How Industry 4.0 and Lean Management Are Interrelated with Green Paradigm

Recently, sustainability has been tackled several times due to the impending climate change the earth is facing. Numerous techniques have been applied to reverse the direction companies were going into. In this paper, it is explained the importance that Lean Manufacturing tools and Industry 4.0 technologies can have on the sustainable side of a company. The aim of this work is to fill the scientific gap related to studies deepening the combination of these different paradigms, Industry 4.0-Lean-Green, which have been scarcely investigated together. Thus, a Systematic Literature Review has been performed to detect which were the key variables of these three fields and then, it was studied what their interaction was. This study is giving the opportunity to understand the main variables of Industry 4.0 and Lean manufacturing on which companies have to act in order to have an impact on green variables and their overall sustainability

Investigating the influence of lean manufacturing approach on environmental performance: A systematic literature review

The growing emphasis on environmental sustainability has drawn considerable attention from both academia and industry practitioners. Factors such as escalating energy costs, heightened environmental degradation, and a burgeoning market demand for eco-friendly practices have compelled businesses to reassess their strategies through a green lens. Given that Lean principles are rooted in optimising operations to minimise waste across design and production processes, their synergy with the green paradigm is evident. However, despite the intuitive connection between Lean methodologies and environmental sustainability, the scholarly exploration of their impact remains largely underdeveloped. This research seeks to bridge this gap by conducting a comprehensive systematic literature review to dissect the current understanding of Lean manufacturing practices and their influence on environmental sustainability performance. The selected papers were meticulously screened and grouped into three clusters using the PRISMA diagram methodology. The primary objective was to discern the tangible effects of Lean practices on eco-efficiency performance and explore integrating Lean manufacturing principles with broader sustainable manufacturing approaches. A structured matrix was created to categorise and visualise the identified impacts gleaned from the initial articles. Nevertheless, the review revealed significant gaps in understanding, particularly regarding the factors that shape the efficacy of Lean manufacturing tools in enhancing eco-efficiency performance. The findings underscore the need for further research to unravel these complexities and delineate the mechanisms through which Lean practices contribute to environmental sustainability. Several avenues for future research have been delineated, focusing on how Lean manufacturing practices can be leveraged to support eco-efficiency performance effectively. While the preliminary findings shed light on the promising intersection between Lean principles and environmental sustainability, they also underscore the imperative for continued scholarly inquiry to unlock the full potential of Lean methodologies in fostering a greener industrial landscape

Ectonucleoside triphosphate diphosphohydrolase-1/CD39 affects the response to ADP of female rat platelets

There is evidence that an imbalance of extracellular purine levels may be associated with increased cardiovascular risk. Platelets play a pivotal role in vascular homeostasis and thrombosis and are important source of purine nucleotides and nucleosides. Hydrolysis of nucleotides ATP and ADP is regulated by two ectonucleotidases, triphosphate diphosphohydrolase-1 (NTPDase-1/CD39) and ecto-5’-nucleotidase (ecto-5’-NT/CD73). CD39 enzyme is expressed on the endothelium, circulating blood cells, and smooth muscle cells; there is evidence that changes in CD39 expression and activity affects the potential thrombogenic of a tissue. Gender difference in the cardiovascular risk has been extensively observed; however, while the age-dependent difference in the prevalence of cardiovascular events between men and women has been attributed to the loss of the protective effect of estrogens in the postmenopausal period, the physiological mechanism behind gender disparity is still unclear. Here, we evaluated comparatively male and female rat platelet reactivity and considered the possible role of CD39 at the basis of difference observed. We found a reduced in vitro response to ADP (1–30 µM) of female compared to male platelets, associated to increased platelet CD39 expression and activity. Platelet response to ADP was strongly increased by incubation (10 min) with the CD39 inhibitor, ARL67156 (100 µM), while male platelet response was unaffected. Rat treatment with clopidogrel (30 mg/kg, per os) inhibited ex vivo platelet aggregation. Bleeding time was prolonged in female compared to male. Taken together, our results suggest that platelet ATPase and ADPase activity might be a reliable predictor of platelet reactivity

Exploring the Adoption of UX-Driven Approaches to Design Industrial PLC User Interfaces

Modern automated production systems (e.g., automatic machines, assembly lines, robotic cells) are typically governed by dedicated industrial controllers, such as Programmable Logic Controllers (PLCs), which supervise and coordinate the process by exchanging I/O data, sequencing tasks or triggering actions with the involved automation modules. Different solutions have been developed to offer an intuitive Human-Machine Interface (HMI) programming to the user, based on PLC HMI editors, according to vendor-specific programming languages. However, in the current industrial practice, user interfaces (UIs) are usually generated by software specialists and far from adopting any user-centered approach. As a result, the generated UIs are poorly usable and hard to understand for end users (e.g., operators), diverging from Industry 5.0 ideas that put humans at the center of the modern factory design. In this context, the present paper aims at exploring how the adoption of User eXperience (UX) driven approaches can benefit the design of industrial PLC UIs, reflecting on advantages and limits, and transdisciplinary perspectives. A case study utilizing Beckhoff TwinCAT as PLC environment and Adobe XD as UX design tool is examined and discussed

