. With nonresponders to these therapies, intracavernosal injections are resorted to. As a final measure, patients undergo the highly invasive penile prosthesis implantation. There is no uniform, objective treatment program for erectile dysfunction post-radical prostatectomy. Management plans are based on poorly conducted and often underpowered studies in combination with physician and patient preferences. They involve the aforementioned drugs and treatment methods in different sequences and doses. Prospective treatments include dietary supplements and gene therapy, which have shown promise with there proposed mechanisms of improving erectile function but are yet to be applied successfully in human patients

Efficient Ultrasound Image Analysis Models with Sonographer Gaze Assisted Distillation.

Recent automated medical image analysis methods have attained state-of-the-art performance but have relied on memory and compute-intensive deep learning models. Reducing model size without significant loss in performance metrics is crucial for time and memory-efficient automated image-based decision-making. Traditional deep learning based image analysis only uses expert knowledge in the form of manual annotations. Recently, there has been interest in introducing other forms of expert knowledge into deep learning architecture design. This is the approach considered in the paper where we propose to combine ultrasound video with point-of-gaze tracked for expert sonographers as they scan to train memory-efficient ultrasound image analysis models. Specifically we develop teacher-student knowledge transfer models for the exemplar task of frame classification for the fetal abdomen, head, and femur. The best performing memory-efficient models attain performance within 5% of conventional models that are 1000× larger in size

A ducted wind turbine simulation model for building simulation

Power production is shifting away from centralized generation plants to production of heat and power at the point of demand. A technology that may play a part in this shift is the ducted wind turbine (DWT). The emergence of small building integrated micro turbines opens up the possibility of utilizing the differential pressures occurring around buildings for local power production. This paper describes work to develop and test a simple mathematical model of a ducted wind turbine and its integration within a building simulation tool. A case study in which the simulation model will be used to analyse of the likely power output from a building incorporating ducted wind turbines within the façade is also presented

Metallopanstimulin as a marker for head and neck cancer

BACKGROUND: Metallopanstimulin (MPS-1) is a ribosomal protein that is found in elevated amounts in the sera of patients with head and neck squamous cell carcinoma (HNSCC). We used a test, denoted MPS-H, which detects MPS-1 and MPS-1-like proteins, to determine the relationship between MPS-H serum levels and clinical status of patients with, or at risk for, HNSCC. PATIENTS AND METHODS: A total of 125 patients were prospectively enrolled from a university head and neck oncology clinic. Participants included only newly diagnosed HNSCC patients. Two control groups, including 25 non-smokers and 64 smokers, were studied for comparison. A total of 821 serum samples collected over a twenty-four month period were analyzed by the MPS-H radioimmunoassay. RESULTS: HNSCC, non-smokers, and smokers had average MPS-H values of 41.5 ng/mL, 10.2 ng/mL, and 12.8 ng/mL, respectively (p = 0.0001). CONCLUSION: We conclude that MPS-1 and MPS-1-like proteins are elevated in patients with HNSCC, and that MPS-H appears to be a promising marker of presence of disease and response to treatment in HNSCC patients

Quenching and Propagation of Combustion Without Ignition Temperature Cutoff

We study a reaction-diffusion equation in the cylinder $\Omega = \mathbb{R}\times\mathbb{T}^m$, with combustion-type reaction term without ignition temperature cutoff, and in the presence of a periodic flow. We show that if the reaction function decays as a power of $T$ larger than three as $T\to 0$ and the initial datum is small, then the flame is extinguished -- the solution quenches. If, on the other hand, the power of decay is smaller than three or initial datum is large, then quenching does not happen, and the burning region spreads linearly in time. This extends results of Aronson-Weinberger for the no-flow case. We also consider shear flows with large amplitude and show that if the reaction power-law decay is larger than three and the flow has only small plateaux (connected domains where it is constant), then any compactly supported initial datum is quenched when the flow amplitude is large enough (which is not true if the power is smaller than three or in the presence of a large plateau). This extends results of Constantin-Kiselev-Ryzhik for combustion with ignition temperature cutoff. Our work carries over to the case $\Omega = \mathbb{R}^n\times\mathbb{T}^m$, when the critical power is $1 + 2/n$, as well as to certain non-periodic flows

Relating Spin Foams and Canonical Quantum Gravity: A Discrete Step Evolution Formulation of Spin Foams

This article has been replaced by gr-qc/0412011Comment: This article has been replaced by gr-qc/041201

Group-theoretical approach to a non-central extension of the Kepler-Coulomb problem

Bound and scattering states of a non-central extension of the three-dimensional Kepler-Coulomb Hamiltonian are worked out analytically within the framework of the potential groups of the problem, SO(7) for bound states and SO(6,1) for scattering states. In the latter case, the S matrix is calculated by the method of intertwining operators.Comment: 12 pages, to appear in J. Phys. A : Math. Theo

Retail Resilience and Social Media Opinion Mining

This research focuses on the usefulness of social media opinion mining in the retail sector and what constitutes an attractive high-street retail centre from the viewpoint of a consumer. Geo-located Twitter data allows us to establish when, where and what people say about different retail centres. Comparing this data with retail centres of differing vitality could allow us to draw conclusions about how useful and predictive this source could be. Initial analysis revealed some contrasting text content within top ranked and bottom ranked retail centres in Greater London

Power Spectrum of Velocity Fluctuations in the Universe

We investigate the power spectrum of velocity fluctuations in the universe, $V^2(k)$, starting from four different measures of velocity: (1) the power spectrum of velocity fluctuations from peculiar velocities of galaxies; (2) the rms peculiar velocity of galaxy clusters; (3) the power spectrum of velocity fluctuations from the power spectrum of density fluctuations in the galaxy distribution; (4) and the bulk velocity from peculiar velocities of galaxies. We show that measures (1) and (2) are not consistent with each other and either the power spectrum from peculiar velocities of galaxies is overestimated or the rms cluster peculiar velocity is underestimated. The amplitude of velocity fluctuations derived from the galaxy distribution (measure 3) depends on the parameter $\beta$. We estimate the parameter $\beta$ on the basis of measures (2) and (4). The power spectrum of velocity fluctuations from the galaxy distribution in the Stromlo-APM redshift survey is consistent with the observed rms cluster velocity and with the observed large-scale bulk flow when the parameter $\beta$ is in the range 0.4-0.5. In this case the value of the function $V(k)$ at wavelength $\lambda=120h^{-1}$Mpc is $\sim 350$ km s$^{-1}$ and the rms amplitude of the bulk flow at the radius $r=60h^{-1}$ Mpc is $\sim 340$ km s$^{-1}$. The velocity dispersion of galaxy systems originates mostly from the large-scale velocity fluctuations with wavelengths $\lambda >100h^{-1}$ Mpc.Comment: Astrophysical Journal, Vol. 493, in press: 23 pages, uses AAS Latex, and 14 separate postscript figure