Brane Worlds, the Cosmological Constant and String Theory

We argue that traditional methods of compactification of string theory make it very difficult to understand how the cosmological constant becomes zero. String inspired models can give zero cosmological constant after fine tuning but since string theory has no free parameters it is not clear that this is allowed. Brane world scenarios on the other hand while they do not answer the question as to why the cosmological constant is zero do actually allow a choice of integration constants that permit flat four space solutions. In this paper we discuss gauged supergravity realizations of such a world. To the extent that this starting point can be considered a low energy effective action of string theory (and there is some recent evidence supporting this) our model may be considered a string theory realization of this scenario.Comment: 18 pages, 5 figures. Shorter version and a few new comments adde

What Do We Mean by “Transformation”?

What is “defense transformation” (by whatever name), and how might it affect strategy? What might it cost, and how could its cost affect military forces? What systemic impediments to implementation does it face, and what are its competitors in the budgetary realm? A distinguished panel of the Secretary of the Navy’s Current Strategy Forum held at the Naval War College on 12–13 June 2001 addressed these issues from various perspectives

Designed for Disease: The Link Between Local Food Environments and Obesity and Diabetes

Examines the link between a community's retail food environment -- the ratio of fast-food outlets and convenience stores to grocery stores and produce vendors, with income level as a factor -- and the prevalence of adult obesity and diabetes

Duality Twists on a Group Manifold

We study duality-twisted dimensional reductions on a group manifold G, where the twist is in a group \tilde{G} and examine the conditions for consistency. We find that if the duality twist is introduced through a group element \tilde{g} in \tilde{G}, then the flat \tilde{G}-connection A =\tilde{g}^{-1} d\tilde{g} must have constant components M_n with respect to the basis 1-forms on G, so that the dependence on the internal coordinates cancels out in the lower dimensional theory. This condition can be satisfied if and only if M_n forms a representation of the Lie algebra of G, which then ensures that the lower dimensional gauge algebra closes. We find the form of this gauge algebra and compare it to that arising from flux compactifications on twisted tori. As an example of our construction, we find a new five dimensional gauged, massive supergravity theory by dimensionally reducing the eight dimensional Type II supergravity on a three dimensional unimodular, non-semi-simple, non-abelian group manifold with an SL(3,R) twist.Comment: 22 page

Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress

Oxidant stress is arguably a universal feature in toxicology. Research studies on the role of oxidant stress induced by xenobiotic exposures have typically relied on the identification of damaged biomolecules using a variety of conventional biochemical and molecular techniques. However, there is increasing evidence that low-level exposure to a variety of toxicants dysregulates cellular physiology by interfering with redox-dependent processes

Quantum Mechanics of the Doubled Torus

We investigate the quantum mechanics of the doubled torus system, introduced by Hull [1] to describe T-folds in a more geometric way. Classically, this system consists of a world-sheet Lagrangian together with some constraints, which reduce the number of degrees of freedom to the correct physical number. We consider this system from the point of view of constrained Hamiltonian dynamics. In this case the constraints are second class, and we can quantize on the constrained surface using Dirac brackets. We perform the quantization for a simple T-fold background and compare to results for the conventional non-doubled torus system. Finally, we formulate a consistent supersymmetric version of the doubled torus system, including supersymmetric constraints.Comment: 31 pages, 1 figure; v2: references added, minor corrections to final sectio

Darkfield-Confocal Microscopy detection of nanoscale particle internalization by human lung cells