Online motion accuracy compensation of industrial servomechanisms using machine learning approaches

This paper addresses the crucial aspect of position error modeling and compensation in industrial servomechanisms with the aim to achieve accurate control and high-performance operation in industrial robots and automated production systems. The inherent complexity and nonlinear behavior of these modules, usually consisting of a servomotor and a speed reducer, often challenge traditional analytical modeling approaches. In response, the study extensively explores the design and implementation of Machine Learning (ML) algorithms to obtain a comprehensive model of the Transmission Error (TE) in rotating vector reducers, which is a main source of robot motion accuracy errors. The ML models are trained with experimental data obtained from a special purpose test rig, where the reducer is tested under different combinations of input speed, applied load and oil temperature. In the second part of the work, the resulting predictive model, tailored to capture the intricate dynamics of the analyzed reducer, is imported into a programmable logic controller to enable online compensation strategies during the execution of custom motion profiles. Experimental tests are conducted using two distinct motion profiles: one generated with a cycloidal law, typical of industrial machinery, and the other extrapolated from the joints of an industrial robot during a pick-and-place task. The results demonstrate the effectiveness of the proposed approach, enabling accurate prediction and substantial reductions (over 90%) in the overall reducer TE through the implemented predictive model

A literature review on surgery for cervical vagal schwannomas

Cervical vagal schwannoma is a benign, slow-growing mass, often asymptomatic, with a very low lifetime risk of malignant transformation in general population, but diagnosis is still a challenge. Surgical resection is the treatment of choice even if its close relationship with nerve fibres, from which it arises, threats vagal nerve preservation. We present a case report and a systematic review of literature. All studies on surgical resection of cervical vagal schwannoma have been reviewed. Papers matching the inclusion criteria (topic on surgical removal of cervical vagal schwannoma, English language, full text available) were selected. Fifty-three patients with vagal neck schwannoma submitted to surgery were identified among 22 studies selected. Female/male ratio was 1.5 and median age 44 years. Median diameter was 5 cm (range 2 to 10). Most schwannoma were asymptomatic (68.2%) and received an intracapsular excision (64.9%). Postoperative symptoms were reported in 22.6% of patients. Cervical vagal schwannoma is a benign pathology requiring surgical excision, but frequently postoperative complications can affect patients lifelong, so, surgical indications should be based carefully on the balance between risks and benefits

Carboplatin plus paclitaxel in extensive small cell lung cancer: a multicentre phase 2 study

A multicentre phase 2 trial (single-stage design) was undertaken to test the efficacy and toxicity of carboplatin (AUC 6 according to Calvert) plus paclitaxel (175 mg/m23-h infusion) every 4 weeks in the first line treatment of patients affected by extensive small cell lung cancer. The primary end-point of the trial was the objective response rate. 31 objective responses among 50 patients were considered necessary to proceed to a phase 3 trial. 48 patients were enrolled (median age 59 years). Treatment was very well tolerated. 3 patients (6.2%) had a complete response and 23 (47.9%) a partial response, for an overall response rate of 54.2% (95% CI: 39.2–68.6) Median time to progression was 5.7 months (95% CI: 5.2–6.2). Median survival was 9.6 months (95% CI: 7.2–14.6), with a median follow-up time of alive patients of 12 months. At 1 year, the probability of being progression-free or alive was 0.16 and 0.43, respectively. In conclusion, carboplatin plus paclitaxel as given in the present study is very well tolerated but not sufficiently active to warrant phase 3 comparison with standard chemotherapy regimens. © 2001 Cancer Research Campaign http://www.bjcancer.co

CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries

The open source MATLAB application CellGeo is a user-friendly computational platform that allows simultaneous, automated tracking and analysis of dynamic changes in cell shape, including protrusions ranging from filopodia to lamellipodia to growth cones.Cell biologists increasingly rely on computer-aided image analysis, allowing them to collect precise, unbiased quantitative results. However, despite great progress in image processing and computer vision, current computational approaches fail to address many key aspects of cell behavior, including the cell protrusions that guide cell migration and drive morphogenesis. We developed the open source MATLAB application CellGeo, a user-friendly computational platform to allow simultaneous, automated tracking and analysis of dynamic changes in cell shape, including protrusions ranging from filopodia to lamellipodia. Our method maps an arbitrary cell shape onto a tree graph that, unlike traditional skeletonization algorithms, preserves complex boundary features. CellGeo allows rigorous but flexible definition and accurate automated detection and tracking of geometric features of interest. We demonstrate CellGeo’s utility by deriving new insights into (a) the roles of Diaphanous, Enabled, and Capping protein in regulating filopodia and lamellipodia dynamics in Drosophila melanogaster cells and (b) the dynamic properties of growth cones in catecholaminergic a–differentiated neuroblastoma cells

p 291the distinctive study a biologically enriched phase ii study of second line folfiri aflibercept in prospectively stratified anti egfr resistant metastatic colorectal cancer patients with ras validated wild type status trial in progress

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Survival analysis of a multicentre, randomized phase 3 study on the optimization of the combination of bevacizumab with FOLFOX/OXXEL in patients with metastatic colorectal cancer (mCRC)

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