63 research outputs found
Oxaliplatin-DNA adduct formation in white blood cells of cancer patients
In this study, we investigated the kinetics of oxaliplatin-DNA adduct formation in white blood cells of cancer patients in relation to efficacy as well as oxaliplatin-associated neurotoxicity. Thirty-seven patients with various solid tumours received 130âmgâmâ2 oxaliplatin as a 2-h infusion. Oxaliplatin-DNA adduct levels were measured in the first cycle using adsorptive stripping voltammetry. Platinum concentrations were measured in ultrafiltrate and plasma using a validated flameless atomic absorption spectrometry method. DNA adduct levels showed a characteristic time course, but were not correlated to platinum pharmacokinetics and varied considerably among individuals. In patients showing tumour response, adduct levels after 24 and 48âh were significantly higher than in nonresponders. Oxaliplatin-induced neurotoxicity was more pronounced but was not significantly different in patients with high adduct levels. The potential of oxaliplatin-DNA adduct measurements as pharmacodynamic end point should be further investigated in future trials
Neuer Echtzeitkern zur Verbesserung von Dynamik und Sicherheit eines navigierten Chirurgie-Assistenzroboters A Novel Real Time Core for Dynamics and Safety Enhancement of a Navigated Surgical Assistance Robot
Exceptional catalytic performance of AuâPt/Îł-Al2O3 in naphtha reforming at very low Au dosing levels
Influence of Time and Temperature on the Regeneration of PtReIn/Al2O3 Naphtha Reforming Catalysts
Roles of Pt and alumina during the combustion of coke deposits on propane dehydrogenation catalysts
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