Sporadic porphyria cutanea tarda due to haemochromatosis

Haemochromatosis is a hereditary iron-overload syndrome caused by increased intestinal iron absorption and characterised by accumulation of potentially toxic iron in the tissues. Sometimes this disease presents as a cutanea porphyria. We describe a patient with joint complaints and blistering skin lesions on sun-exposed skin. After identifying the porphyria cutanea tarda by urine analysis we found that the serum activity of uroporphyrinogen decarboxylase (UROD) was normal, meaning a partial inactivation of UROD in liver tissue due to external factors. Further investigation showed the homozygous Cys282Tyr missense mutation and high levels of serum ferritin. It is important to recognise the symptoms of iron overloading at an early stage because hereditary haemochromatosis needs to be treated immediately. We therefore advocate routine sampling of ferritin levels in patients with unexplained joint complaints

Sensitive Limits on the Water Abundance in Cold Low Mass Molecular Cores

We present SWAS observations of water vapor in two cold star-less clouds, B68 and Core D in rho Ophiuchus. Sensitive non-detections of the 1(10)-1(01) transition of o-H2O are reported for each source. Both molecular cores have been previously examined by detailed observations that have characterized the physical structure. Using these rather well defined physical properties and a Monte-Carlo radiation transfer model we have removed one of the largest uncertainties from the abundance calculation and set the lowest water abundance limit to date in cold low-mass molecular cores. These limits are < 3 x 10^{-8} (relative to H2) and < 8 x 10^{-9} in B68 and rho Oph D, respectively. Such low abundances confirm the general lack of ortho-water vapor in cold (T < 20 K) cores. Provided that the ortho/para ratio of water is not near zero, these limits are well below theoretical predictions and appear to support the suggestion that most of the water in dense low-mass cores is frozen onto the surfaces of cold dust grains.Comment: 12 pages, 3 figures, accepted by Astrophysical Journal Letter

Seed quality of high protein corn lines in low input and conventional farming systems

Seed quality is a major issue for crop establishment especially in low input farming systems, where varieties often grow under more stressful conditions than in conventional farming systems. Corn (Zea mays L.) seed for organic (low input) production will eventually need to be grown organically, thus research is needed to ensure excellent seed quality in organic corn seed production. The objective of this study was to compare seed quality and composition differences between a group of high protein corn genotypes grown under low input and conventional farming systems, and to compare the relative seed quality of these genotypes to two well known inbreds, B73 or Mo17. Twenty high protein breeding genotypes were planted during two growing seasons in conventional and organic nurseries near Ames, Iowa, to produce seeds for laboratory tests. The germination, saturated cold, accelerated aging, and soak test percentages of seeds produced organically were 5 to 11% lower than for seeds produced conventionally. Protein, measured by near-infrared reflectance, was unaffected by the production location, but the oil content of seeds produced organically was significantly higher (between 0.2 and 0.3% higher) than in the conventional system. Location by genotype interactions for most tests were non significant both years, indicating that genotypes selected for high seed quality in a conventional system will also have high seed quality when grown in a low input, organic system

The origin of runaway stars

Milli-arcsecond astrometry provided by Hipparcos and by radio observations makes it possible to retrace the orbits of some of the nearest runaway stars and pulsars to determine their site of origin. The orbits of the runaways AE Aurigae and mu Columbae and of the eccentric binary iota Orionis intersect each other about 2.5 Myr ago in the nascent Trapezium cluster, confirming that these runaways were formed in a binary-binary encounter. The path of the runaway star zeta Ophiuchi intersects that of the nearby pulsar PSR J1932+1059, about 1 Myr ago, in the young stellar group Upper Scorpius. We propose that this neutron star is the remnant of a supernova that occurred in a binary system which also contained zeta Oph, and deduce that the pulsar received a kick velocity of about 350 km/s in the explosion. These two cases provide the first specific kinematic evidence that both mechanisms proposed for the production of runaway stars, the dynamical ejection scenario and the binary-supernova scenario, operate in nature.Comment: 5 pages, including 2 eps-figures and 1 table, submitted to the ApJ Letters. The manuscript was typeset using aaste

Star formation environments and the distribution of binary separations

We have carried out K-band speckle observations of a sample of 114 X-ray selected weak-line T Tauri stars in the nearby Scorpius-Centaurus OB association. We find that for binary T Tauri stars closely associated to the early type stars in Upper Scorpius, the youngest subgroup of the OB association, the peak in the distribution of binary separations is at 90 A.U. For binary T Tauri stars located in the direction of an older subgroup, but not closely associated to early type stars, the peak in the distribution is at 215 A.U. A Kolmogorov-Smirnov test indicates that the two binary populations do not result from the same distibution at a significance level of 98%. Apparently, the same physical conditions which facilitate the formation of massive stars also facilitate the formation of closer binaries among low-mass stars, whereas physical conditions unfavorable for the formation of massive stars lead to the formation of wider binaries among low-mass stars. The outcome of the binary formation process might be related to the internal turbulence and the angular momentum of molecular cloud cores, magnetic field, the initial temperature within a cloud, or - most likely - a combination of all of these. We conclude that the distribution of binary separations is not a universal quantity, and that the broad distribution of binary separations observed among main-sequence stars can be explained by a superposition of more peaked binary distributions resulting from various star forming environments. The overall binary frequency among pre-main-sequence stars in individual star forming regions is not necessarily higher than among main-sequence stars.Comment: 7 pages, Latex, 4 Postscript figures; also available at http://spider.ipac.caltech.edu/staff/brandner/pubs/pubs.html ; accepted for publication in ApJ Letter

Mid-infrared Imaging of a Circumstellar Disk Around HR 4796: Mapping the Debris of Planetary Formation

We report the discovery of a circumstellar disk around the young A0 star, HR 4796, in thermal infrared imaging carried out at the W.M. Keck Observatory. By fitting a model of the emission from a flat dusty disk to an image at lambda=20.8 microns, we derive a disk inclination, i = 72 +6/-9 deg from face on, with the long axis of emission at PA 28 +/-6 deg. The intensity of emission does not decrease with radius as expected for circumstellar disks but increases outward from the star, peaking near both ends of the elongated structure. We simulate this appearance by varying the inner radius in our model and find an inner hole in the disk with radius R_in = 55+/-15 AU. This value corresponds to the radial distance of our own Kuiper belt and may suggest a source of dust in the collision of cometesimals. By contrast with the appearance at 20.8 microns, excess emission at lambda = 12.5 microns is faint and concentrated at the stellar position. Similar emission is also detected at 20.8 microns in residual subtraction of the best-fit model from the image. The intensity and ratio of flux densities at the two wavelengths could be accounted for by a tenuous dust component that is confined within a few AU of the star with mean temperature of a few hundred degrees K, similar to that of zodiacal dust in our own solar system. The morphology of dust emission from HR 4796 (age 10 Myr) suggests that its disk is in a transitional planet-forming stage, between that of massive gaseous proto-stellar disks and more tenuous debris disks such as the one detected around Vega.Comment: 9 pages, 4 figures as LaTex manuscript and postscript files in gzipped tar file. Accepted for publication in Astrophysical Journal Letters. http://upenn5.hep.upenn.edu/~davidk/hr4796.htm