QBO of the Equatorial-Stratospheric Winds Revisited: New methods to verify the dominance of 28-month cycle

The equatorial-stratospheric wind that shows a Quasi Biennial Oscillation (22-32 months) has been revisited using a dual statistical detail regarding the search of the dominance harmonics. Data were used from the Freie Universitat of Berlin since 1953 for different heights combining the observations of the three radiosonde stations. The dominant period of 28 months has been reaffirmed but with a discernible amplitude and a phase, respectively, inversely varying with height. Such a cycle suggests an estimate for the coming easterly equatorial wind occurrence at 15 hPa level at the end of 2009. The 28-month harmonic is found to take about a year to descend from 15 to 70 hPa with a progressive lag of about 1 month/km. At the top of the stratosphere, easterlies dominate, while at the bottom, westerlies are more likely to be found. Correlation with sunspot numbers and seasonal rainfall is discussed

Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation.

Recent studies support the potential application of the wt-p53 gene in cancer therapy. Expression of exogenous wt-p53 suppresses a variety of leukaemia phenotypes by acting on cell survival, proliferation and/or differentiation. As for tumour gene therapy, the final fate of the neoplastic cells is one of the most relevant points. We examined the effects of exogenous wt-p53 gene expression in several leukaemia cell lines to identify p53-responsive leukaemia. The temperature-sensitive p53Val135 mutant or the human wt-p53 cDNA was transduced in leukaemia cell lines representative of different acute leukaemia FAB subtypes, including M1 (KG1), M2 (HL-60), M3 (NB4), M5 (U937) and M6 (HEL 92.1.7), as well as blast crisis of chronic myelogenous leukaemia (BC-CML: K562, BV173) showing diverse differentiation features. By morphological, molecular and biochemical analyses, we have shown that exogenous wt-p53 gene expression induces apoptosis only in cells corresponding to M1, M2 and M3 of the FAB classification and in BC-CML showing morphological and cytochemical features of undifferentiated blast cells. In contrast, it promotes differentiation in the others. Interestingly, cell responsiveness was independent of the vector used and the status of the endogenous p53 gene

Quantifying the Multivariate ENSO Index (MEI) coupling to CO2 concentration and to the length of day variations

The El Ni\~no Southern Oscillation (ENSO) is the Earth's strongest climate fluctuation on inter-annual time-scales and has global impacts although originating in the tropical Pacific. Many point indices have been developed to describe ENSO but the Multivariate ENSO Index (MEI) is considered the most representative since it links six different meteorological parameters measured over the tropical Pacific. Extreme values of MEI are correlated to the extreme values of atmospheric CO2 concentration rate variations and negatively correlated to equivalent scale extreme values of the length of day (LOD) rate variation. We evaluate a first order conversion function between MEI and the other two indexes using their annual rate of variation. The quantification of the strength of the coupling herein evaluated provides a quantitative measure to test the accuracy of theoretical model predictions. Our results further confirm the idea that the major local and global Earth-atmosphere system mechanisms are significantly coupled and synchronized to each other at multiple scales.Comment: Theoretical Applied Climatology (2012

On the dominance of 28-month cycle in the equatorial-stratospheric Quasi Biennal Oscillation

The Quasi Biennal Oscillation, the downward propagating easterly and westerly wind regimes in the equatorial stratosphere, has been investigated according to robust statistics providing the reliability of the examined harmonics. The amplitude-to-noise ratio is found to be highest in correspondence of the 28- month harmonic for each examined height; the relative amplitude and phase values are found, respectively, to decrease and increase with the height and to take about a year to descend from 15 to 70 hPa with a progressive lag of about 1 month/km. At the top of the stratosphere, easterlies dominate, while at the bottom, westerlies are more likely to be found

The El Nino events: their classification and scale invariance laws

Classification of highest MEI events, typical of El Nino events, according to Dust cantor algorith

On the 60-month cycle of multivariate ENSO index

Many point indices have been developed to describe El Niño/Southern Oscillation but the Multivariate El Niño Southern Oscillation (ENSO) Index (MEI) is considered the most representative since it links six different meteorological parameters measured over the tropical Pacific. Spectral analysis with appropriate data reduction techniques of monthly values of MEI (1950-2008) has allowed the identification of a large 60-month cycle, statistically confident at a level larger than 99%. The highest values of MEI (typical of El Niño events) and the lowest values of MEI (typical of La Niña events) are concordant with respective maxima and minima values of the identified 60-month cycle