Activation Energy of the Jahn-Teller Complexes in CaF2:Cu2+ Crystal

In CaF2 crystal doped with Cu^2+ ions, attenuation of all the normal ultrasonic modes with the wave vector k // were investigated at 22 -163 MHz in the temperature region of 4 - 200 K

STABILIZATION ENERGIES OF THE JAHN-TELLER COMPLEXES IN CaF2:Cr2+ CRYSTAL

In CaF2 crystal doped with Cr2+ ions, attenuation of all the normal ultrasonic modes with the wave vector k were investigated at 26 -158 MHz in the temperature region of 4 - 170 K. The observed peaks of relaxation origin were interpreted as manifestation of the Jahn-Teller effect

RELAXATION OF THE SYSTEM OF JAHN-TELLER COMPLEXES IN CdF2:Cr CRYSTAL

Anomalies in temperature dependence of ultrasound attenuation and velocity that are typical for the Jahn-Teller effect were observed in CdF2:Cr crystal. Parameters characterizing relaxation mechanism of the Jahn-Teller subsystem were determined.Финансирование. Работа выполнена при финансовой поддержке Российского научного фонда (проект № 22-22-00735)

Tunneling Relaxation in the System of Jahn-Teller Complexes in Fluorite Crystal Doped with Copper Ions

Temperature dependences of trigonal and tetragonal elastic moduli, have been studied in a fluorite crystal doped with copper ions at 56 MHz. The observed anomalies found at 24 K were considered as due to the Jahn-Teller effect.Research was supported by Russian Scientific Foundation (grant № 22-22-00735)

LOW-TEMPERATURE ATTENUATION OF ULTRASONIC WAVES BY JAHN-TELLER COMPLEXES IN A CaF2:Cr CRYSTAL

A new approach to setting up an ultrasonic experiment and data processing in studying the Jahn-Teller effect has been developed. It was found that in CaF2: Cr2+ in tunneling relax-ation mechanisms are dominant. The parameters characterizing the relaxation mechanisms are determined

A Noncoding RNA Modulator Potentiates Phenylalanine Metabolism in Mice

The functional role of long noncoding RNAs (lncRNAs) in inherited metabolic disorders, including phenylketonuria (PKU), is unknown. We demonstrated that the mouse lncRNA Pair and human HULC associate with phenylalanine hydroxylase (PAH). Pair-knockout mice exhibited excessive blood phenylalanine, musty odor, hypopigmentation, growth retardation, and progressive neurological symptoms including seizures, which faithfully models human PKU. HULC depletion led to reduced PAH enzymatic activities in human induced pluripotent stem cell (hiPSC)-differentiated hepatocytes. Mechanistically, HULC modulated the enzymatic activities of PAH by facilitating PAH-substrate and PAH-cofactor interactions. To develop a therapeutic strategy for restoring liver lncRNAs, we designed GalNAc-tagged lncRNA mimics that exhibit liver enrichment. Treatment with GalNAc-HULC mimics reduced excessive phenylalanine in Pair−/− and PahR408W/R408W mice and improved the phenylalanine tolerance of these mice