SCENE AND OBJECT CLASSIFICATION USING BRAIN WAVES SIGNAL

This study aims to classify the scene and object using brain waves signal. The dataset captured by the electroencephalograph (EEG) device by placing the electrodes on scalp to measure brain signals are used. Using captured EEG dataset, classifying the scene and object by decoding the changes in the EEG signals. In this study, independent component analysis, event-related potentials, and grand mean are used to analyze the signal. Machine learning algorithms such as decision tree, random forest, and support vector machine are used to classify the data. This technique is useful in forensic as well as in artificial intelligence for developing future technology.Â

Kaempferol-Phospholipid Complex: Formulation, and Evaluation of Improved Solubility, In Vivo Bioavailability, and Antioxidant Potential of Kaempferol

The current work describes the formulation and evaluation of a phospholipid complex of kaempferol toenhance the latter’s aqueous solubility, in vitro dissolution rate, in vivo antioxidant and hepatoprotectiveactivities, and oral bioavailability. The kaempferol-phospholipid complex was synthesized using a freeze-drying method with the formulation being optimized using a full factorial design (32) approach. The resultsinclude the validation of the mathematical model in order to ascertain the role of specific formulation andprocess variables that contribute favorably to the formulation’s development. The final product wascharacterized and confirmed by Differential Scanning Calorimetry (DSC), Fourier Transform InfraredSpectroscopy (FTIR), Proton Nuclear Magnetic Resonance Spectroscopy (1H-NMR), and Powder X-rayDiffraction (PXRD) analysis. The aqueous solubility and the in vitro dissolution rate were enhanced comparedto that of pure kaempferol. The in vivo antioxidant properties of the kaempferol-phospholipid complex wereevaluated by measuring its impact on carbon tetrachloride (CCl4)-intoxicated rats. The optimizedphospholipid complex improved the liver function test parameters to a significant level by restoration of allelevated liver marker enzymes in CCl4-intoxicated rats. The complex also enhanced the in vivo antioxidantpotential by increasing levels of GSH (reduced glutathione), SOD (superoxide dismutase), catalase anddecreasing lipid peroxidation, compared to that of pure kaempferol. The final optimized phospholipidcomplex also demonstrated a significant improvement in oral bioavailability demonstrated by improvementsto key pharmacokinetic parameters, compared to that of pure kaempferol

Communication interventions to promote the public's awareness of antibiotics: a systematic review.

BackgroundInappropriate antibiotic use is implicated in antibiotic resistance and resultant morbidity and mortality. Overuse is particularly prevalent for outpatient respiratory infections, and perceived patient expectations likely contribute. Thus, various educational programs have been implemented to educate the public.MethodsWe systematically identified public-directed interventions to promote antibiotic awareness in the United States. PubMed, Google Scholar, Embase, CINAHL, and Scopus were queried for articles published from January 1996 through January 2016. Two investigators independently assessed titles and abstracts of retrieved articles for subsequent full-text review. References of selected articles and three review articles were likewise screened for inclusion. Identified educational interventions were coded for target audience, content, distribution site, communication method, and major outcomes.ResultsOur search yielded 1,106 articles; 34 met inclusion criteria. Due to overlap in interventions studied, 29 distinct educational interventions were identified. Messages were primarily delivered in outpatient clinics (N = 24, 83%) and community sites (N = 12, 41%). The majority included clinician education. Antibiotic prescription rates were assessed for 22 interventions (76%). Patient knowledge, attitudes, and beliefs (KAB) were assessed for 10 interventions (34%). Similar rates of success between antibiotic prescription rates and patient KAB were reported (73 and 70%, respectively). Patient interventions that did not include clinician education were successful to increase KAB but were not shown to decrease antibiotic prescribing. Three interventions targeted reductions in Streptococcus pneumoniae resistance; none were successful.ConclusionsMessaging programs varied in their designs, and many were multifaceted in their approach. These interventions can change patient perspectives regarding antibiotic use, though it is unclear if clinician education is also necessary to reduce antibiotic prescribing. Further investigations are needed to determine the relative influence of interventions focusing on patients and physicians and to determine whether these changes can influence rates of antibiotic resistance long-term

Revisiting Langer-Ambegaokar-McCumber-Halperin theory of resistive transitions in one-dimensional superconductors with exact solutions

We present an important correction to the Langer-Ambegaokar-McCumber-Halperin theory for the resistive state of a 1D superconductor. We establish that the identification of the saddle on the free energy surface over which Langer and Ambegaokar had claimed the system to move in order to form thermally excited phase slip centres is wrong. With the help of an exact solution we show that the system has to overcome a similar free energy barrier but can actually have vanishing amplitude of superconducting phase at a point unlike the Langer-Ambegaokar solution

Complete Genomic Sequences of Three Salmonella enterica subsp. enterica Serovar Muenchen Strains from an Orchard in San Joaquin County, California.

