70,975 research outputs found
Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration. In addition to homooligomeric complexes, Mfn2 also associates with Mfn1, but the functional significance of such heterooligomeric complexes is unknown. Also unknown is why Mfn2 mutations in CMT2A lead to cell type–specific defects given the widespread expression of Mfn2. In this study, we show that homooligomeric complexes formed by many Mfn2 disease mutants are nonfunctional for mitochondrial fusion. However, wild-type Mfn1 complements mutant Mfn2 through the formation of heterooligomeric complexes, including complexes that form in trans between mitochondria. Wild-type Mfn2 cannot complement the disease alleles. Our results highlight the functional importance of Mfn1–Mfn2 heterooligomeric complexes and the close interplay between the two mitofusins in the control of mitochondrial fusion. Furthermore, they suggest that tissues with low Mfn1 expression are vulnerable in CMT2A and that methods to increase Mfn1 expression in the peripheral nervous system would benefit CMT2A patients
Fluctuations and universality in a catalysis model with long-range reactivity
The critical properties of the Ziff-Gulari-Barshad (ZGB) model with the
addition of long-range reactivity [C.H. Chan and P.A. Rikvold, Phys. Rev. E 91,
012103 (2015)] are further investigated. The scaling behaviors of the order
parameter, susceptibility, and correlation length provide addi- tional evidence
that the universality class of the ZGB system changes from the two-dimensional
Ising class to the mean-field class with the addition of even a weak long-range
reactivity mechanism
Instability of three dimensional conformally dressed black hole
The three dimensional black hole solution of Einstein equations with negative
cosmological constant coupled to a conformal scalar field is proved to be
unstable against linear circularly symmetric perturbations.Comment: 5 pages, REVTe
Transformation media that rotate electromagnetic fields
We suggest a way to manipulate electromagnetic wave by introducing a rotation
mapping of coordinates that can be realized by a specific transformation of
permittivity and permeability of a shell surrounding an enclosed domain. Inside
the enclosed domain, the information from outside will appear as if it comes
from a different angle. Numerical simulations were performed to illustrate
these properties.Comment: 5 pages, 3 figure
Electric field induced charge noise in doped silicon: ionization of phosphorus donors
We report low frequency charge noise measurement on silicon substrates with
different phosphorus doping densities. The measurements are performed with
aluminum single electron transistors (SETs) at millikelvin temperatures where
the substrates are in the insulating regime. By measuring the SET Coulomb
oscillations, we find a gate voltage dependent charge noise on the more heavily
doped substrate. This charge noise, which is seen to have a 1/f spectrum, is
attributed to the electric field induced tunneling of electrons from their
phosphorus donor potentials.Comment: 4 page, 3 figure
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