Quantitative Analysis of Vasodilatory Action of Quercetin on Intramural Coronary Resistance Arteries of the Rat In Vitro

Background: Dietary quercetin improves cardiovascular health, relaxes some vascular smooth muscle and has been demonstrated to serve as a substrate for the cyclooxygenase enzyme. Aims: 1. To test quantitatively a potential direct vasodilatory effect on intramural coronary resistance artery segments, in different concentrations. 2. To scale vasorelaxation at different intraluminal pressure loads on such vessels of different size. 3. To test the potential role of prostanoids in vasodilatation induced by quercetin. Methods: Coronary arterioles (70-240 mu m) were prepared from 24 rats and pressurized in PSS, using a pressure microangiometer. Results: The spontaneous tone that developed at 50 mmHg was relaxed by quercetin in the 10(-9) moles/lit concentration (p<0.05), while 10(-5) moles/lit caused full relaxation. Significant relaxation was observed at all pressure levels (10-100 mmHg) at 10(-7) moles/lit concentration of quercetin. The cyclooxygenase blocker indomethacin (10(-5) moles/lit) induced no relaxation but contraction when physiological concentrations of quercetin were present in the tissue bath (p<0.02 with Anova), this contraction being more prominent in smaller vessels and in the higher pressure range (p<0.05, Pearson correlation). A further 2-8% contraction could be elicited by the NO blocker L-NAME (10(-4) moles/lit). Conclusion: These results demonstrate that circulating levels of quercetin (10(-7) moles/lit) exhibit a substantial coronary vasodilatory effect. The extent of it is commeasurable with that of several other physiological mechanisms of coronary blood flow control. At least part of this relaxation is the result of an altered balance toward the production of endogenous vasodilatory prostanoids in the coronary arteriole wall

Millimeter-wavelength radiation from arrays of discrete high-temperature superconductor Josephson junctions

Josephson junction arrays could be competitive candidates for radiation sources in the frequency range from 0.5 to 1.5 THz. This is the range where compact solid-state continuous wave sources are most lacking. We investigated the millimeter-wave radiation from arrays of high-temperature superconductor bicrystal Josephson junctions embedded in a quasi-optical resonator. The novel approach of utilizing the intrinsic resonance modes of the substrate to improve the impedance coupling between the series array of discrete Josephson junctions and the quasi-optical resonator was investigated by experiments and electromagnetic field simulations. Radiation from the arrays containing up to 536 junctions was detected at about 80 GHz and liquid nitrogen temperature using a low-noise receiver. The detected maximum radiation power of the arrays was about 50 pW and the peak voltage agreed exactly with the Josephson current-voltage relation