FINANCIAL ANALYSIS OF PHARMACEUTICAL COMPANIES

In the article the observed factors affecting the production of medicines, as well as indicate what documents regulating the activities of these enterprises. Identified the stages of financial analysis of pharmaceutical companies, described in detail techniques of financial analysis in pharmaceutical institutions and economic indicators that characterize all the economic activities of the pharmaceutical network

MODERN UNDERSTANDING OF ASSESMENT THE FINANCIAL CONDITION OF THE COMPANY: SUBJECT, OBJECTIVES, APPROACHES

In the article the methodological approaches of different authors to the definition of financial analysis and assessment of the financial condition of the company. It noted the objectives and subject the financial condition of the company. The basic stages of development of financial analysis and describes the main challenges for the analysis at this stage

MODERN UNDERSTANDING OF ASSESMENT THE FINANCIAL CONDITION OF THE COMPANY: SUBJECT, OBJECTIVES, APPROACHES

In the article the methodological approaches of different authors to the definition of financial analysis and assessment of the financial condition of the company. It noted the objectives and subject the financial condition of the company. The basic stages of development of financial analysis and describes the main challenges for the analysis at this stage

FINANCIAL ANALYSIS OF PHARMACEUTICAL COMPANIES

In the article the observed factors affecting the production of medicines, as well as indicate what documents regulating the activities of these enterprises. Identified the stages of financial analysis of pharmaceutical companies, described in detail techniques of financial analysis in pharmaceutical institutions and economic indicators that characterize all the economic activities of the pharmaceutical network

Machine learning and Deep Learning Methods of Microorganisms' Segmentation Survey

This survey is aimed to release different methods of biological image segmentation via computer processing and compare their efficiency

CHEST X-RAY RIBS AND CLAVICLES SUPPRESSION VIA MACHINE LEARNING METHODS

The existence of structures such as ribs and clavicles in chest X-ray images can cover subtle findings. The purpose of this study is to build a machine learning based bone suppression model that recognizes and removes occluding structures in frontal chest radiograms reducing diagnostic errors

SEGMENTATION OF MICROORGANISMS IN GORIAEV'S CAMERA USING RANDOM FOREST AND XGBOOST ALGORITHMS

This project is aimed to consider a way of solving a problem of counting the microorgan-isms in the Goriaev's camera based on machine learning algorithms

Состояние и динамика первичной и повторной инвалидности вследствие глаукомы взрослого населения Алтайского края

