A NEW METHOD OF TREATMENT OF FESTERING WOUNDS

Experimental researches were realized in 54 rats with. modeling of wound defects of lower extremities. Study of effectiveness of combined. local appIication of miliacyl and. light therapy in complex treatment of festering wounds was realized. in 20 patients and. another 20 patients with similar wounds were included in the control group. Clinical, microbiological, morphofunctionaI and experimental-histological researches proved high efficiency of local appIication of miliacyl and. light therapy in the complex treatment of festering wounds

CLINICAL AND MORPHOFUNCTIONAL CHARACTERISTICS OF PURULENT WOUNDS REPARATION AT THE USE OF MILIACYLE

Reparation of tissues of purulent wounds at the Miliacylum treatment under conditions of infection was studied on 54 white mongrel male rats with simulated wound defects. Clinical and morphofunctional studies proved high efficiency of Miliacylum. in the treatment of purulent wounds

ПРИМЕНЕНИЕ БИОКОМПОЗИТА «ЛИТАР» ДЛЯ ЛИКВИДАЦИИ ОСТАТОЧНЫХ ПОЛОСТЕЙ ПЕЧЕНИ В УСЛОВИЯХ ЭКСПЕРИМЕНТА

Experimental-histological justification for the use of composite material «LitAr» in combination with oxytocin has done to replace residual cavities in liver for optimal terms of regeneration. The data on the optimization of epithelial connective tissue relations that in the proliferative phase creates preconditions for elimination of defect regenerate tissue-specific parenchymatous elements of the liver. In series with the addition of oxytocin residual cavity liver is filled organotypic tissue elements of the regenerate more quickly.Проведено экспериментально-гистологическое обоснование применения композитного материала «ЛитАр» в сочетании с окситоцином для замещения остаточных полостей печени и для обеспечения оптимальных условий регенерации. Получены данные об оптимизации эпителиально-соединительнотканных взаимоотношений, что в пролиферативную фазу создает предпосылки для замещения дефекта тканеспецифическим регенератом паренхиматозных элементов печени. В сериях с добавлением окситоцина остаточная полость печени заполняется тканевыми элементами органотипического регенерата в более короткие сроки.

Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?

Objectives Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients. Methods We searched for, retrieved, and commented on specific literature regarding multiple functions of oxytocin with a special focus on its modulation of inflammatory, immune, and restorative functions. Results Available data gathered in animals and humans support the anti-inflammatory properties of oxytocin. The multiple anti-inflammatory effects of oxytocin have been demonstrated in vitro and in vivo in various animal models and also in humans in response to intravenous infusion of oxytocin. Furthermore, oxytocin has been documented to activate several types of protective and restorative mechanisms and to exert positive effects on the immune system. Conclusions In addition, to being anti-inflammatory, it may be hypothesised, that oxytocin may be less suppressive on adaptive immune systems, as compared with glucocorticoids. Finally, by its restorative effects coupled with its anti-stress and healing properties, oxytocin may shorten the recovery period of the Covid-19 patients

ПРИМЕНЕНИЕ МИЛИАЦИЛА И ФИЗИЧЕСКИХ МЕТОДОВ В ЛЕЧЕНИИ ТРОФИЧЕСКИХ ЯЗВ НИЖНИХ КОНЕЧНОСТЕЙ

The clinical studies included 340 patients with trophic ulcers in lower limbs. It is for the first time that the therapeutic efficacy of local application of Miliacyle combined with magnetolasertherapy has been studied in 124 patients with trophic ulcers (experimental group). The patients of the control group I (84 patients) were treated with topically applied Miliacyle and laser radiation. The patients of control group II (80 patients) were treated only with Miliacyle. In the control group III (52 patients) the 1% solution of Dioxydinum and Oleum Hippopheae were used. In some patients of each group only conservative therapy was used, and some patients underwent preoperative treatment prior to autodermaplasty and operations on veins of lower limbs. On the basis of clinical and morphological studies it is found that the process of ulcer healing occurs most favorably as result of combined use of Miliacyle and magnetolasertherapy.Клинические исследования включали 340 больных с трофическими язвами нижних конечностей. Впервые проведено изучение лечебной эффективности сочетанного местного применения милиацила и магнитолазеротерапии у 124 пациентов с трофическими язвами (основная группа). Для лечения больных I контрольной группы (84 пациента) местно применяли милиацил и лазерное излучение. Во II контрольной группе (80 больных) использовали только милиацил. В III контрольной группе (52 пациента) применяли местно 1% раствор диоксидина и облепиховое масло. У части больных каждой группы проведена только консервативная терапия, а у ряда пациентов выполнено предоперационное лечение перед аутодермопластикой, операциями на венах нижних конечностей. На основании клинических, морфологических исследований выявлено, что процесс заживления язв протекает наиболее благоприятно при применении милиацила и магнитолазеротерапии.

