Proposed common exchange format for development activity information

Meeting: Informal Study Group on Exchange of Devlopment Information, General Meeting, 1st, 19-21 June 1991, Paris, F

Seismic retrofit of an existing reinforced concrete building with buckling-restrained braces

Background: The seismic retrofitting of frame structures using hysteretic dampers is a very effective strategy to mitigate earthquake-induced risks. However, its application in current practice is rather limited since simple and efficient design methods are still lacking, and the more accurate time-history analysis is time-consuming and computationally demanding. Aims: This paper develops and applies a seismic retrofit design method to a complex real case study: An eight-story reinforced concrete residential building equipped with buckling-restrained braces. Methods: The design method permits the peak seismic response to be predicted, as well as the dampers to be added in the structure to obtain a uniform distribution of the ductility demand. For that purpose, a pushover analysis with the first mode load pattern is carried out. The corresponding story pushover curves are first idealized using a degrading trilinear model and then used to define the SDOF (Single Degree-of-Freedom) system equivalent to the RC frame. The SDOF system, equivalent to the damped braces, is designed to meet performance criteria based on a target drift angle. An optimal damper distribution rule is used to distribute the damped braces along the elevation to maximize the use of all dampers and obtain a uniform distribution of the ductility demand. Results: The effectiveness of the seismic retrofit is finally demonstrated by non-linear time-history analysis using a set of earthquake ground motions with various hazard levels. Conclusion: The results proved the design procedure is feasible and effective since it achieves the performance objectives of damage control in structural members and uniform ductility demand in dampers

The ethics of people analytics: risks, opportunities and recommendations

Purpose: This research analyzed the existing academic and grey literature concerning the technologies and practices of people analytics (PA), to understand how ethical considerations are being discussed by researchers, industry experts and practitioners, and to identify gaps, priorities and recommendations for ethical practice. Design/methodology/approach: An iterative “scoping review” method was used to capture and synthesize relevant academic and grey literature. This is suited to emerging areas of innovation where formal research lags behind evidence from professional or technical sources. Findings: Although the grey literature contains a growing stream of publications aimed at helping PA practitioners to “be ethical,” overall, research on ethical issues in PA is still at an early stage. Optimistic and technocentric perspectives dominate the PA discourse, although key themes seen in the wider literature on digital/data ethics are also evident. Risks and recommendations for PA projects concerned transparency and diverse stakeholder inclusion, respecting privacy rights, fair and proportionate use of data, fostering a systemic culture of ethical practice, delivering benefits for employees, including ethical outcomes in business models, ensuring legal compliance and using ethical charters. Research limitations/implications: This research adds to current debates over the future of work and employment in a digitized, algorithm-driven society. Practical implications: The research provides an accessible summary of the risks, opportunities, trade-offs and regulatory issues for PA, as well as a framework for integrating ethical strategies and practices. Originality/value: By using a scoping methodology to surface and analyze diverse literatures, this study fills a gap in existing knowledge on ethical aspects of PA. The findings can inform future academic research, organizations using or considering PA products, professional associations developing relevant guidelines and policymakers adapting regulations. It is also timely, given the increase in digital monitoring of employees working from home during the Covid-19 pandemic

The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation

Objective—The activation of nuclear factor-kB (NF-kB) is a crucial step in the arterial wall’s response to injury. The identification and characterization of the NF-kB essential modulator– binding domain (NBD) peptide, which can block the activation of the IkB kinase complex, have provided an opportunity to selectively abrogate the inflammation-induced activation of NF-kB. The aim of the present study was to evaluate the effect of the NBD peptide on neointimal formation.<br></br> Methods and Results—In the rat carotid artery balloon angioplasty model, local treatment with the NBD peptide (300 microg/site) significantly reduced the number of proliferating cells at day 7 (by 40%; P<0.01) and reduced injury-induced neointimal formation (by 50%; P<0.001) at day 14. These effects were associated with a significant reduction of NF-kB activation and monocyte chemotactic protein-1 expression in the carotid arteries of rats treated with the peptide. In addition, the NBD peptide (0.01 to 1 micromol/L) reduced rat smooth muscle cell proliferation, migration, and invasion in vitro. Similar results were observed in apolipoprotein E-/-, mice in which the NBD peptide (150 microg/site) reduced wire-induced neointimal formation at day 28 (by 47%; P<0.01).<br></br> Conclusion—The NBD peptide reduces neointimal formation and smooth muscle cell proliferation/migration, both effects associated with the inhibition of NF-kB activation

Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries

<p><b>Objective:</b> We have previously demonstrated that bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs), is effective in reducing neointimal formation in rodent models of vascular injury by reducing smooth muscle cell proliferation and migration and neointimal macrophage content, effects associated with the inhibition of MCP-1/CCL2 production. The aim of the current study was to evaluate the efficacy of bindarit on in-stent stenosis in the preclinical porcine coronary stent model.</p> <p><b>Methods and Results:</b> One or 2 bare metal stents (Multi-Link Vision, 3.5 mm) were deployed (1:1.2 oversize ratio) in the coronary arteries of 42 pigs (20 bindarit versus 22 controls). Bindarit (50 mg/kg per day) was administered orally from 2 days before stenting until the time of euthanasia at 7 and 28 days. Bindarit caused a significant reduction in neointimal area (39.4%, P<0.001, n=9 group), neointimal thickness (51%, P<0.001), stenosis area (37%, P<0.001), and inflammatory score (40%, P<0.001) compared with control animals, whereas there was no significant difference in the injury score between the 2 groups. Moreover, treatment with bindarit significantly reduced the number of proliferating cells (by 45%, P<0.05; n=6 group) and monocyte/macrophage content (by 55%, P<0.01; n=5–6 group) in stented arteries at day 7 and 28, respectively. These effects were associated with a significant (P<0.05) reduction of MCP-1 plasma levels at day 28. In vitro data showed that bindarit (10–300 micromol/L) reduced tumor necrosis factor-alpha (50 ng/mL)–induced pig coronary artery smooth muscle cell proliferation and inhibited MCP-1 production.</p> <p><b>Conclusion:</b> Our results show the efficacy of bindarit in the prevention of porcine in-stent stenosis and support further investigation for clinical application of this compound.</p&gt

