ИЗМЕНЕНИЯ ГОМЕОСТАЗА В РАННЕМ ПОСЛЕОПЕРАЦИОННОМ ПЕРИОДЕ ПОСЛЕ ТРАНСУРЕТРАЛЬНОЙ РЕЗЕКЦИИ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ И ПУТИ ПРОФИЛАКТИКИ РАЗВИТИЯ ОСЛОЖНЕНИЙ

The found changes in the blood coagulation system, serum and prostate tissue spectral analysis, and immunological changes show the development of occult disseminated intravascular coagulation and systemic inflammatory responses caused by endothelial damage, microcirculatory disorders, lipid peroxidation, and release of inflammatory factors. The findings will allow one to elaborate a tactic for medical prevention of complications.Выявленные изменения свертывающей системы крови, спектральный анализ сыворотки крови и ткани предстательной железы, изменения иммунной системы организма показывают развитие скрытого синдрома диссеминированного внутрисосудистого свертывания (ДВС-синдрома), системной воспалительной реакции, обусловленные повреждением эндотелия, нарушением микроциркуляции, перекисным окислением липидов, высвобождением факторов воспаления. Полученные результаты исследований позволяют выработать тактику медикаментозной профилактики осложнений

Non-invasive optical method for evaluating the oxygen status in breast neoplasms

The paper presents the results from a study of the breast oxygen status by diffuse optical tomography (DOT). Detection of breast tissue at wavelengths of 684, 794, and 850 nm could provide information on the distribution of basic tissue chromophores: oxygenized and deoxygenized hemoglobin. Normal breast tissue was characterized by the even distribution of these compounds and stabilization of their level. In breast cancer, the distribution of oxy- and deoxyhemoglobin was noted for uneven distribution and blood oxygen saturation was lower in the projection of a tumor nodule. The blood oxygen saturation data obtained by DOT demonstrate physiological differ- ences between normal and tumor tissues in different tumor areas

ИЗМЕНЕНИЯ ГОМЕОСТАЗА В РАННЕМ ПОСЛЕОПЕРАЦИОННОМ ПЕРИОДЕ ПОСЛЕ ТРАНСУРЕТРАЛЬНОЙ РЕЗЕКЦИИ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ И ПУТИ ПРОФИЛАКТИКИ ОСЛОЖНЕНИЙ

During the study, the authors assessed changes in the blood coagulation system and made a spectral analysis of serum and prostate tissue. They revealed immunological changes suggesting occult disseminated intravascular coagulation, an evolving systemic inflammatory response and the latter caused by endothelial damage, microcirculatory disorders, lipid peroxidation, and release of inflammatory factors. The findings permit a tactic for medical prevention of complications to be elaborated.В ходе исследования проведена оценка изменений свертывающей системы крови, выполнен спектральный анализ сыворотки крови и ткани предстательной железы. Выявлены изменения иммунной системы организма, свидетельствующие о наличии скрытого синдрома диссеминированного внутрисосудистого свертывания крови, развитии системной воспалительной реакции и обусловленные повреждением эндотелия, нарушением микроциркуляции, перекисным окислением липидов, высвобождением факторов воспаления. Полученные результаты позволяют выработать тактику медикаментозной профилактики осложнений

ПРОСТАТИЧЕСКАЯ ИНТРАЭПИТЕЛИАЛЬНАЯ НЕОПЛАЗИЯ: ГИСТОЛОГИЧЕСКИЕ АССОЦИАЦИИ

The authors determined the detection rates of prostatic intraepithelial neoplasia (PIN) in 2317 patients with benign prostatic hyperplasia (BPH) and prostate cancer (PC); and those of chronic prostatitis and fibrosis in patients with PIN, BPH, or PC. There was no difference in median age between the groups. PC was found to be more concurrent with PIN 2 than with BPH. The severer inflammation or fibrosis is, more likely there is a concomitance with PIN 2 or PC. There is evidence for the theory of inflammation is a factor of carcinogenesis. Prostatic fibrosis may also initiate carcinogenesis.Определена частота выявления простатической интраэпителиальной неоплазии (ПИН) у 2317 пациентов с доброкачественной гиперплазией (ДГПЖ) и раком (РПЖ) предстательной железы, хронического простатита и фиброза у больных ПИН, ДГПЖ и РПЖ. Средний возраст пациентов не имеет отличий. РПЖ чаще сочетается с ПИН 2, чем ДГПЖ. Чем выраженнее воспаление или фиброз, тем вероятнее сочетание с ПИН 2 или РПЖ. Получено подтверждение теории о воспалении как факторе канцерогенеза. Фиброз предстательной железы также может инициировать канцерогенез

EARLY POSTOPERATIVE HOMEOSTATIC CHANGES AFTER TRANSURETHRAL RESECTION OF THE PROSTATE AND WAYS OF PREVENTING COMPLICATIONS

<span>The found changes in the blood coagulation system, serum and prostate tissue spectral analysis, and immunological changes show the development of occult disseminated intravascular coagulation and systemic inflammatory responses caused by endothelial damage, microcirculatory disorders, lipid peroxidation, and release of inflammatory factors. The findings will allow one to elaborate a tactic for medical prevention of complications.</span

EARLY POSTOPERATIVE HOMEOSTATIC CHANGES AFTER TRANSURETHRAL RESECTION OF THE PROSTATE AND WAYS OF PREVENTING ITS COMPLICATIONS

During the study, the authors assessed changes in the blood coagulation system and made a spectral analysis of serum and prostate tissue. They revealed immunological changes suggesting occult disseminated intravascular coagulation, an evolving systemic inflammatory response and the latter caused by endothelial damage, microcirculatory disorders, lipid peroxidation, and release of inflammatory factors. The findings permit a tactic for medical prevention of complications to be elaborated.</p

PROSTATIC INTRAEPITHELIAL NEOPLASIA: HISTOLOGICAL ASSOCIATIONS

The authors determined the detection rates of prostatic intraepithelial neoplasia (PIN) in 2317 patients with benign prostatic hyperplasia (BPH) and prostate cancer (PC); and those of chronic prostatitis and fibrosis in patients with PIN, BPH, or PC. There was no difference in median age between the groups. PC was found to be more concurrent with PIN 2 than with BPH. The severer inflammation or fibrosis is, more likely there is a concomitance with PIN 2 or PC. There is evidence for the theory of inflammation is a factor of carcinogenesis. Prostatic fibrosis may also initiate carcinogenesis

PROSTATIC INTRAEPITHELIAL NEOPLASIA: HISTOLOGICAL ASSOCIATIONS

The authors determined the detection rates of prostatic intraepithelial neoplasia (PIN) in 2317 patients with benign prostatic hyperplasia (BPH) and prostate cancer (PC); and those of chronic prostatitis and fibrosis in patients with PIN, BPH, or PC. There was no difference in median age between the groups. PC was found to be more concurrent with PIN 2 than with BPH. The severer inflammation or fibrosis is, more likely there is a concomitance with PIN 2 or PC. There is evidence for the theory of inflammation is a factor of carcinogenesis. Prostatic fibrosis may also initiate carcinogenesis