22 research outputs found

    Addition of Dichlorocarbene to Diethyl Methylsodiomalonate

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    Synthesis and antitumor evaluations of 1, 8-bis[(2-aminoethyl) amino]anthracene-9,10-diones

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    Bull.Chem.Soc.Ethiop.,2(2), 69-72 (1988)

    Ni2+ and Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlapping sites

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    Transition metal complexes allow fine tuning of DNA binding affinity and selectivity. Here we report on the nucleic acid recognition properties of a phenanthroline-based ligand coordinated to Ni(2+) or Cu(2+). The resulting complexes clearly bind to telomeric G-quadruplexes at different sites according to the nature of the bound metal ion
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