Deep learning prediction of proton and photon dose distributions for paediatric abdominal tumours

OBJECTIVE: Dose prediction using deep-learning networks prior to radiotherapy might lead to more efficient modality selections. The study goal was to predict proton and photon dose distributions based on the patient-specific anatomy and to assess their clinical usage for paediatric abdominal tumours. MATERIAL &METHODS: Data from 80 patients with neuroblastoma or Wilms' tumour was included. Pencil beam scanning (PBS) (5mm/3%) and volumetric-modulated arc therapy (VMAT) plans (5mm) were robustly optimized on the internal target volume (ITV). Separate 3-dimensional patch-based U-net networks were trained to predict PBS and VMAT dose distributions. Doses, planning-computed tomography images and relevant optimization masks (ITV, vertebra and organs-at-risk) of 60 patients were used for training with a 5-fold cross validation. The networks' performance was evaluated by computing the relative error between planned and predicted dose-volume histogram (DVH) parameters for 20 inference patients. In addition, the organs-at-risk mean dose difference between modalities was calculated using planned and predicted dose distributions (ΔDmean= DVMAT-DPBS). Two radiation oncologists performed a blind PBS/VMAT modality selection based on either planned or predicted ΔDmean. RESULTS: Average DVH differences between planned and predicted dose distributions were ≤|6%|for both modalities. The networks classified the organs-at-risk difference as a gain (ΔDmean>0) with 98% precision. An identical modality selection based on planned compared to predicted ΔDmean was made for 18/20 patients. CONCLUSION: Deep-learning networks for accurate prediction of proton and photon dose distributions for abdominal paediatric tumours were established. These networks allowing fast dose visualization might aid in identifying the optimal radiotherapy technique when experience and/or resources are unavailable

One-neutron knockout in the vicinity of the N=32 sub-shell closure: 9Be(57Cr,56Cr+ gamma)X

The one-neutron knockout reaction 9Be(57Cr,56Cr + gamma)X has been measured in inverse kinematics with an intermediate-energy beam. Cross sections to individual states in 56Cr were partially untangled through the detection of the characteristic gamma-ray transitions in coincidence with the reaction residues. The experimental inclusive longitudinal momentum distribution and the yields to individual states are compared to calculations that combine spectroscopic factors from the full fp shell model and nucleon-removal cross sections computed in a few-body eikonal approach.Comment: PRC, in pres

Spectroscopy of the odd-odd fp-shell nucleus 52Sc from secondary fragmentation

The odd-odd fp-shell nucleus 52Sc was investigated using in-beam gamma-ray spectroscopy following secondary fragmentation of a 55V and 57Cr cocktail beam. Aside from the known gamma-ray transition at 674(5)keV, a new decay at E_gamma=212(3) keV was observed. It is attributed to the depopulation of a low-lying excited level. This new state is discussed in the framework of shell-model calculations with the GXPF1, GXPF1A, and KB3G effective interactions. These calculations are found to be fairly robust for the low-lying level scheme of 52Sc irrespective of the choice of the effective interaction. In addition, the frequency of spin values predicted by the shell model is successfully modeled by a spin distribution formulated in a statistical approach with an empirical, energy-independent spin-cutoff parameter.Comment: accepted for publication in PR

Spectroscopy of 194^{194}Po

Prompt, in-beam $\gamma$ rays following the reaction $^{170}$Yb + 142 MeV $^{28}$Si were measured at the ATLAS facility using 10 Compton-suppressed Ge detectors and the Fragment Mass Analyzer. Transitions in $^{194}$Po were identified and placed using $\gamma$-ray singles and coincidence data gated on the mass of the evaporation residues. A level spectrum up to J$\approx$10$\hbar$ was established. The structure of $^{194}$Po is more collective than that observed in the heavier polonium isotopes and indicates that the structure has started to evolve towards the more collective nature expected for deformed nuclei.Comment: 8 pages, revtex 3.0, 4 figs. available upon reques

Half-life and spin of 60Mn^g

A value of 0.28 +/- 0.02 s has been deduced for the half-life of the ground state of 60Mn, in sharp contrast to the previously adopted value of 51 +/- 6 s. Access to the low-spin 60Mn ground state was accomplished via beta decay of the 0+ 60Cr parent nuclide. New, low-energy states in 60Mn have been identified from beta-delayed gamma-ray spectroscopy. The new, shorter half-life of 60Mn^g is not suggestive of isospin forbidden beta decay, and new spin and parity assignments of 1+ and 4+ have been adopted for the ground and isomeric beta-decaying states, respectively, of 60Mn.Comment: 13 pages, 5 figures, Accepted for publication in Phys. Rev.

Cross-shell excitation in two-proton knockout: Structure of 52^{52}Ca

The two-proton knockout reaction $^9$Be($^{54}$Ti,$^{52}$Ca$+ \gamma$) has been studied at 72 MeV/nucleon. Besides the strong feeding of the $^{52}$Ca ground state, the only other sizeable cross section proceeds to a 3$^-$ level at 3.9 MeV. There is no measurable direct yield to the first excited 2$^+$ state at 2.6 MeV. The results illustrate the potential of such direct reactions for exploring cross-shell proton excitations in neutron-rich nuclei and confirms the doubly-magic nature of $^{52}$Ca

Variation with mass of \boldmath{B(E3; 0_1^+ \to 3_1^-)} transition rates in A=124−134A=124-134 even-mass xenon nuclei

$B(E3; 0_1^+ \to 3_1^-)$ transition matrix elements have been measured for even-mass $^{124-134}$Xe nuclei using sub-barrier Coulomb excitation in inverse kinematics. The trends in energy $E(3^-)$ and $B(E3; 0_1^+ \to 3_1^-)$ excitation strengths are well reproduced using phenomenological models based on a strong coupling picture with a soft quadrupole mode and an increasing occupation of the intruder $h_{11/2}$ orbital.Comment: 5 pages, 4 figures, PRC in pres

Electronic structure of triangular, hexagonal and round graphene flakes near the Fermi level

The electronic shell structure of triangular, hexagonal and round graphene quantum dots (flakes) near the Fermi level has been studied using a tight-binding method. The results show that close to the Fermi level the shell structure of a triangular flake is that of free massless particles, and that triangles with an armchair edge show an additional sequence of levels ("ghost states"). These levels result from the graphene band structure and the plane wave solution of the wave equation, and they are absent for triangles with an zigzag edge. All zigzag triangles exhibit a prominent edge state at the Fermi level, and few low-energy conduction electron states occur both in triangular and hexagonal flakes due to symmetry reasons. Armchair triangles can be used as building blocks for other types of flakes that support the ghost states. Edge roughness has only a small effect on the level structure of the triangular flakes, but the effect is considerably enhanced in the other types of flakes. In round flakes, the states near the Fermi level depend strongly on the flake radius, and they are always localized on the zigzag parts of the edge