PURPOSE: the study of the dynamics of primary and repeated disability due to glaucoma in the adult population of the Altai Territory for the 2004-2013 period. METHODS: We analyzed the data provided by the Central Bureau of Medical and Social Expertise of the Altai Territory over the 2004-2013 period. The analysis was conducted for three age groups of the adult population according to the criteria of the №7-social security form. RESULTS: Among the causes of primary and repeated disability in adults in the Altai region the class of eye and adnexa diseases held the 9-10th ranking places. Glaucoma consistently ranked first in the nosological structure of primary disability (PD) due to eye diseases. In case of repeated disability (RD) within the analyzed time span glaucoma moved from the third to the first place, thus increasing its share in causes of repeated disability due to diseases of the eye and adnexa by a factor of 2.1. The population of primarily disabled due to glaucoma was equally formed by male and female patients, from both urban and rural population, mostly presented by elderly patients with I and II disability groups. The III disability group prevailed among young and middle-aged patients. The contingent of repeatedly disabled due to glaucoma was formed mainly by the elderly patients of I and II disability groups, coming equally from the urban and rural population, with twice as many men as women. CONCLUSION: The specifics of primary and repeated disability due to the diseases of the eye and adnexa over a 10-year period were defined. Glaucoma ranked first in both groups. The intensive index of primary disability due to glaucoma increased from 0.7 per 10 000 of the adult population in 2004 to 1.1 in 2005 (by 57%) with a further decrease to 0.4 by 2013 (by 63.6%). The level of repeated disability due to glaucoma increased from 0.6 per 10,000 adult population in 2004 to 0.9 in 2012-2013 (by 50%).ЦЕЛЬ. Изучение динамики первичной и повторной инвалидности вследствие глаукомы среди взрослого населения Алтайского края за период с 2004 по 2013 гг. МЕТОДЫ. Нами проанализированы данные ФКУ «Главного бюро медико-социальной экспертизы по Алтайскому краю» в динамике за 2004-2013 гг. Анализ проведен по трем возрастным группам взрослого населения в соответствии с критериями формы № 7-собес. РЕЗУЛЬТАТЫ. Среди причин первичной и повторной инвалидности у взрослых в Алтайском крае класс «болезни глаза и его придаточного аппарата» занимал 9-10 ранговые места. В нозологической структуре впервые признанных инвалидами (ВПИ) вследствие болезней глаза глаукома за анализируемый период стабильно занимала первое ранговое место, среди повторно признанных инвалидами (ППИ) глаукома с третьего рангового места поднялась на первое, и ее доля в структуре повторной инвалидности вследствие болезней глаза и его придаточного аппарата увеличилась в 2,1 раза. Контингент ВПИ вследствие глаукомы формировался лицами в равной степени мужского и женского пола, а также городского и сельского населения, пенсионного возраста с I и II группами инвалидности, среди лиц молодого и среднего возраста преобладала III группа инвалидности. Контингент ППИ вследствие глаукомы формировался лицами пенсионного возраста, лица мужского пола в 2 раза превалировали над лицами женского пола, представлены I и II группы инвалидности, в равной степени среди городского и сельского населения. ЗАКЛЮЧЕНИЕ. Определены особенности первичной и повторной инвалидности вследствие болезней глаза и его придаточного аппарата в динамике за 10 лет: первое ранговое место занимает глаукома. Интенсивный показатель первичной инвалидности вследствие глаукомы возрастал с 0,7 на 10 000 взрослого населения в 2004 г. до 1,1 в 2005 г. (на 57%) с дальнейшим снижением до 0,4 в 2013 г. (на 63,6%). Уровень повторной инвалидности вследствие глаукомы возрастал с 0,6 на 10 000 взрослого населения в 2004 г. до 0,9 в 2012-2013 гг. (на 50%)

Automation of the main processes of the medical organization on the basis of the applied solution "1C: Medicine. Polyclinic"

В диссертации был проведен анализ литературы и нормативно-справочной документации по теме диссертации, по результатам исследования была сформирована таблица сравнений медицинских информационных систем. Разработаны требования к медицинским системам. В ходе работы были построены модели исследуемых бизнес-процессов и разработан новый блок медицинской информационной системы для клиники «Геном-Волга».The analysis of literature and normative-reference documentation on the subject of the thesis was carried out in the thesis, the table of comparisons of medical information systems was formed based on the results of the research. Requirements to medical systems are developed. In the course of the work, models of the studied business processes were built and a new block of medical information system for Genom-Volga clinic was developed

<i>tert</i>-Butyl (<i>E</i>)-3-oxo-2-(3-oxoisobenzofuran-1(3<i>H</i>)-ylidene)butanoate

Non-fullerene acceptors have recently attracted much attention as components of organic solar cells. 1H-indene-1,3(2H)-dione is a key compound for the synthesis of the end-capping component of non-fullerene acceptors. In this communication, an intermediate for the synthesis of this compound, tert-butyl (E)-3-oxo-2-(3-oxoisobenzofuran-1(3H)-ylidene)butanoate, was prepared by the reaction between phthalic anhydride and tert-butyl acetoacetate. Further treatment with sodium methoxide in methanol led to the formation of 1H-indene-1,3(2H)-dione in a high yield. The structure of the newly synthesized compound was established by means of elemental analysis, high-resolution mass spectrometry, 1H, 13C NMR, IR spectroscopy, mass spectrometry and X-ray analysis