Automotive Controller Area Network (CAN) Bus Intrusion Dataset v2

This dataset contains automotive Controller Area Network (CAN) bus data from three systems: two cars (Opel Astra and Renault Clio) and from a CAN bus prototype we built ourselves. Its purpose is meant to evaluate CAN bus Network Intrusion Detection Systems (NIDS). For each system, the dataset consists in a collection of log files captured from its CAN bus: normal (attack-free) data for training and testing detection algorithms, and different CAN bus attacks (Diagnostic, Fuzzing attacks, Replay attack, Suspension attack and Denial-of-Service attack)

Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY-ESO-1 have potent anti-tumor activity.

The cancer-testis antigen NY-ESO-1 has been targeted as a tumor-associated antigen by immunotherapeutical strategies, such as cancer vaccines. The prerequisite for a T-cell-based therapy is the induction of T cells capable of recognizing the NY-ESO-1-expressing tumor cells. In this study, we generated human T lymphocytes directed against the immunodominant NY-ESO-1(157-165) epitope known to be naturally presented with HLA-A*0201. We succeeded to isolate autorestricted and allorestricted T lymphocytes with low, intermediate or high avidity TCRs against the NY-ESO-1 peptide. The avidity of the established CTL populations correlated with their capacity of lysing HLA-A2-positive, NY-ESO-1-expressing tumor cell lines derived from different origins, e.g. melanoma and myeloma. The allorestricted NY-ESO-1-specific T lymphocytes displayed TCRs with the highest avidity and best anti-tumor recognition activity. TCRs derived from allorestricted, NY-ESO-1-specific T cells may be useful reagents for redirecting primary T cells by TCR gene transfer and, therefore, may facilitate the development of adoptive transfer regimens based on TCR-transduced T cells for the treatment of NY-ESO-1-expressing hematological malignancies and solid tumors

Carbonate platform facies reflected in carbonate basin facies (Triassic, northern Calcareous Alps, Austria)

A 95 m long section (Lacke section) located in the Norther Calcareous Alps of Austria was analyzed in detail. Detailed field measurements and point-counting of thin-sections revealed a distinct compositional variation of calciturbidites deposited in the Triassic Hallstatt Basin (Pedata-Pötschen Schichten). After a pilot study seven point-count groups were developed distinguishing input from different paleoenvironments. Statistical analysis of the point-count data using summary statistics, cluster-and correspondence analysis assisted in describing the compositional variation within the calcuturbidites. Alternated flooding and exposure of the platform as a result of sealevel fluctuations, creating and destroying shallow-water habitats on the flat platform top, produced the variations in turbidite composition