89 research outputs found
Entanglement vs. gap for one-dimensional spin systems
We study the relationship between entanglement and spectral gap for local
Hamiltonians in one dimension. The area law for a one-dimensional system states
that for the ground state, the entanglement of any interval is upper-bounded by
a constant independent of the size of the interval. However, the possible
dependence of the upper bound on the spectral gap Delta is not known, as the
best known general upper bound is asymptotically much larger than the largest
possible entropy of any model system previously constructed for small Delta. To
help resolve this asymptotic behavior, we construct a family of one-dimensional
local systems for which some intervals have entanglement entropy which is
polynomial in 1/Delta, whereas previously studied systems, such as free fermion
systems or systems described by conformal field theory, had the entropy of all
intervals bounded by a constant times log(1/Delta).Comment: 16 pages. v2 is final published version with slight clarification
Wear Minimization for Cuckoo Hashing: How Not to Throw a Lot of Eggs into One Basket
We study wear-leveling techniques for cuckoo hashing, showing that it is
possible to achieve a memory wear bound of after the
insertion of items into a table of size for a suitable constant
using cuckoo hashing. Moreover, we study our cuckoo hashing method empirically,
showing that it significantly improves on the memory wear performance for
classic cuckoo hashing and linear probing in practice.Comment: 13 pages, 1 table, 7 figures; to appear at the 13th Symposium on
Experimental Algorithms (SEA 2014
The Complete Spectrum of Yeast Chromosome Instability Genes Identifies Candidate CIN Cancer Genes and Functional Roles for ASTRA Complex Components
Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of mutations that cause CIN is only partly known and it is not possible to predict a priori all pathways whose disruption might lead to CIN. To address this issue, we generated a catalogue of CIN genes and pathways by screening ∼2,000 reduction-of-function alleles for 90% of essential genes in Saccharomyces cerevisiae. Integrating this with published CIN phenotypes for other yeast genes generated a systematic CIN gene dataset comprised of 692 genes. Enriched gene ontology terms defined cellular CIN pathways that, together with sequence orthologs, created a list of human CIN candidate genes, which we cross-referenced to published somatic mutation databases revealing hundreds of mutated CIN candidate genes. Characterization of some poorly characterized CIN genes revealed short telomeres in mutants of the ASTRA/TTT components TTI1 and ASA1. High-throughput phenotypic profiling links ASA1 to TTT (Tel2-Tti1-Tti2) complex function and to TORC1 signaling via Tor1p stability, consistent with the role of TTT in PI3-kinase related kinase biogenesis. The comprehensive CIN gene list presented here in principle comprises all conserved eukaryotic genome integrity pathways. Deriving human CIN candidate genes from the list allows direct cross-referencing with tumor mutational data and thus candidate mutations potentially driving CIN in tumors. Overall, the CIN gene spectrum reveals new chromosome biology and will help us to understand CIN phenotypes in human disease
The Elg1 Clamp Loader Plays a Role in Sister Chromatid Cohesion
Mutations in the ELG1 gene of yeast lead to genomic instability, manifested in high levels of genetic recombination, chromosome loss, and gross chromosomal rearrangements. Elg1 shows similarity to the large subunit of the Replication Factor C clamp loader, and forms a RFC-like (RLC) complex in conjunction with the 4 small RFC subunits. Two additional RLCs exist in yeast: in one of them the large subunit is Ctf18, and in the other, Rad24. Ctf18 has been characterized as the RLC that functions in sister chromatid cohesion. Here we present evidence that the Elg1 RLC (but not Rad24) also plays an important role in this process. A genetic screen identified the cohesin subunit Mcd1/Scc1 and its loader Scc2 as suppressors of the synthetic lethality between elg1 and ctf4. We describe genetic interactions between ELG1 and genes encoding cohesin subunits and their accessory proteins. We also show that defects in Elg1 lead to higher precocious sister chromatid separation, and that Ctf18 and Elg1 affect cohesion via a joint pathway. Finally, we localize both Ctf18 and Elg1 to chromatin and show that Elg1 plays a role in the recruitment of Ctf18. Our results suggest that Elg1, Ctf4, and Ctf18 may coordinate the relative movement of the replication fork with respect to the cohesin ring
Analysis of factors influencing the ultrasonic fetal weight estimation
Objective: The aim of our study was the evaluation of sonographic fetal weight estimation taking into consideration 9 of the most important factors of influence on the precision of the estimation. Methods: We analyzed 820 singleton pregnancies from 22 to 42 weeks of gestational age. We evaluated 9 different factors that potentially influence the precision of sonographic weight estimation ( time interval between estimation and delivery, experts vs. less experienced investigator, fetal gender, gestational age, fetal weight, maternal BMI, amniotic fluid index, presentation of the fetus, location of the placenta). Finally, we compared the results of the fetal weight estimation of the fetuses with poor scanning conditions to those presenting good scanning conditions. Results: Of the 9 evaluated factors that may influence accuracy of fetal weight estimation, only a short interval between sonographic weight estimation and delivery (0-7 vs. 8-14 days) had a statistically significant impact. Conclusion: Of all known factors of influence, only a time interval of more than 7 days between estimation and delivery had a negative impact on the estimation
PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae
About one-fifth of the genes in the budding yeast are essential for haploid viability and cannot be functionally assessed using standard genetic approaches such as gene deletion. To facilitate genetic analysis of essential genes, we and others have assembled collections of yeast strains expressing temperature-sensitive (ts) alleles of essential genes. To explore the phenotypes caused by essential gene mutation we used a panel of genetically engineered fluorescent markers to explore the morphology of cells in the ts strain collection using high-throughput microscopy. Here, we describe the design and implementation of an online database, PhenoM (Phenomics of yeast Mutants), for storing, retrieving, visualizing and data mining the quantitative single-cell measurements extracted from micrographs of the ts mutant cells. PhenoM allows users to rapidly search and retrieve raw images and their quantified morphological data for genes of interest. The database also provides several data-mining tools, including a PhenoBlast module for phenotypic comparison between mutant strains and a Gene Ontology module for functional enrichment analysis of gene sets showing similar morphological alterations. The current PhenoM version 1.0 contains 78 194 morphological images and 1 909 914 cells covering six subcellular compartments or structures for 775 ts alleles spanning 491 essential genes. PhenoM is freely available at http://phenom.ccbr.utoronto.ca/
Exponential Decay of Correlations Implies Area Law
We prove that a finite correlation length, i.e. exponential decay of
correlations, implies an area law for the entanglement entropy of quantum
states defined on a line. The entropy bound is exponential in the correlation
length of the state, thus reproducing as a particular case Hastings proof of an
area law for groundstates of 1D gapped Hamiltonians.
As a consequence, we show that 1D quantum states with exponential decay of
correlations have an efficient classical approximate description as a matrix
product state of polynomial bond dimension, thus giving an equivalence between
injective matrix product states and states with a finite correlation length.
The result can be seen as a rigorous justification, in one dimension, of the
intuition that states with exponential decay of correlations, usually
associated with non-critical phases of matter, are simple to describe. It also
has implications for quantum computing: It shows that unless a pure state
quantum computation involves states with long-range correlations, decaying at
most algebraically with the distance, it can be efficiently simulated
classically.
The proof relies on several previous tools from quantum information theory -
including entanglement distillation protocols achieving the hashing bound,
properties of single-shot smooth entropies, and the quantum substate theorem -
and also on some newly developed ones. In particular we derive a new bound on
correlations established by local random measurements, and we give a
generalization to the max-entropy of a result of Hastings concerning the
saturation of mutual information in multiparticle systems. The proof can also
be interpreted as providing a limitation on the phenomenon of data hiding in
quantum states.Comment: 35 pages, 6 figures; v2 minor corrections; v3 published versio
The Elg1-RFC Clamp-Loading Complex Performs a Role in Sister Chromatid Cohesion
It is widely accepted that of the four Replication Factor C (RFC) complexes (defined by the associations of either Rfc1p, Ctf18p, Elg1p or Rad24p with Rfc2p-Rfc5p), only Ctf18-RFC functions in sister chromatid cohesion. This model is based on findings that CTF18 deletion is lethal in combination with mutations in either CTF7ECO1 or MCD1 sister chromatid cohesion genes and that ctf18 mutant cells exhibit cohesion defects. Here, we report that Elg1-RFC not only participates in cohesion but performs a function that is distinct from that of Ctf18-RFC. The results show that deletion of ELG1 rescues both ctf7eco1 mutant cell temperature sensitivity and cohesion defects. Moreover, over-expression of ELG1 enhances ctf7eco1 mutant cell phenotypes. These findings suggest that the balance of Ctf7pEco1p activity depends on both Ctf18-RFC and Elg1-RFC. We also report that ELG1 deletion produces cohesion defects and intensifies the conditional phenotype of mcd1 mutant cells, further supporting a role for Elg1-RFC in cohesion. Attesting to the specificity of these interactions, deletion of RAD24 neither suppressed nor exacerbated cohesion defects in either ctf7eco1 or mcd1 mutant cells. While parallel analyses failed to uncover a similar role in cohesion for Rad24-RFC, it is well known that Rad24-RFC, Elg1-RFC and Ctf18-RFC play key roles in DNA damage responses. We tested and found that Ctf7pEco1p plays a significant role in Rad24-RFC-based DNA response pathways. In combination, these findings challenge current views and document new and distinct roles for RFC complexes in cohesion and for Ctf7pEco1p in DNA repair
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