The effect of implant placement and simultaneous soft tissue augmentation in the esthetic zone using either connective tissue autograft or acellular dermal matrix allograft on peri-implant hard and soft tissue healing.

Aims. The primary aims of this randomized, controlled, blinded clinical trial were to compare the hard and soft tissue response following either a connective tissue (CT) or acellular dermal matrix (ADM) graft placed simultaneously with a laser-grooved implant. Methods. Twenty-five patients received a single tooth implant in the maxillary anterior that was bordered by two teeth. Patients were randomly selected, using to coin toss, to receive either an ADM (test) or a CT (control) graft. At the 2-month appointment, the implant was uncovered and a lab-fabricated provisional was placed. At the 4-month appointment, following 2 months of tissue shaping, a fixture level impression was obtained to capture the emergence profile. The final restoration was constructed and placed. Subjective and objective evaluations of the implant esthetics were obtained at the 6-month follow-up. Results. Soft tissue thickness at the crest for the CT group and ADM groups at 4 months was 2.8 mm and 2.9 mm respectively. ADM showed a greater increase in thickness than CT, but the gain was not statistically significant. Facial recession at 6 months for the CT group was 0.3 ± 0.4 mm and ADM group was 0.5 ± 0.5 mm (p \u3e 0.05). Gingival margin harmony was 64% (9 of 14) for the CT group and 45% (5 of 11) for the ADM group. Papilla harmony was achieved in 36% (5 of 14) of cases in the CT group and 27% (3 of 11) for the ADM group. Using the Jemt papilla index, the ADM group had 2: 50% papilla fill in 100% of sites (22 of 22) while the CT group had 93% (26 of 28) of sites. Implant platform to osseous crest, at 6 months, for the CT group was -0.4 ± 0.4 mm for the mesial and -0.2 ± 0.3 mm for the distal (p \u3c 0.05). The ADM group was -0.3 ± 0.5 mm for the mesial (p \u3c 0.05) and -0.2 ± 0.4 mm for the distal. The Pink Esthetic Score was 11.6 ± 1.5 for the CT group and 11.7 ± 1.6 for the ADM group. The White Esthetic score was 8.2 ± 1.3 mm for the CT group and 8.7 ± 1.5 mm for the ADM group. Patient\u27s subjective esthetic scores showed patients were equally satisfied with both treatment groups. Conclusions. Facial recession and gingival margin harmony were similar for both treatment groups. Jemt papilla index scores and papilla harmony were similar for both groups. Loss of osseous crest on the mesial and distal of the implants was similar in both treatment groups and was greatest between times 2 to 6 months. Subjective patient assessment of esthetics using the Visual Analog Scale was similar for CT and ADM groups

MSIS 2006 Curriculum Preview

The MSIS 2000 curriculum is now over 5 years old. That curriculum (the first revisions for the MS program since 1982) was widely adopted by IS departments throughout the world. A committee established jointly by AIS and ACM started working in summer 2003 on revising and updating the MS curriculum based on the experience of the adopting schools. The work is nearing completion. This paper describes the state of the revisions as of April 2005

MSIS 2006: Model Curriculum and Guidelines for Graduate Degree Programs in Information Systems

This article presents the MSIS 2006 Model Curriculum and Guidelines for Graduate Degree Programs in Information Systems. As with MSIS 2000 and its predecessors, the objective is to create a model for schools designing or revising an MS curriculum in Information Systems. The curriculum was designed by a joint committee of the Association for Information Systems and the Association for Computing Machinery. MSIS2006 is a major update of MSIS 2000. Features include increasing the number of required courses from 10 to 12 while revising prerequisites, introducing new courses and revising existing courses to modernize the curriculum, and alternatives for phased upgrading from MSIS2000 to MSIS 2006. As with the previous curriculum, it is the product of detailed consultation with the IS community. The curriculum received the endorsement of 8 major IS professional groups

MMOGs as Emerging Opportunities for Research on Virtual Organizations and Teams

Massively Multiplayer Online Games (MMOG) offer new promising opportunities to research virtual organizations and teams. The characteristics of MMOGs allow researchers to obtain objective data from a large and multi-national population. Lasting over months or even years, MMOGs facilitate longitudinal studies and ensure a high involvement of participants. Moreover, collecting data from online surveys and game servers keeps the costs of MMOG studies low. In this paper, we illustrate how research in MMOGs can utilize these opportunities to overcome some limitations of traditional research environments. Further we discuss the diverse information and communication technology (ICT) usage in MMOGs and therefore argue that research in MMOGs can provide a glimpse into the future application of ICT in real life organizations

