A Catalog of 1022 Bright Contact Binary Stars

In this work we describe a large new sample of contact binary stars extracted in a uniform manner from sky patrol data taken by the ROTSE-I telescope. Extensive ROTSE-I light curve data is combined with J, H, and K band near-infrared data taken from the Two Micron All-Sky Survey (2MASS) to add color information. Contact binaries candidates are selected using the observed period-color relation. Candidates are confirmed by visual examination of the light curves. To enhance the utility of this catalog, we derive a new J-H period-color-luminosity relation and use this to estimate distances for the entire catalog. From these distance estimates we derive an estimated contact binary space density of (1.7 +/- 0.6) x 10^-5 pcs^-3.Comment: 26 pages, 12 figures, accepted for publication in A

Abundances in Stars from the Red Giant Branch Tip to the Near the Main Sequence in M71: I. Sample Selection, Observing Strategy and Stellar Parameters

We present the sample for an abundance analysis of 25 members of M71 with luminosities ranging from the red giant branch tip to the upper main sequence. The spectra are of high dispersion and of high precision. We describe the observing strategy and determine the stellar parameters for the sample stars using both broad band colors and fits of H$\alpha$ profiles. The derived stellar parameters agree with those from the Yale$^2$ stellar evolutionary tracks to within 50 -- 100K for a fixed log g, which is within the level of the uncertainties.Comment: Minor changes to conform to version accepted for publication, with several new figures (Paper 1 of a pair

Photometric Analysis of Recently Discovered Eclipsing Binary GSC 00008-00901

Photometric analysis of $BVR_C$ light curves of newly discovered eclipsing binary GSC 0008-00901 is presented. The orbital period is improved to 0.28948(11) days. Photometric parameters are determined, as well. The analysis yielded to conclusion that system is an over-contact binary of W UMa type with components not in thermal contact. The light curves from 2005 show the presence of a spot on the surface of one of the components, while light curves from 2006 are not affected by maculation.Comment: Accepted for publication in Astrophysics & Space Scienc

Discordant assessment of tumor biomarkers by histopathological and molecular assays in the EORTC randomized controlled 10041/BIG 03-04 MINDACT trial breast cancer

Accurate identification of breast cancer patients most likely to benefit from adjuvant systemic therapies is crucial. Better understanding of differences between methods can lead to an improved ER, PgR, and HER-2 assessment. The purpose of this preplanned translational research is to investigate the correlation of central IHC/FISH assessments with microarray mRNA readouts of ER, PgR, and HER-2 status in the MINDACT trial and to determine if any discordance could be attributed to intratumoral heterogeneity or the DCIS and normal tissue components in the specimens. MINDACT is an international, prospective, randomized, phase III trial investigating the clinical utility of MammaPrint in selecting patients with early breast cancer for adjuvant chemotherapy (n = 6694 patients). Gene-expression data were obtained by TargetPrint; IHC and/or FISH were assessed centrally (n = 5788; 86 %). Macroscopic and microscopic evaluation of centrally submitted FFPE blocks identified 1427 cases for which the very same sample was submitted for gene-expression analysis. TargetPrint ER had a positive agreement of 98 %, and a negative agreement of 95 % with central pathology. Corresponding figures for PgR were 85 and 94 % and for HER-2 72 and 99 %. Agreement of mRNA versus central protein was not different when the same or a different portion of the tumor tissue was analyzed or when DCIS and/or normal tissue was included in the sample subjected to mRNA assays. This is the first large analysis to assess the discordance rate between protein and mRNA analysis of breast cancer markers, and to look into intratumoral heterogeneity, DCIS, or normal tissue components as a potential cause of discordance. The observed difference between mRNA and protein assessment for PgR and HER-2 needs further research; the present analysis does not support intratumoral heterogeneity or the DCIS and normal tissue components being likely causes of the discordance.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Physical Orbit for Lambda Virginis and a Test of Stellar Evolution Models

Lambda Virginis (LamVir) is a well-known double-lined spectroscopic Am binary with the interesting property that both stars are very similar in abundance but one is sharp-lined and the other is broad-lined. We present combined interferometric and spectroscopic studies of LamVir. The small scale of the LamVir orbit (~20 mas) is well resolved by the Infrared Optical Telescope Array (IOTA), allowing us to determine its elements as well as the physical properties of the components to high accuracy. The masses of the two stars are determined to be 1.897 Msun and 1.721 Msun, with 0.7% and 1.5% errors respectively, and the two stars are found to have the same temperature of 8280 +/- 200 K. The accurately determined properties of LamVir allow comparisons between observations and current stellar evolution models, and reasonable matches are found. The best-fit stellar model gives LamVir a subsolar metallicity of Z=0.0097, and an age of 935 Myr. The orbital and physical parameters of LamVir also allow us to study its tidal evolution time scales and status. Although currently atomic diffusion is considered to be the most plausible cause of the Am phenomenon, the issue is still being actively debated in the literature. With the present study of the properties and evolutionary status of LamVir, this system is an ideal candidate for further detailed abundance analyses that might shed more light on the source of the chemical anomalies in these A stars.Comment: 43 Pages, 13 figures. Accepted for publication in Ap

