Method of producing water-soluble glucuronic acid derivatives of vitamin A

Water soluble glucuronic acid derivatives of vitamin A, including retinoyl β-glucuronide and retinyl β-glucuronide, having in vivo activity comparable to retinoicacid and retinol and methods of their preparation are disclosed

Ionization Cross-Sections of Atoms and Molecules by Electron Impact

Apparent ionization cross-sections of,several atoms and molecules for 70 ev electrons have been measured with the help of a mass spectrometer. By introducing a simple correction an attempt has been made to improve the method of Otvos and Stevenson for the calculation of the ionization cross-sections of atoms and molecules. With this correction, the additivity postulate for the molecular ionization cross-sections appears to hold better the additivity postulate for tho molecular ionization cross-sections appears to hold better

Non-teratogenic vitamin A preparation for women of child-bearing age

For treatment of acne the glucuronide of retinoic acid (retinoyl β-glucuronide) is orally administered to women of child-bearing age who are capable of conception. This therapy is safer than the oral administration of retinoic acid because retinoic acid glucuronide is essentially non-teratogenic at dose levels effective for the acne treatment. The retinoic acid glucuronide can be in all-trans or 13-cis form

Retinoic acid glucuronide preparations for application to the skin

A method and preparation are described for treating human skin with retinoic acid glucuronide (RAG) in a topical carrier. For treatment of acne or wrinkled skin, RAG can be applied in an effective amount which is nonirritating to the skin. Retinoid dermatitis, an objectionable side effect of topical application of retinoid compounds, can thereby be avoided

Piperine content variation in different Piper longum germplasms of North East India determined through RP-HPLC method

The present experiment was conducted at Assam Agricultural University, Jorhat with ten accessions including check variety of Piper Longum germplasm collected from different states of North Eastern region during 2013-14 and 2014-15.The piperine, a major alkaloid used in different therapeutic treatment, per cent content was determined from dried plant materials. Deionised water was used throughout the experiment and the chromatographic separation was carried out in an isocratic elution mode on RP-18 column with 5?m particle size, 4.6mm internal diameter and 250mm length. The mobile phase was a mixture of methanol and water (80: 20). The solvent flow rate was 1.0 ml/minwith injection volume 20 µL. The photo diode array detector wavelength was set at 342 nm for the identification of piperine in all extracts. The per cent piperine content in extract was found to be 42.36 per cent in germplasm PLJ-30.The highest per cent piperine content in fruit was recorded in PLJ-11(7.85%) followed by germplasm PLJ-9 (7.64) and significantly superior over check variety“Viswam”(5.15%). The descending order of piperine content in fruits among germplasm was PLJ-11?PLJ-09?PLJ-30?PLJ-17? PLJ-03? PLJ-19? check variety?PLJ-01? PLJ-20 and PLJ-16. It can be revealed from the present experiment that piper germplasm with high piperine content has a great scope for commercial cultivation as alkaloid piperine has high demand in pharmaceutical use

Lattice-driven magnetic transitions in Al(Fe,T)2X2 compounds

Systematic trends connect detailed composition, lattice parameters and magnetic transition temperatures in the ferromagnetic intermetallic compound AlT2X2 with the Mn2AlB2-type crystal structure, where T = Mn, Fe, Ni, Co and X = B, C. Data were derived from both literature reports and from experiments performed on synthesized samples (T = (Fe1−xNix)2, x = 0, 0.05, 0.1; X = (B0.9C0.1)2). It is observed that compositional variation alters specific bonds responsible for the magnetic phase transition response, which ranges from 200 K ≤ Tt ≤ 310 K. Elemental composition that provides changes in the c-axis length and the associated (T-T)c-axis interatomic distance contribute the largest bonding effects to magnetic phase transition temperature Tt, alterations. Overall, these results are attributed to the dependence of Tt on the specifics of the Fe sublattice occupancy, electronic state and T-T bonding. In contrast, Tt is found to be largely independent of the (b/a) axial ratios and the associated (T-X)b-axis/(T-X)(ac)-plane interatomic distance ratios, indicating that interatomic interactions along the a-axis have little effect on the Tt