<p>Abstract</p> <p>Background</p> <p>Concerns over the health effects of nanomaterials in the environment have created a need for microscopy methods capable of examining the biological interactions of nanoparticles (NP). Unfortunately, NP are beyond the diffraction limit of resolution for conventional light microscopy (~200 nm). Fluorescence and electron microscopy techniques commonly used to examine NP interactions with biological substrates have drawbacks that limit their usefulness in toxicological investigation of NP. EM is labor intensive and slow, while fluorescence carries the risk of photobleaching the sample and has size resolution limits. In addition, many relevant particles lack intrinsic fluorescence and therefore can not be detected in this manner. To surmount these limitations, we evaluated the potential of a novel combination of darkfield and confocal laser scanning microscopy (DF-CLSM) for the efficient 3D detection of NP in human lung cells. The DF-CLSM approach utilizes the contrast enhancements of darkfield microscopy to detect objects below the diffraction limit of 200 nm based on their light scattering properties and interfaces it with the power of confocal microscopy to resolve objects in the z-plane.</p> <p>Results</p> <p>Validation of the DF-CLSM method using fluorescent polystyrene beads demonstrated spatial colocalization of particle fluorescence (Confocal) and scattered transmitted light (Darkfield) along the X, Y, and Z axes. DF-CLSM imaging was able to detect and provide reasonable spatial locations of 27 nm TiO₂particles in relation to the stained nuclei of exposed BEAS 2B cells. Statistical analysis of particle proximity to cellular nuclei determined a significant difference between 5 min and 2 hr particle exposures suggesting a time-dependant internalization process.</p> <p>Conclusions</p> <p>DF-CLSM microscopy is an alternative to current conventional light and electron microscopy methods that does not rely on particle fluorescence or contrast in electron density. DF-CLSM is especially well suited to the task of establishing the spatial localization of nanoparticles within cells, a critical topic in nanotoxicology. This technique has advantages to 2D darkfield microscopy as it visualizes nanoparticles in 3D using confocal microscopy. Use of this technique should aid toxicological studies related to observation of NP interactions with biological endpoints at cellular and subcellular levels.</p

Global Aspects of T-Duality, Gauged Sigma Models and T-Folds

The gauged sigma-model argument that string backgrounds related by T-dual give equivalent quantum theories is revisited, taking careful account of global considerations. The topological obstructions to gauging sigma-models give rise to obstructions to T-duality, but these are milder than those for gauging: it is possible to T-dualise a large class of sigma-models that cannot be gauged. For backgrounds that are torus fibrations, it is expected that T-duality can be applied fibrewise in the general case in which there are no globally-defined Killing vector fields, so that there is no isometry symmetry that can be gauged; the derivation of T-duality is extended to this case. The T-duality transformations are presented in terms of globally-defined quantities. The generalisation to non-geometric string backgrounds is discussed, the conditions for the T-dual background to be geometric found and the topology of T-folds analysed.Comment: Minor corrections and addition

D-branes in T-fold conformal field theory

We investigate boundary dynamics of orbifold conformal field theory involving T-duality twists. Such models typically appear in contexts of non-geometric string compactifications that are called monodrofolds or T-folds in recent literature. We use the framework of boundary conformal field theory to analyse the models from a microscopic world-sheet perspective. In these backgrounds there are two kinds of D-branes that are analogous to bulk and fractional branes in standard orbifold models. The bulk D-branes in T-folds allow intuitive geometrical interpretations and are consistent with the classical analysis based on the doubled torus formalism. The fractional branes, on the other hand, are `non-geometric' at any point in the moduli space and their geometric counterparts seem to be missing in the doubled torus analysis. We compute cylinder amplitudes between the bulk and fractional branes, and find that the lightest modes of the open string spectra show intriguing non-linear dependence on the moduli (location of the brane or value of the Wilson line), suggesting that the physics of T-folds, when D-branes are involved, could deviate from geometric backgrounds even at low energies. We also extend our analysis to the models with SU(2) WZW fibre at arbitrary levels.Comment: 38 pages, no figure, ams packages. Essentially the published versio

Superstring partition functions in the doubled formalism

Computation of superstring partition function for the non-linear sigma model on the product of a two-torus and its dual within the scope of the doubled formalism is presented. We verify that it reproduces the partition functions of the toroidally compactified type--IIA and type--IIB theories for appropriate choices of the GSO projection.Comment: 15 page