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ΠΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ Π²ΡΡΠ°Π²ΠΊΠΈ/Π΄Π΅Π»Π΅ΡΠΈΠΈ Π³Π΅Π½Π° ΠΠΠ€ ΡΠ²ΡΠ·Π°Π½ Ρ Π³Π»ΠΈΠΎΠ±Π»Π°ΡΡΠΎΠΌΠΎΠΉ Ρ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΡΠ°Π½Π°: ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ»ΡΡΠ°ΠΉ-ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ
Background. The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been reported to be associated with the pathogenesis and development of human cancers.This study aimed to assess the potential association between ACE (I/D) polymorphism and glioblastoma in an Iranian population.Material and Methods. This case-control study was conducted on 80 patients with glioblastoma and 80 healthy blood donors as controls. Gap-polymerase chain reaction (Gap-PCR) was used to determine the ACE (I/D) genotypes. PCR products were separated and measured by electrophoresis on a 2 % agarose gel.Results. Analysis of demographic data showed a significant difference in the family history of cancer between the case and control groups (p=0.03). The distribution of ACE gene variants including II, ID, and DD genotypes was also calculated, and significant differences were seen in the DD genotype (p=0.03) and D allele (p=0.04) between the glioblastoma cases and controls.Conclusion. ACE gene polymorphism was associated with glioblastoma in the study population. Further studies are needed to approve this finding.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ. ΠΠ΅Π΄Π°Π²Π½ΠΎ ΡΠΎΠΎΠ±ΡΠ°Π»ΠΎΡΡ, ΡΡΠΎ ΠΈΠ½ΡΠ΅ΡΡΠΈΠΎΠ½Π½ΠΎ-Π΄Π΅Π»Π΅ΡΠΈΠΎΠ½Π½ΡΠΉ (I/D) ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ Π³Π΅Π½Π° Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½-ΠΏΡΠ΅Π²ΡΠ°ΡΠ°ΡΡΠ΅Π³ΠΎ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ° (ΠΠΠ€) ΡΠ²ΡΠ·Π°Π½ Ρ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·ΠΎΠΌ ΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΡΠ°ΠΊΠ° ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»Π° ΠΎΡΠ΅Π½ΠΊΠ° ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ I/D ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠΎΠΌ Π³Π΅Π½Π° ΠΠΠ€ ΠΈ Π³Π»ΠΈΠΎΠ±Π»Π°ΡΡΠΎΠΌΠΎΠΉ Ρ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΡΠ°Π½Π°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ»ΡΡΠ°ΠΉ-ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΡΠ°ΡΡΠ²ΠΎΠ²Π°Π»ΠΈ 80 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π³Π»ΠΈΠΎΠ±Π»Π°ΡΡΠΎΠΌΠΎΠΉ ΠΈ 80 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π΄ΠΎΠ½ΠΎΡΠΎΠ² Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π³ΡΡΠΏΠΏΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ. ΠΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½Π°Ρ ΡΠ΅ΠΏΠ½Π°Ρ ΡΠ΅Π°ΠΊΡΠΈΡ (Gap-PCR) ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»Π°ΡΡ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π³Π΅Π½ΠΎΡΠΈΠΏΠΎΠ² I/D ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° AΠΠ€. ΠΠ¦Π -ΠΏΡΠΎΠ΄ΡΠΊΡΡ ΡΠ°Π·Π΄Π΅Π»ΡΠ»ΠΈ ΠΈ ΠΈΠ·ΠΌΠ΅ΡΡΠ»ΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΡΠΎΡΠ΅Π·ΠΎΠΌ Π² 2 % Π°Π³Π°ΡΠΎΠ·Π½ΠΎΠΌ Π³Π΅Π»Π΅.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ½Π°Π»ΠΈΠ· Π΄Π΅ΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°Π» Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠ°Π·Π½ΠΈΡΡ Π² ΡΠ΅ΠΌΠ΅ΠΉΠ½ΠΎΠΉ ΠΈΡΡΠΎΡΠΈΠΈ ΡΠ°ΠΊΠ° ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ°ΠΌΠΈ (p=0,03). ΠΡΠ»ΠΎ ΡΠ°ΡΡΡΠΈΡΠ°Π½ΠΎ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² Π³Π΅Π½Π° ΠΠΠ€, Π²ΠΊΠ»ΡΡΠ°Ρ Π³Π΅Π½ΠΎΡΠΈΠΏΡ II, ID ΠΈ DD, ΠΈ Π±ΡΠ»ΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² Π³Π΅Π½ΠΎΡΠΈΠΏΠ΅ DD (p=0,03) ΠΈ Π°Π»Π»Π΅Π»Π΅ D (p=0,04) ΠΌΠ΅ΠΆΠ΄Ρ Π³ΡΡΠΏΠΏΠΎΠΉ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ Π³Π»ΠΈΠΎΠ±Π»Π°ΡΡΠΎΠΌΠΎΠΉ ΠΈ ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌ Π³Π΅Π½Π° AΠΠ€ Π±ΡΠ» ΡΠ²ΡΠ·Π°Π½ Ρ Π³Π»ΠΈΠΎΠ±Π»Π°ΡΡΠΎΠΌΠΎΠΉ Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ ΠΏΠΎΠΏΡΠ»ΡΡΠΈΠΈ. ΠΠ΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΡΡΠΎΠ±Ρ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΡΡ ΡΡΠΈ Π΄Π°Π½Π½ΡΠ΅