Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).

We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35-1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24-5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09-4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09-1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services

UC Digital Preservation Strategy Working Group: Phase One Report

In the Fall of 2018, the Direction and Oversight Committee (DOC) formed the Digital Preservation Strategy (DPS) Working Group with the charge of (1) developing a practical, shared vision of digital preservation for library content, and (2) outlining a roadmap to guide the UC Libraries in advancing that shared vision. The DPS Working Group will fulfill this charge in multiple phases, and this report presents the results of Phase One, which lays the groundwork for further discussion and, ultimately, recommendations on the policies, strategies, and actions required for the digital preservation of the millions of digital assets held across the ten UC campuses and the California Digital Library. Specifically, the Phase One report focuses on three areas: (1) an overview of external digital preservation service providers (exemplar organizations), including consortia, vendors, and university-based providers; (2) background information on current and planned UC libraries’ digital preservation activities; and (3) a high-level overview of current best practices for digital preservation, based on the Open Archival Information System (OAIS) reference model

UC Digital Preservation Strategy Working Group: Phase One Report

In the Fall of 2018, the Direction and Oversight Committee (DOC) formed the Digital Preservation Strategy (DPS) Working Group with the charge of (1) developing a practical, shared vision of digital preservation for library content, and (2) outlining a roadmap to guide the UC Libraries in advancing that shared vision. The DPS Working Group will fulfill this charge in multiple phases, and this report presents the results of Phase One, which lays the groundwork for further discussion and, ultimately, recommendations on the policies, strategies, and actions required for the digital preservation of the millions of digital assets held across the ten UC campuses and the California Digital Library. Specifically, the Phase One report focuses on three areas: (1) an overview of external digital preservation service providers (exemplar organizations), including consortia, vendors, and university-based providers; (2) background information on current and planned UC libraries’ digital preservation activities; and (3) a high-level overview of current best practices for digital preservation, based on the Open Archival Information System (OAIS) reference model

Depression and Oral FTC/TDF Pre-exposure Prophylaxis (PrEP) Among Men and Transgender Women Who Have Sex With Men (MSM/TGW).

We conducted a longitudinal and cross-sectional analysis of depressive symptomology in iPrEx, a randomized, placebo-controlled trial of daily, oral FTC/TDF HIV pre-exposure prophylaxis (PrEP) in men and transgender women who have sex with men. Depression-related adverse events (AEs) were the most frequently reported severe or life-threatening AEs and were not associated with being randomized to the FTC/TDF arm (152 vs. 144 respectively OR 0.66 95 % CI 0.35-1.25). Center for Epidemiologic Studies Depression scale (CES-D) and a four questions suicidal ideation scale scores did not differ by arm. Participants reporting forced sex at anal sexual debut had higher CES-D scores (coeff: 3.23; 95 % CI 1.24-5.23) and were more likely to have suicidal ideation (OR 2.2; 95 % CI 1.09-4.26). CES-D scores were higher among people reporting non-condom receptive anal intercourse (ncRAI) (OR 1.46; 95 % CI 1.09-1.94). We recommend continuing PrEP during periods of depression in conjunction with provision of mental health services

Analyse und Optimierung fluidisch und mechanisch gekoppelter grossvolumiger meerestechnischer Mehrkoerpersysteme bei instationaerer Wellenbelastung Schlussbericht

For hydrodynamic analyses of offshore-multibody systems an exact sea wave-structure interaction theory taking into account the water compressibility has been developed, which is based on the calculation of diffraction matrices of the single bodies. Hydrodynamic analyses of the single bodies were carried out using the Trofftz method for fitting boundary conditions. Biorthogonal functional series were applied for computation of earthquake induced hydrodynamic pressures at rotationally symmetrical offshore buildings of the monotower type and of submarine oil reservoirs. Experimental investigations for evaluation of the calculation methods have been started in a slack water basin. (WEN)SIGLEAvailable from TIB Hannover: F95B1686 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekStiftung Volkswagenwerk, Hannover (Germany)DEGerman

Alpha emitter radium-223 and survival in metastatic prostate cancer

BACKGROUND: Radium-223 dichloride (radium-223), an alpha emitter, selectively targets bone metastases with alpha particles. We assessed the efficacy and safety of radium-223 as compared with placebo, in addition to the best standard of care, in men with castration-resistant prostate cancer and bone metastases. METHODS: In our phase 3, randomized, double-blind, placebo-controlled study, we randomly assigned 921 patients who had received, were not eligible to receive, or declined docetaxel, in a 2:1 ratio, to receive six injections of radium-223 (at a dose of 50 kBq per kilogram of body weight intravenously) or matching placebo; one injection was administered every 4 weeks. In addition, all patients received the best standard of care. The primary end point was overall survival. The main secondary efficacy end points included time to the first symptomatic skeletal event and various biochemical end points. A prespecified interim analysis, conducted when 314 deaths had occurred, assessed the effect of radium-223 versus placebo on survival. An updated analysis, when 528 deaths had occurred, was performed before crossover from placebo to radium-223. RESULTS: At the interim analysis, which involved 809 patients, radium-223, as compared with placebo, significantly improved overall survival (median, 14.0 months vs. 11.2 months; hazard ratio, 0.70; 95% confidence interval [CI], 0.55 to 0.88; two-sided P=0.002). The updated analysis involving 921 patients confirmed the radium-223 survival benefit (median, 14.9 months vs. 11.3 months; hazard ratio, 0.70; 95% CI, 0.58 to 0.83; P<0.001). Assessments of all main secondary efficacy end points also showed a benefit of radium-233 as compared with placebo. Radium-223 was associated with low myelosuppression rates and fewer adverse events. CONCLUSIONS: In this study, which was terminated for efficacy at the prespecified interim analysis, radium-223 improved overall survival. (Funded by Algeta and Bayer HealthCare Pharmaceuticals; ALSYMPCA ClinicalTrials.gov number, NCT00699751.)