Activity of eribulin mesylate in brain metastasis from breast cancer. a stone in a pond?

Background: Brain metastases develop in approximately 10-25% of patients with metastatic breast cancer (MBC) and are associated with a very poor prognosis. Case Report: We report the case of a 40-year-old woman with MBC and associated lung, bone, liver, and brain metastases, who experienced a time to progression of several months with eribulin after whole-brain radiotherapy (WBRT), 2 lines of chemotherapy, and 1 line of hormonal therapy, maintaining a good toxicity profile. Discussion: Eribulin, in association with local treatment such as WBRT, can be well tolerated and effective in achieving a long progression-free survival and a good control of brain metastases in patients with MBC who have received multiple lines of treatment. The vascular remodeling properties of eribulin, combined with brain radiotherapy, might facilitate the passage of eribulin across the blood brain barrier, improving brain response. Conclusion: Our anecdotal experience suggests that eribulin may have a potentially beneficial effect on brain metastases while maintaining a good systemic control of the disease in patients with MBC

Thermal Noise-Boosting Effects in Hot-Wire-Based Micro Sensors

This article proposes an original approach aimed at modelling the noise density in sensors based on a single hot wire or pairs of thermally coupled wires. The model consists in an original combination of a previous electrothermal model of the wire with well-established assumptions on the thermal noise in conductors that carry moderate current densities. A simple method for estimating the model parameters with simple impedance spectroscopy is suggested. The predicted power spectral densities of the wire thermal noise differ from the result of previously presented analytical models, stimulating further experimental studies. The effects of the electrothermal feedback of both hot wires and hot-wire pairs on flicker noise is also intrinsically covered by the proposed approach

A Logical Approach to Cooperative Information Systems

``Cooperative information system management'' refers to the capacity of several computing systems to communicate and cooperate in order to acquire, store, manage, query data and knowledge. Current solutions to the problem of cooperative information management are still far from being satisfactory. In particular, they lack the ability to fully model cooperation among heterogeneous systems according to a declarative style. The use of a logical approach to model all aspects of cooperation seems very promising. In this paper, we de®ne a logical language able to support cooperative queries, updates and update propagation. We model the sources of information as deductive databases, sharing the same logical language to ex- press queries and updates, but containing independent, even if possibly related, data. We use the Obj-U-Datalog (E. Bertino, G. Guerrini, D. Montesi, Toward deductive object data- bases, Theory and Practice of Object Systems 1 (1) (1995) 19±39) language to model queries and transactions in each source of data. Such language is then extended to deal with active rules in the style of Active-U-Datalog (E. Bertino, B. Catania, V. Gervasi, A. Ra aet a, Ac- tive-U-Datalog: Integrating active rules in a logical update language, in: B. Freitag, H. Decker, M. Kifer, A. Voronkov (Eds.), LBCS 1472: Transactions and Change in Login Databases, 1998, pp. 106±132), interpreted according to the PARK semantics proposed in G. Gottlob, G. Moerkotte, V.S. Subrahmanian (The PARK semantics for active rules, in: P.M.G. Apers, M. Bouzeghoub, G. Gardarin (Eds.), LNCS 1057: Proceedings of the Fifth International Con- ference on Extending Database Technology, 1996, pp. 35±55). By using active rules, a system can e ciently perform update propagation among di erent databases. The result is a logical environment, integrating active and deductive rules, to perform update propagation in a cooperative framework

Early Minimally Invasive Percutaneous Fixation of Displaced Intra-Articular Calcaneal Fractures With a Percutaneous Angle Stable Device.

The Minimally Invasive Reduction and Osteosynthesis System(®) (MIROS) is a percutaneous angle stable device for the treatment of fractures. The aim of the present study was to evaluate the clinical and radiographic results of an early minimally invasive osteosynthesis with the MIROS device. A total of 40 consecutive patients were treated for an intra-articular fracture of the calcaneus. We evaluated the clinical and radiographic outcomes after treatment of intra-articular calcaneal fractures with the MIROS hardware. Soft tissue damage was noted. The patients completed the American Orthopaedic Foot and Ankle Society survey at 12 and 24 months and underwent radiologic evaluations. A statistically significant association between the American Orthopaedic Foot and Ankle Society score and type of soft tissue lesion. A Sanders type II, III, and IV fracture was found in 15, 20, and 15 of 50 fractures, respectively. Postoperatively, restoration of the posterior facet was reached in 13 of 15, 18 of 20, and 11 of 15 with a type II, III, and IV fracture, respectively. The American Orthopaedic Foot and Ankle Society scale mean score was 85 at the final follow-up visit. No significant association was found between the score and the preoperative variables (p > .09), although patients with bilateral fractures had a significantly lower score. The MIROS device for early treatment of intra-articular calcaneus fractures resulted in excellent clinic and radiologic results. The standardized technique we have reported, with the elastic wires acting as a girder for the fractured and displace subtalar joint and the collapsed lateral calcaneal wall, has permitted early weightbearing with positive stimuli for the bone healing. The drainage effect of the percutaneous wires likely prevented compartment syndrome when applied within the first hours after the trauma.The Minimally Invasive Reduction and Osteosynthesis System® (MIROS) is a percutaneous angle stable device for the treatment of fractures. The aim of the present study was to evaluate the clinical and radiographic results of an early minimally invasive osteosynthesis with the MIROS device. A total of 40 consecutive patients were treated for an intra-articular fracture of the calcaneus. We evaluated the clinical and radiographic outcomes after treatment of intra-articular calcaneal fractures with the MIROS hardware. Soft tissue damage was noted. The patients completed the American Orthopaedic Foot and Ankle Society survey at 12 and 24 months and underwent radiologic evaluations. A statistically significant association between the American Orthopaedic Foot and Ankle Society score and type of soft tissue lesion. A Sanders type II, III, and IV fracture was found in 15, 20, and 15 of 50 fractures, respectively. Postoperatively, restoration of the posterior facet was reached in 13 of 15, 18

A two-stage switched-capacitor integrator for high gain inverter-like architectures

A discrete-time, switched capacitor integrator is presented. The integrator is based on a two-stage architecture where the first stage converts the input voltage into a charge that is accumulated into the second stage. The main strength of the proposed circuit is a higher dc gain with respect to previous solutions, making it optimal for low-voltage inverter-like integrators. A further advantage is the fact that, in contrast with existing solutions, the output voltage is valid across the whole clock cycle. Theoretical analysis of the circuit is performed to calculate the dependence of the integrator dc gain and input-referred offset voltage on the corresponding parameters of the constituting amplifiers. Discrete-time simulations are performed to estimate the gain and phase error with respect to an ideal integrator. The results of electrical simulations performed on an inverter-like prototype, designed with the UMC 0.18-μm CMOS process, are presented to show the impact of non-idealities from the amplifiers and switches