СОВРЕМЕННАЯ МЕТОДИКА ОРГАНИЗАЦИИ ПРОЦЕССА РАЗРАБОТКИ ПРОГРАММ

.В статье рассматривается методика организации процесса разработки программного обеспечения на основе непрерывной интеграции, которая объединяет в единое целое множество техник, облегчающих разработку и сопровождение программ в промышленных масштабах.

Impaired Axonal Transport in Motor Neurons Correlates with Clinical Prion Disease

Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain areas are still poorly understood. The role of nervous system integrity and axonal properties in prion pathology are still elusive. There is no evidence of both the functional axonal impairments in vivo and their connection with prion disease. We studied the functional axonal impairments in motor neurons at the onset of clinical prion disease using the combination of tracing as a functional assay for axonal transport with immunohistochemistry experiments. Well-established and novel confocal and ultramicroscopy techniques were used to image and quantify labeled neurons. Despite profound differences in the incubation times, 30% to 45% of neurons in the red nucleus of different mouse lines showed axonal transport impairments at the disease onset bilaterally after intracerebral prion inoculation and unilaterally—after inoculation into the right sciatic nerve. Up to 94% of motor cortex neurons also demonstrated transport defects upon analysis by alternative imaging methods. Our data connect axonal transport impairments with disease symptoms for different prion strains and inoculation routes and establish further insight on the development of prion pathology in vivo. The alterations in localization of the proteins involved in the retrograde axonal transport allow us to propose a mechanism of transport disruption, which involves Rab7-mediated cargo attachment to the dynein-dynactin pathway. These findings suggest novel targets for therapeutic and diagnostic approaches in the early stages of prion disease

The Small-x Behaviour of the Singlet Polarized Structure Function g_2 in the Double Logarithmic Approximation

The small-x behavior of the singlet contributions to the polarized structure function g_2(x,Q^2) is calculated in the double-logarithmic approximation of perturbative QCD. The dominant contribution is due to the gluons which, in contrast to the unpolarized case, mix with the fermions also in the small-x domain. We find a power-like growth in 1/x in the odd-signature parts of the amplitude with the same power as in the singlet function g_1(x,Q^2) at x<< 1.Comment: 20 pages, latex, 3 ps figure

QCD explanation of oscillating hadron and jet multiplicity moments

Ratios of multiplicity moments, H_q (cumulant over factorial moments K_q/F_q), have been observed to show an oscillatory behaviour with respect to order, q. Recent studies of e^+e^- annihilations at LEP have shown, moreover, that the amplitude and oscillation length vary strongly with the jet resolution parameter y_{cut}. We study the predictions of the perturbative QCD parton cascade assuming low non-perturbative cut-off (Q_0\sim \Lambda_{QCD}\sim few 100 MeV) and derive the expectations as a function of the cms energy and jet resolution from threshold to very high energies. We consider numerical solutions of the evolution equations of gluodynamics in Double Logarithmic and Modified Leading Logarithmic Approximations (DLA,MLLA), as well as results from a parton MC with readjusted parameters. The main characteristics are obtained in MLLA, while a more numerically accurate description is obtained by the MC model. A unified description of correlations between hadrons and correlations between jets emerges, in particular for the transition region of small y_{cut}.Comment: 31 pages, 14 figure

Пространственно-временной компенсатор широкополосных помех на основе метода степенны́х векторов

The article is intended for specialists in the field of electronic warfare and adaptive jammer cancellation. The main advantage of the proposed spatial adaptive broadband compensator is the ability to adaptively estimate the number of active interference for minimizing computational complexity in compare with traditional methods for suppressing wideband interference. The paper presents a strong theoretical derivation of the weight matrix of the auto-compensator. The main approach for calculating the weight matrix is the expansion in powers of vectors in the orthonormal basis. A practical approach for introducing the algorithm into software is proposed.Рассмотрен адаптивный автокомпенсатор широкополосных помех (АКШП), обеспечивающий на выходе минимальную среднюю мощность помех. Предложен алгоритм адаптивного подавления широкополосных помех, основанный на разложении весового вектора АКШП в степенном базисе, обладающий невысокой вычислительной сложностью. Получены регуляризованные оценки весов коэффициентов автокомпенсатора по ограниченному числу выборок входного процесса. Приведены результаты моделирования подавления широкополосных помех, характерных для радиолокации, действующих с различных пространственных направлений, с оценкой коэффициента подавления

A Phenomenological Analysis of Gluon Mass Effects in Inclusive Radiative Decays of the J/ψ\rm{J/\psi} and $\Upsilon