Chiaroscuri d'autunno. Il danno non patrimoniale e le Sezioni Unite

L'A. condivide la decisione delle Sezioni Unite di negare l'esistenza del danno esistenziale, di superare la figura del danno morale soggettivo, di dar rilievo ai criteri della "gravità della lesione" e della "serietà del danno" e di ammettere il pieno ricorso alle valutazioni prognostiche e alla prova presuntiva. Non convincono, invece, la ricostruzione di una pretesa "tipicità" del sistema del danno non patrimoniale, fondata sul tentativo di far collimare la "tipicità" dei diritti inviolabili con una clausola generale "aperta" che li qualifica in termini di "atipicità" (art. 2 Cost.); la mancata considerazione della prospettiva dinamica del rapporto e del giudizio di comparazione tra gli interessi in conflitto; l'erroneo ricorso al giudizio d'ingiustizia per il danno non patrimoniale "da inadempimento"; la scelta di non considerare risarcibile il danno tanatologico e di riesumare, in sua vece, il danno esistenziale da sofferenza catastrofica; la "globalizzazione" del danno non patrimoniale che, non consentendo di distinguere tra danno biologico e danno morale, ingenera confusione tra i diversi sistemi di valutazione e di liquidazione; la mancata indicazione di qualsiasi standard per la quantificazione del "nuovo" danno morale. Per il danno "da reato" (ex art. 185 c.p.) permane l'originaria funzione punitiva della riparazione, voluta dai legislatori del 1930 e del 1942

Small bowel transplantation for diffuse intestinal angiomatosis

Intestinal angiomatosis is a very rare phenomenon producing lower gastrointestinal bleeding. Its most frequent causes are diverticula, congenital arteriovenous malformation, acquired angiodysplasia, ischemia, inflammation, ulceration, benign or malignant tumours and iatrogenic injury. In this paper, the case of a 48-year-old white man is reported

Prevalence of obesity and obesity-associated muscle wasting in patients on peritoneal dialysis

Background and aims: A progressive decrease in muscle mass until full-blown sarcopenia may occur in patients on peritoneal dialysis (PD) and worsen their life quality and expectancy. Here we investigate the prevalence of obesity and obesity-associated muscle wasting in PD patients. Patients and methods: The study design was observational, cross sectional. Body composition was assessed with BIA and BIVA in 88 PD patients (53.4 ± 13.1 years; 67% male). Patients with obesity and/or with reduced muscle mass were identified using FMI and SM/BW cutoff values, respectively. Inflammatory status was assessed by measuring CRP and fibrinogen blood levels. Results: A total of 44.3% of the patients showed a reduced muscle mass (37.5% moderate and 6.8% severe). The prevalence of obesity was 6.1%, 81.8%, and 100% in patients with normal, moderately, and severely reduced muscle mass, respectively (p < 0.05). Of the total, 15.2% of the patients with normal muscle mass, 18.4% of those with moderately reduced muscle mass, and 66.7% of those with severely reduced muscle mass had diabetes. The prevalence of severe muscle mass loss was higher in those with diabetes than in those without diabetes (22.2% vs. 2.8%, p < 0.05). Patients with obesity-associated muscle wasting showed higher fibrinogen (613.9 ± 155.1 vs. 512.9 ± 159.5 mg/dL, p < 0.05) and CPR (1.4 ± 1.3 vs. 0.6 ± 0.8 mg/dL, p < 0.05) blood concentrations than those with normal body composition. Conclusion: Obesity and diabetes were strongly associated with muscle mass loss in our PD patients. It remains to be established whether prevention of obesity with nutritional interventions can halt the occurrence of muscle mass loss in patients on PD

Speeding up TOMAWAC by means of improved numerical methods

Hydrodynamic

Effect of a moderately hypoenergetic Mediterranean diet and exercise program on body cell mass and cardiovascular risk factors in obese women

Objective: To assess the effects of a moderately hypoenergetic Mediterranean diet (MHMD) and exercise program on body cell mass (BCM) and cardiovascular disease risk factors in obese women. Subjects/Methods: Forty-seven obese women, 39.7 +/- 13.2 years of age, with a body mass index (BMI) 30.7 +/- 6.0 kg/m(2), completed the study. The following were measured at baseline, 2 and 4 months: BCM, BCM index (BCMI), body weight, BMI, fat-free mass (FFM), fat mass (FM), total body water (TBW), extracellular water (ECW) and intracellular water (ICW) using bioelectrical impedance analysis; fasting blood glucose (FBG), serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations; systolic (SBP) and diastolic (DBP) blood pressure. Results: Body weight, BMI, FM, TC and TG significantly decreased (P<0.001; P<0.002 (TG)) at 2 and 4 months. FFM, TBW, ECW, FBG and DBP significantly decreased at 2 months (P<0.05 (FFM); P<0.001). LDL-C significantly decreased (P<0.001), while HDL-C significantly increased (P<0.002) at 4 months. BCM, BCMI, ICW and SBP remained stable over time. Conclusion: BCM was preserved and cardiovascular disease risk factors improved in obese women placed on a MHMD and exercise program for 4 months