49 research outputs found
Иринотекан в лечении колоректального рака. Обзор литературы
In 1998, oncologists got a brand new antitumor drug – irinotecan. It’s been already 18 years since its approval for second-line polychemotherapy of metastatic colorectal cancer. Indications for irinotecan use were significantly expanded since that time; it is now used in combination with other therapeutic agents for first- or second-line treatment of metastatic colorectal cancer, in combination with targeted drugs or separately; there are some studies assessing the use of irinotecan in neoadjuvant therapy. The article describes the history and modern schemes of irinotecan administration in treatment of colorectal cancer.С 1998 г. в арсенале онкологов появился принципиально новый противоопухолевый агент – иринотекан. С момента его одобрения в качестве препарата для проведения 2-й линии полихимиотерапии метастатического колоректального рака прошло уже 18 лет. За это время к применению иринотекана появилось большое количество показаний, его используют в различных сочетаниях с другими препаратами в качестве 1-й и 2-й линий терапии метастатического колоректального рака, в сочетании с таргетными препаратами и без, ведется ряд исследований по изучению работы препарата в неоадъювантном режиме. В статье рассматриваются история и современные схемы применения иринотекана в лечении колоректального рака
Description of the two-nucleon system on the basis of the Bargmann representation of the S matrix
For the effective-range function , a pole approximation that
involves a small number of parameters is derived on the basis of the Bargmann
representation of the matrix. The parameters of this representation, which
have a clear physical meaning, are related to the parameters of the Bargmann
matrix by simple equations. By using a polynomial least-squares fit to the
function at low energies, the triplet low-energy parameters of
neutron-proton scattering are obtained for the latest experimental data of
Arndt et al. on phase shifts. The results are fm, fm, and fm. With allowance for the values found for the
low-energy scattering parameters and for the pole parameter, the pole
approximation of the function provides an excellent description
of the triplet phase shift for neutron-proton scattering over a wide energy
range (MeV), substantially improving the
description at low energies as well. For the experimental phase shifts of Arndt
et al., the triplet shape parameters of the effective-range expansion
are obtained by using the pole approximation. The description of the phase
shift by means of the effective-range expansion featuring values found for the
low-energy scattering parameters proves to be fairly accurate over a broad
energy region extending to energy values approximately equal to the energy at
which this phase shift changes sign, this being indicative of a high accuracy
and a considerable value of the effective-range expansion in describing
experimental data on nucleon-nucleon scattering. The properties of the deuteron
that were calculated by using various approximations of the effective-range
function comply well with their experimental values.Comment: 39 pages, 3 figure