19 research outputs found
Langerhans cell histiocytosis with involvement of the pons: case report
Central nervous system involvement is uncommon in Langerhans cell
histiocytosis. The suprasellar region is more frequently affected. There
have been few reports of involvement of the brain parenchyma shown on CT
or MRI, We present a case of involvement of the pens, showing marked
contrast enhancement on MRI
Bone lesions with soft-tissue mass: Magnetic resonance imaging diagnosis of lymphomatous involvement of the bone marrow versus multiple myeloma and bone metastases
Bone metastases from solid primary tumors, as well as multiple myeloma
and secondary lymphoma may all present with bone lesions and associated
soft-tissue masses on magnetic resonance images of the spine. Tn bone
metastases and myeloma, the cortex of the affected bone is usually
destroyed and a bulging contour is observed at the site of extraosseous
spread. In cases of lymphomatous involvement of the bone marrow,
however, we have observed that spread to the extraosseous soft-tissues
occurs without alteration of the shape or contour of the affected bone.
In order to assess whether this pattern of spread is indeed suggestive
or even diagnostic of lymphoma of the bone marrow, we reviewed spinal
bone marrow MR images of 66 patients, with bone metastases from solid
primary tumors (33 patients), multiple myeloma (20 patients) and stage
TV lymphoma with bone marrow involvement (13 patients), who had bone
lesions and contiguous soft-tissue masses. If tumor was present on
either side of the bony cortex but the contour of the affected bone was
preserved, a “wrap-around” sign was diagnosed. A “wrap-around”
sign was found in 12 of the 13 patients with lymphoma but in none of the
patients with metastases or myeloma.
On MR images of the bone marrow, the demonstration of tumor spread
beyond the bony cortex without disruption of the outline of the diseased
bone may favor the diagnosis of lymphoma more than that of metastases or
multiple myeloma
CT appearance of solitary and multiple cystic and cavitary lung lesions
Cystic and cavitary lung lesions constitute a spectrum of pulmonary
diseases diagnosed in both children and adults. We reviewed the CT
findings of the most common cystic and cavitary lung lesions and we
defined useful morphological criteria that will help radiologists to
distinguish benign from malignant cavitary lesions. However, in many
cases the considerable overlap in morphological features of benign and
malignant cavities renders transthoracic needle biopsy necessary to
establish the correct diagnosis
Male breast myofibroblastoma and MR findings
Myofibroblastoma of the breast is a rare benign tumor seen predominantly
in men in the sixth to seventh decades of life. We present a case of
breast myofibroblastoma in a man and describe the mammographic,
sonographic, and MR findings
Progestin may modify the effect of low-dose hormone therapy on mammographic breast density
Objectives To evaluate the effect on breast density of two low-dose hormone therapy regimens identical in their estrogen component but different in the progestin. Methods A total of 81 non-hysterectomized postmenopausal women were allocated either to 17β-estradiol 1 mg and norethisterone acetate 0.5 mg E2NETA, n 43 or to 17β-estradiol 1 mg and drospirenone 2 mg E2DRSP, n 38. Treatment was continuous and lasted 12 months. The main outcomes were the changes in breast density according to the Wolfe classification between baseline and 12-month mammograms. Results Involution of the fibroglandular tissue was not seen in either of the treatment groups. Under E2NETA, breast density increased in seven women 16.3. In contrast, only three women 7.9 exhibited a density increase under E2DRSP. Conclusions Although hormone therapy appears to suspend breast involution, it does not increase breast density in the majority of treated women. Progestins differing in pharmacological properties may have a variable impact on breast density. © 2009 International Menopause Society