[Hemorrhagic syndrome and isolated alpha 2-antiplasmin deficiency. Apropos of a case].

International audienceAn isolated alpha 2 plasmin inhibitor deficiency is reported in a 33 years old male, presenting repeated intramuscular hematomas since 5 years, spontaneously or after minor traumas. None of other family members were suffering from abnormal bleeding. Screening hemostatic examinations were normal except for a moderately shorted euglobulin lysis time (2 hours). Evaluation of fibrinolysis parameters (plasminogen, plasminogen activator inhibitor type 1, tissue plasminogen activator, fibrin and fibrinogen degradation products, alpha 2 plasmin inhibitor) showed normal values except for alpha 2 plasmin inhibitor which is markedly decreased (activity: 14%, antigen: < 5%). Familial hemostasis investigations have not been performed. This isolated alpha 2 plasmin inhibitor deficiency has been confirmed by two repeated control prelevments. Bleedings episodes were treated with antifibrinolytics agents (tranexamic acid). This case report shows the importance of the diagnostic approach in the laboratory to detect such rare hemostatic abnormalities associated with bleeding tendency

Estimation des périodicités et de la tendance des températures moyennes mensuelles en Tunisie

Data of monthly mean temperatures collected between 1901 and 1988 at six meteorological stations in Tunisia have been studied to estimate their dominant periodicities and their trends. One significant periodicity of 12 months was found in the original series by using the method developed by Siddiqui and Wang (1984). Kendall's rank correlation test showed no significant trends in these series

Contribution of Flow Cytometry to Acute Leukemia Classification in Tunisia

The precision of immunological characterization of leukemias was improved by a certain number of technical innovations, particularly hybridoma production and standardization, resulting in monoclonal antibodies and definition of recognised cellular antigens (designated by CD: Cluster of Differentiation)