MSIS 2000: Model Curriculum and Guidelines for Graduate Degree Programs in Information Systems

This article contains the official text of the MSIS 2000 model curriculum as approved by both the Association for Computing Machinery and the Association for Information Systems. It is presented here in its original form

Computational and Serologic Analysis of Novel and Known Viruses in Species Human Adenovirus D in Which Serology and Genomics Do Not Correlate

In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To better understand the isolated virus, the genome was sequenced and analyzed using bioinformatic and phylogenomic analysis. The results suggest that this novel virus, which is provisionally named HAdV-D59, may have been created from multiple recombination events. Specifically, the penton, hexon, and fiber genes have high nucleotide identity to HAdV-D19C, HAdV-D25, and HAdV-D56, respectively. Serological results demonstrated that HAdV-D59 has a neutralization profile that is similar yet not identical to that of HAdV-D25. Furthermore, we observed a two-fold difference between the ability of HAdV-D15 and HAdV-D25 to be neutralized by reciprocal antiserum indicating that the two hexon proteins may be more similar in epitopic conformation than previously assumed. In contrast, hexon loops 1 and 2 of HAdV-D15 and HAdV-D25 share 79.13 and 92.56 percent nucleotide identity, respectively. These data suggest that serology and genomics do not always correlate

Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status

There have been hints that nonviral cancer antigens are differentially expressed in human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC). Antibody responses (AR) to cancer antigens may be used to indirectly determine cancer antigen expression in the tumor using a noninvasive and tissue-saving liquid biopsy. Here, we set out to characterize AR to a panel of nonviral cancer antigens in HPV-positive and HPV-negative HNSCC patients. A fluorescent microbead multiplex serology to 29 cancer antigens (16 cancer-testis antigens, 5 cancer-retina antigens and 8 oncogenes) and 29 HPV-antigens was performed in 382 HNSCC patients from five independent cohorts (153 HPV-positive and 209 HPV-negative). AR to any of the cancer antigens were found in 272/382 patients (72%). The ten most frequent AR were CT47, cTAGE5a, c-myc, LAGE-1, MAGE-A1, -A3, -A4, NY-ESO-1, SpanX-a1 and p53. AR to MAGE-A3, MAGE-A9 and p53 were found at significantly different prevalences by HPV status. An analysis of AR mean fluorescent intensity values uncovered remarkably different AR clusters by HPV status. To identify optimal antigen selections covering a maximum of patients with ≤10 AR, multiobjective optimization revealed distinct antigen selections by HPV status. We identified that AR to nonviral antigens differ by HPV status indicating differential antigen expression. Multiplex serology may be used to characterize antigen expression using serum or plasma as a tissue-sparing liquid biopsy. Cancer antigen panels should address the distinct antigen repertoire of HPV-positive and HPV-negative HNSCC

Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study

BACKGROUND: In a recently performed survey with 4000 randomly selected persons, 68 (7.2 %) of 948 respondents reported intolerance and/or allergy-like symptoms to wine. The aim of this study was to analyze whether a real sensitization to wine proteins could be confirmed by diagnostic and/or immunological settings. FINDINGS: For this purpose, 19 subjects with self-reported intolerance to wine of the invited subjects and 10 controls without a history of intolerance participated in an allergological examination (skin prick test, ImmunoCAP for determination of specific IgE antibodies, CAST for testing basophil activation, ImmunoBlot for testing specificity of IgE-antibodies). For the allergological work-up red and white grapes, selected wines, and the purified lipid transfer protein (LTP), a known grape allergen, were used. 7 subjects showed evidence of IgE sensitization to wine or grape extracts, including one control. One participant with symptoms of intolerance showed a positive skin prick test to red grape, a positive ImmunoCAP to grape, a positive cellular antigen stimulation test (CAST) and inhibition of Western blot by removal of cross-reactive carbohydrate determinants (CCD). CONCLUSION: The presented study focused on the grape protein-related IgE-mediated cause of intolerance to wine (true allergy) and not on other wine components or fining agents (other forms of intolerance). A sensitization to grape and wine proteins was observed in our cohort. In one case, this reactivity could be explained by cross-reactivity to CCD. The results of this pilot study need to be validated in greater cohorts