A Consistency Test of Spectroscopic Gravities for Late-Type Stars

Chemical analyses of late-type stars are usually carried out following the classical recipe: LTE line formation and homogeneous, plane-parallel, flux-constant, and LTE model atmospheres. We review different results in the literature that have suggested significant inconsistencies in the spectroscopic analyses, pointing out the difficulties in deriving independent estimates of the stellar fundamental parameters and hence,detecting systematic errors. The trigonometric parallaxes measured by the HIPPARCOS mission provide accurate appraisals of the stellar surface gravity for nearby stars, which are used here to check the gravities obtained from the photospheric iron ionization balance. We find an approximate agreement for stars in the metallicity range -1 <= [Fe/H] <= 0, but the comparison shows that the differences between the spectroscopic and trigonometric gravities decrease towards lower metallicities for more metal-deficient dwarfs (-2.5 <= [Fe/H] <= -1.0), which casts a shadow upon the abundance analyses for extreme metal-poor stars that make use of the ionization equilibrium to constrain the gravity. The comparison with the strong-line gravities derived by Edvardsson (1988) and Fuhrmann (1998a) confirms that this method provides systematically larger gravities than the ionization balance. The strong-line gravities get closer to the physical ones for the stars analyzed by Fuhrmann, but they are even further away than the iron ionization gravities for the stars of lower gravities in Edvardsson's sample. The confrontation of the deviations of the iron ionization gravities in metal-poor stars reported here with departures from the excitation balance found in the literature, show that they are likely to be induced by the same physical mechanism(s).Comment: AAS LaTeX v4.0, 35 pages, 10 PostScript files; to appear in The Astrophysical Journa

Sprouty2 in the Dorsal Hippocampus Regulates Neurogenesis and Stress Responsiveness in Rats

Both the development and relief of stress-related psychiatric conditions such as major depression (MD) and post-traumatic stress disorder (PTSD) have been linked to neuroplastic changes in the brain. One such change involves the birth of new neurons (neurogenesis), which occurs throughout adulthood within discrete areas of the mammalian brain, including the dorsal hippocampus (HIP). Stress can trigger MD and PTSD in humans, and there is considerable evidence that it can decrease HIP neurogenesis in laboratory animals. In contrast, antidepressant treatments increase HIP neurogenesis, and their efficacy is eliminated by ablation of this process. These findings have led to the working hypothesis that HIP neurogenesis serves as a biomarker of neuroplasticity and stress resistance. Here we report that local alterations in the expression of Sprouty2 (SPRY2), an intracellular inhibitor of growth factor function, produces profound effects on both HIP neurogenesis and behaviors that reflect sensitivity to stressors. Viral vector-mediated disruption of endogenous Sprouty2 function (via a dominant negative construct) within the dorsal HIP of adult rats stimulates neurogenesis and produces signs of stress resilience including enhanced extinction of conditioned fear. Conversely, viral vector-mediated elevation of SPRY2 expression intensifies the behavioral consequences of stress. Studies of these manipulations in HIP primary cultures indicate that SPRY2 negatively regulates fibroblast growth factor-2 (FGF2), which has been previously shown to produce antidepressant- and anxiolytic-like effects via actions in the HIP. Our findings strengthen the relationship between HIP plasticity and stress responsiveness, and identify a specific intracellular pathway that could be targeted to study and treat stress-related disorders

The photometric-amplitude and mass-ratio distributions of contact binary stars

The distribution of the light-variation amplitudes, A(a), in addition to determining the number of undiscovered contact binary systems falling below photometric detection thresholds and thus lost to statistics, can serve as a tool in determination of the mass-ratio distribution, Q(q), which is very important for understanding of the evolution of contact binaries. Calculations of the expected A(a) show that it tends to converge to a mass-ratio dependent constant value for a->0. Strong dependence of A(a) on Q(q) can be used to determine the latter distribution, but the technique is limited by the presence of unresolved visual companions and by blending in crowded areas of the sky. The bright-star sample to 7.5 magnitude is too small for an application of the technique while the the Baade's Window sample from the OGLE project may suffer stronger blending; thus the present results are preliminary and illustrative only. Estimates based on the Baade's Window data from the OGLE project, for amplitudes a>0.3 mag. where the statistics appear to be complete allowing determination of Q(q) over 0.12<q<1, suggest a steep increase of Q(q) with q->0. The mass-ratio distribution can be approximated by a power law, either Q(q)~(1-q)^a1 with a1=6+/-2 or Q(q)~q^b1, with b1=-2+/-0.5, with a slight preference for the former form. Both forms must be modified by the theoretically expected cut-off caused by a tidal instability at about q_min 0.07-0.1. An expected maximum in Q(q), is expected to be mapped into a local maximum in A(a) around 0.2-0.25 mag.Comment: AASTeX5, 12 figures, 5 tables, accepted by AJ, Aug.200