1 research outputs found
Π‘ΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΠΎΠ³ΠΎ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΡ ΠΈ Π°Π΄ΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΎΡΡΠ° Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠ°Π½
Growth factors (GFs) are endogenous signaling proteins, that regulate cell migration, proliferation and differentiation in tissue regeneration. GFsβ concentrations in chronic wounds are pathologically reduced. This leads to a disruption of the healing process and makes chronic wounds treatment more complicated. There are drugs currently used in clinical practice, that contain GFs in a free form. However, their efficiency for chronic wounds treatment is limited, as GFs are quickly degraded in a proteolytic environment of chronic wounds. In order to overcome this limitation biocompatible molecular systems for targeted delivery and controlled release are proposed, such as: micro- and nanoparticles, hydrogels, scaffolds. GFs roles in the healing process, chronic wounds pathophysiology and molecular systems for GFs targeted delivery and controlled release are reviewed.Π€Π°ΠΊΡΠΎΡΡ ΡΠΎΡΡΠ° (Π€Π ) β ΡΡΠΎ ΡΠ½Π΄ΠΎΠ³Π΅Π½Π½ΡΠ΅ ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΠ΅ Π±Π΅Π»ΠΊΠΈ, ΠΊΠΎΡΠΎΡΡΠ΅ ΡΠ΅Π³ΡΠ»ΠΈΡΡΡΡ ΠΌΠΈΠ³ΡΠ°ΡΠΈΡ, ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΡ ΠΈ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΡ ΠΊΠ»Π΅ΡΠΎΠΊ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ°Ρ
ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠΈ ΡΠΊΠ°Π½Π΅ΠΉ. ΠΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΡΡΠΈΡ
Π±Π΅Π»ΠΊΠΎΠ² Π² Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°Π½Π°Ρ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΠ½ΠΈΠΆΠ΅Π½Π°, ΡΡΠΎ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ°Π½Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ° ΠΈ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π·Π°ΡΡΡΠ΄Π½ΡΠ΅Ρ ΠΈΡ
Π»Π΅ΡΠ΅Π½ΠΈΠ΅. Π ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡΡΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Π½ΡΠ½ΡΠ΅ Π€Π Π² ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎΠΉ ΡΠΎΡΠΌΠ΅. ΠΠ΄Π½Π°ΠΊΠΎ ΠΈΡ
ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄Π»Ρ Π»Π΅ΡΠ΅Π½ΠΈΡ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°Π½ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π°, ΡΠ°ΠΊ ΠΊΠ°ΠΊ Π² ΠΏΡΠΎΡΠ΅ΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ΅Π΄Π΅ ΡΠ°ΠΊΠΈΡ
ΡΠ°Π½ Π€Π ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π°ΡΡΡΡ Π±ΡΡΡΡΠΎΠΉ Π΄Π΅Π³ΡΠ°Π΄Π°ΡΠΈΠΈ. ΠΠ»Ρ ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΈΡ ΡΡΠΎΠ³ΠΎ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠ° ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ Π°Π΄ΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΠΎΠ³ΠΎ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Π±ΠΈΠΎΡΠΎΠ²ΠΌΠ΅ΡΡΠΈΠΌΡΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ²: ΠΌΠΈΠΊΡΠΎ- ΠΈ Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡΡ, Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»ΠΈ, Π±ΠΈΠΎΠΏΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ. Π Π½Π°ΡΡΠΎΡΡΠ΅ΠΌ ΠΎΠ±Π·ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠΎΠ»ΠΈ Π€Π Π² ΡΠ°Π½Π΅Π²ΠΎΠΌ ΠΏΡΠΎΡΠ΅ΡΡΠ΅, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠ°ΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°Π½ ΠΈ ΡΠΈΡΡΠ΅ΠΌΡ Π΄Π»Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΠΎΠ³ΠΎ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π΅Π½ΠΈΡ ΠΈ Π°Π΄ΡΠ΅ΡΠ½ΠΎΠΉ Π΄ΠΎΡΡΠ°Π²ΠΊΠΈ Π€Π