USE OF BIOCOMPOSITE «LITAR» TO ELIMINATE RESIDUAL LIVER CAVITIES IN CONDITIONS OF THE EXPERIMENT

Experimental-histological justification for the use of composite material «LitAr» in combination with oxytocin has done to replace residual cavities in liver for optimal terms of regeneration. The data on the optimization of epithelial connective tissue relations that in the proliferative phase creates preconditions for elimination of defect regenerate tissue-specific parenchymatous elements of the liver. In series with the addition of oxytocin residual cavity liver is filled organotypic tissue elements of the regenerate more quickly

Gender particulars of morphological phenotypes of the right atrial appendage myocardium in patients with chronic heart failure who underwent an open heart surgery

Background: For many decades, women in all age groups have a high risk of mortality and perioperative complications of cardiac surgery (CS), with its cause being unclear until now. Preoperative prediction of cardiovascular complications (CVC), based only on the clinical and instrumental criteria without taking gender into account, also remains unsuccessful. There is an opinion that the structural and functional changes in the myocardium, which exist before the operation, could significantly affect the patient's condition after cardiac surgery.Aim: To identify morphological and molecular predictors of unfavorable prognosis in chronic heart failure (CHF) patients of both genders after CS.Materials and methods: The study included 87 CHF patients of both genders referred for an elective cardiac surgery. Before the operation, a standard examination and treatment of CHF and concomitant disorders were performed. A sample of the right atrial appendage (RAA) myocardium that had been resected during the CS, was studied by histological, immunohistochemical (IHC) (expression of caspase-3, bcl-2, MMP-2, TIMP-1, p38α, CD-34) and morphometric methods. At days 10 to 14 after CS, the presence of CVC was assessed in all the participants. We examined the relationship between the development of CVC and morphological changes in the RAA myocardium before surgery, taking into account the patients' gender.Results: Compared to the group with the favorable postoperative course in the myocardium, in the male/female group with unfavorable post-CS course there was a significant reduction in the cardiomyocyte (CMC) diameter (13.26 ± 3.14; p < 0.01 / 13.99 ± 3.64; p < 0.01), the bulk density (BD) of CMC (55.4 ± 9.45; p < 0.01 / 51.22 ± 10.12; p < 0.01) vol. %, a trophic index (0.24 ± 0.1; p < 0.01 / 0.21 ± 0.06; p < 0.01), as well as a significant increase in the stromal BD (44.91 ± 9.23; p < 0.01 / 47.78 ± 10.12; p <0.01) vol. % and the Kernogan index (1.78 ± 0.49; p < 0.01 / 1.43 ± 0.64; p = 0.143). IHC analysis of the RAA myocardium in the male/female group with an unfavorable postoperative course showed an increase in the amount of caspase-3 (+) CMC (3.9 ± 0.46; p < 0.01 / 3.34 ± 0.4; p < 0.01), an increase in the activity of +/++/+++ p38α (3/30/69; p < 0.01 / 2/39/60; p < 0.01) %, the expression of MMP-2 (2/56/43; p < 0.01 / 0/68/31; p < 0.01) %, with a decrease in the expression of TIMP-1 (19/29/52; p < 0.01 / 8/24/67; p < 0.01) % and BD of CD-34 stromal cells (18.46 ± 8.5; p < 0.01 / 27.54 ± 5.88; p < 0.01) %, compared with groups with a favorable current.Сonclusion: The study showed the role of caspase-3, MMP-2, and CD-34 in the RAA myocardium as prognostic markers of CVC in the early postoperative period, as well as gender differences in modulation of the apoptotic pathways and inefficiency of anti-apoptotic mechanisms in the RAA myocardium. Based on the assessment of the RAA myocardial reorganization, an integral prognostic picture of the structural and functional changes in the myocardium has been proposed, which makes it possible to identify a special patient cohort with an exceptionally high risk of unfavorable course of the post-CS period

USE OF MILIACYLЕ AND PHYSICAL METHODS IN THE TREATMENT OF TROPHIC ULCERS OF LOWER LIMBS

The clinical studies included 340 patients with trophic ulcers in lower limbs. It is for the first time that the therapeutic efficacy of local application of Miliacyle combined with magnetolasertherapy has been studied in 124 patients with trophic ulcers (experimental group). The patients of the control group I (84 patients) were treated with topically applied Miliacyle and laser radiation. The patients of control group II (80 patients) were treated only with Miliacyle. In the control group III (52 patients) the 1% solution of Dioxydinum and Oleum Hippopheae were used. In some patients of each group only conservative therapy was used, and some patients underwent preoperative treatment prior to autodermaplasty and operations on veins of lower limbs. On the basis of clinical and morphological studies it is found that the process of ulcer healing occurs most favorably as result of combined use of Miliacyle and magnetolasertherapy