The shapes of the inclusive photon spectra in the processes \Jp \to \gamma X and \Up \to \gamma X have been analysed using all available experimental data. Relativistic, higher order QCD and gluon mass corrections were taken into account in the fitted functions. Only on including the gluon mass corrections, were consistent and acceptable fits obtained. Values of $0.721^{+0.016}_{-0.068}$ GeV and $1.18^{+0.09}_{-0.29}$ GeV were found for the effective gluon masses (corresponding to Born level diagrams) for the \Jp and \Up respectively. The width ratios \Gamma(V \to {\rm hadrons})/\Gamma(V \to \gamma+ {\rm hadrons}) V=\Jp, \Up were used to determine $\alpha_s(1.5 {\rm GeV})$ and $\alpha_s(4.9 {\rm GeV})$. Values consistent with the current world average $\alpha_s$ were obtained only when gluon mass correction factors, calculated using the fitted values of the effective gluon mass, were applied. A gluon mass $\simeq 1$ GeV, as suggested with these results, is consistent with previous analytical theoretical calculations and independent phenomenological estimates, as well as with a recent, more accurate, lattice calculation of the gluon propagator in the infra-red region.Comment: 50 pages, 11 figures, 15 table

Эффективность линейной обработки сигналов в системах связи в условиях многолучевого ионосферного канала декаметрового диапазона

The architecture of digital High Frequency (HF) data modem is considered. Link level simulation of HF wireless communication system with bandwidth of 3 kHz was carried out for the multipath ionospheric channel model. The main link level performance metrics such as BER, PER and system throughput are provided and analyzed. It is shown that in frequency-selective two ray channel, the linear MMSE equalization at the receiver provides efficient ISI elimination for all modulation and coding schemes except high-order modulations that are required development of non-linear quasi-optimal signal processing algorithms.Рассмотрены системы связи декаметрового диапазона, работающие в условиях многолучевого ионосферного пространственного канала. С помощью имитационного моделирования на физическом уровне исследованы основные характеристики системы (вероятность битовой и блоковой ошибки, пропускная способность). Показано, что в условиях частотно-селективного канала в полосе 3 кГц линейный алгоритм эквализации обеспечивает высокую эффективность подавления межсимвольной помехи для всех скоростей передачи данных, кроме самой высокой

Molecular Structure of Amyloid Fibrils Controls the Relationship between Fibrillar Size and Toxicity

According to the prevailing view, soluble oligomers or small fibrillar fragments are considered to be the most toxic species in prion diseases. To test this hypothesis, two conformationally different amyloid states were produced from the same highly pure recombinant full-length prion protein (rPrP). The cytotoxic potential of intact fibrils and fibrillar fragments generated by sonication from these two states was tested using cultured cells.For one amyloid state, fibril fragmentation was found to enhance its cytotoxic potential, whereas for another amyloid state formed within the same amino acid sequence, the fragmented fibrils were found to be substantially less toxic than the intact fibrils. Consistent with the previous studies, the toxic effects were more pronounced for cell cultures expressing normal isoform of the prion protein (PrP(C)) at high levels confirming that cytotoxicity was in part PrP(C)-dependent. Silencing of PrP(C) expression by small hairpin RNAs designed to silence expression of human PrP(C) (shRNA-PrP(C)) diminished the deleterious effects of the two amyloid states to a different extent, suggesting that the role of PrP(C)-mediated and PrP(C)-independent mechanisms depends on the structure of the aggregates.This work provides a direct illustration that the relationship between an amyloid's physical dimension and its toxic potential is not unidirectional but is controlled by the molecular structure of prion protein (PrP) molecules within aggregated states. Depending on the structure, a decrease in size of amyloid fibrils can either enhance or abolish their cytotoxic effect. Regardless of the molecular structure or size of PrP aggregates, silencing of PrP(C) expression can be exploited to reduce their deleterious effects

Private Gold Industry of Kuzbass in Late 19^th - Early 20^th Century

The article is devoted to the history of the gold mining industry of Kuzbass in the late 19th - early 20th century. The purpose of this article is to establish the dynamics of gold mining in the Mariinsky and Kuznetsk taiga, as well as to identify the factors affecting the development of the gold industry in these areas. The results of studying the dynamics of gold mining is presented according to official published surveys in the province of Tomsk and Tomsk archival records of the Mining Department. It is shown that the private gold industry of Kuzbass in the late 19th century had significant differences: in the Kuznetsk taiga there were big companies and firms, and in the Mariinsky taiga - small ones. It is emphasized that in the Kuznetsk uezd gold mining was 3-4 times higher than in the Mariinsky. It is concluded that over time the situation has changed dramatically: before the First World War the gold industry in Kuznetsk uezd had decreased several times, and in the Mariinsky uezd, on the contrary, had grown more than 2 times. It is proved that the growth of the gold industry in the Mariinsky taiga is associated with the use of new technologies (the use of drag) and the beginning of the development of ore deposits. In the Kuznetsk uezd drags were not used, and ore deposits were not found. The author notes that the development of the gold industry in the Mariinsky uezd was facilitated by the construction of the Siberian railway, which passed through Mariinsk