We present here the complete genome sequences of three Salmonella enterica subsp. enterica serovar Muenchen strains, LG24, LG25, and LG26. All three strains were isolated from almond drupes grown in an orchard in San Joaquin County, California, in 2016. These genomic sequences are nonidentical and will contribute to our understanding of S. enterica genomics

Posterior capsular infiltration with local anaesthetic cocktail during total knee arthroplasty: a prospective comparative study

Background: Total knee arthroplasty offers a stable joint with excellent long-term results in osteoarthritis knee patients. The procedure is also associated with post-operative pain which can lead to delayed functional recovery in few patients. This comparative study was aimed to evaluate the effiсасy of а lосаl anaesthetic сосktаil injection with and without роsteriоr сарsulаr infiltration for роst-орerаtive раin соntrоl and early functional reсоvery in раtients undergoing simultaneous bilateral TKА.Methods: This was a prospective comparative study which involved 50 participants undergoing bilateral TKA where one knee, received LIA in anterior, medial and lateral structures of the knee as well as posterior capsule (group A) and contralateral knee received LIA in anterior, medial and lateral structures, identical to the former knee, but excluding posterior capsule region (group B). Pre-operative and post-operative parameters such as VAS, KSS and knee ROM in both knees of all the patients were noted and compared to evaluate the efficacy of PCI.Results: Comparison of VAS scores, post-operatively showed that VAS on rest and on movement was lower in group A than group B at all the time frames (p value <0.0001*). Post-operative knee ROM was higher in group A (p<0.0001). Knee society score was observed to be higher in group A than group B on 15th day and at 1 month (p<0.0001).Conclusions: The study successfully demonstrates that posterior capsular infiltration when included in LIA technique provides a better pain control and also early functional recovery after TKA

Calvarial bone defect regeneration using beta-tricalcium phosphate: a translational research study in rat animal model

Background: Guided bone regeneration (GBR) using osteoconductive graft materials has been used for osseous defect healing. The aim of this translational research study was to design and test a critical size calvarial defect (CSD) model in rats, to test GBR with beta-tricalcium phosphate (beta-TCP), using histology and micro computed tomography (micro-CT) assessment.Methods: Female Wistar albino rats (n=10) weighing 300 grams and aged 6-weeks were used and full thickness CSD were created in calvaria following exposure under general anesthesia. CSD were randomly divided into two groups for treatment, based on defect filling material: control group (no graft placed in defect; n=5); and beta-TCP group (defect grafted with beta-TCP; n=5). Both defects were covered with collagen membrane. After 8-weeks of healing the animals were sacrificed and calvarial specimens were subjected to micro-CT and histological assessment.Results: Based on micro-CT the new bone volume (NBV) was significantly higher in beta-TCP group (3.48±0.27 mm3; p<0.05), than control group (2.88±0.33 mm3). Similarly, new bone mineral density (NBMD) was significantly higher in beta-TCP group (0.426±0.018 g/mm3; p<0.01), than control group (0.243±0.015 g/mm3). Histology revealed greater new bone bridging the entire defect with interspersed graft particles in the beta-TCP group.Conclusions: Within the limitations of the present study, GBR of rat calvarial CSD with beta-TCP and collagen membrane, results in significantly higher NBV and NBMD, and is a reliable and reproducible translational research model

Magnetoelectricity at room temperature in Bi0.9-xTbxLa0.1FeO3 system

Magnetoelectric compounds with the general formula, Bi0.9-xRxLa0.1FeO3 (R =Gd, Tb, Dy, etc.), have been synthesized. These show the coexistence of ferroelectricity and magnetism, possess high dielectric constant and exhibit magnetoelectric coupling at room temperature. Such materials may be of great significance in basic as well as applied research.Comment: 11 pages of text and figure