1,513 research outputs found
Experiments to Establish Current-carrying Capacity of Thermionic-emitting Cathodes Final Report, 11 Jan. 1966 - 30 Jan. 1967
Current carrying capabilities of thermionic cathodes in nitrogen at pressure levels above one atmospher
Non-equilibrium coherence dynamics of a soft boson lattice
We study the non-equilibrium evolution of the phase coherence of a
Bose-Einstein condensate (BEC) in a one dimensional optical lattice, as the
lattice is suddenly quenched from an insulating to a superfluid state. We
observe slowly damped phase coherence oscillations in the regime of large
filling factor (~100 bosons per site) at a frequency proportional to the
generalized Josephson frequency. The truncated Wigner approximation (TWA)
predicts the frequency of the observed oscillations.Comment: 10 pages. 4 figure
Extended Coherence Time with Atom-Number Squeezed Sources
Coherence properties of Bose-Einstein condensates offer the potential for
improved interferometric phase contrast. However, decoherence effects due to
the mean-field interaction shorten the coherence time, thus limiting potential
sensitivity. In this work, we demonstrate increased coherence times with number
squeezed states in an optical lattice using the decay of Bloch oscillations to
probe the coherence time. We extend coherence times by a factor of 2 over those
expected with coherent state BEC interferometry. We observe quantitative
agreement with theory both for the degree of initial number squeezing as well
as for prolonged coherence times.Comment: 4 pages, 4 figure
Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma in Older Adults
Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are plasma cell disorders of aging. The landscape of the diagnosis and management of MM and MGUS are rapidly changing. This article provides an updated understanding of the clinical presentation, evaluation, diagnosis, and management of older adults with MM and MGUS. Because most oncology providers are not formally trained in geriatric medicine, geriatricians play a key role in providing oncologists with a broader understanding of patient health status in the hope of improving outcomes for older adults with MM
Non-secretory multiple myeloma: from biology to clinical management
Multiple myeloma (MM) is the second most common hematologic malignancy in the US. It is typically characterized by production of large amounts of defective immunoglobulin (Ig). Diagnosing MM and monitoring treatment response, including eventual relapse, are largely based on sequential measurements of Ig. However, a small subset of MM called non-secretory multiple myeloma (NSMM) produces no detectable Ig. This subset of true NSMM has become even smaller over time, as the advent of the serum free light chain assay has resulted in the majority of NSMM patients being recategorized as light-chain MM – that is, MM cells that produce only the light-chain component of Ig. True forms of NSMM, meaning MM that secretes no monoclonal proteins whatsoever, constitute a distinct entity that is reviewed; definition of NSMM using current detection methods, discuss the biology underpinning NSMM development, and share recommendations for how NSMM should be managed clinically with respect to detection, treatment, and monitoring
Using AI/expert system technology to automate planning and replanning for the HST servicing missions
This paper describes a knowledge-based system that has been developed to automate planning and scheduling for the Hubble Space Telescope (HST) Servicing Missions. This new system is the Servicing Mission Planning and Replanning Tool (SM/PART). SM/PART has been delivered to the HST Flight Operations Team (FOT) at Goddard Space Flight Center (GSFC) where it is being used to build integrated time lines and command plans to control the activities of the HST, Shuttle, Crew and ground systems for the next HST Servicing Mission. SM/PART reuses and extends AI/expert system technology from Interactive Experimenter Planning System (IEPS) systems to build or rebuild time lines and command plans more rapidly than was possible for previous missions where they were built manually. This capability provides an important safety factor for the HST, Shuttle and Crew in case unexpected events occur during the mission
Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma
Although multiple myeloma remains incurable outside of allogeneic hematopoietic stem cell transplantation, novel agents made available only in the last few decades have nonetheless tremendously improved the landscape of myeloma treatment. Lenalidomide, of the immunomodulatory class of drugs, is one of those novel agents. In the non-transplant and relapsed/refractory settings, lenalidomide clearly benefits patients in terms of virtually all meaningful outcomes including overall survival. Data supporting the usage of lenalidomide as part of treatment approaches incorporating high-dose chemotherapy with autologous stem cell support (ASCT) are less mature as pertains to such long-term outcomes and toxicity, and lenalidomide is not currently approved by regulatory agencies for use in the context of ASCT in either the United States or Europe. That said, relatively preliminary efficacy data describing lenalidomide as a component of ASCT-based treatment approaches to MM are indeed promising, and consequently lenalidomide's role in ASCT-based treatment strategies is growing. In this review we summarize existing data that pertains to lenalidomide in the specific context of ASCT, and we share our thoughts on how our own group applies these data to approach this complex issue clinically
Biomass harvest of invasive Typha promotes plant diversity in a Great Lakes coastal wetland
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111287/1/rec12167.pd
Localization and Anomalous Transport in a 1-D Soft Boson Optical Lattice
We study the dynamics of Bose-Einstein condensed atoms in a 1-D optical
lattice potential in a regime where the collective (Josephson) tunneling energy
is comparable with the on-site interaction energy, and the number of particles
per lattice site is mesoscopically large. By directly imaging the motion of
atoms in the lattice, we observe an abrupt suppression of atom transport
through the array for a critical ratio of these energies, consistent with
quantum fluctuation induced localization. Directly below the onset of
localization, the frequency of the observed superfluid transport can be
explained by a phonon excitation but deviates substantially from that predicted
by the hydrodynamic/Gross-Pitaevskii equations.Comment: 14 pages, 5 figure
Bayesian estimation for selective trace gas detection
We present a Bayesian estimation analysis for a particular trace gas
detection technique with species separation provided by differential diffusion.
The proposed method collects a sample containing multiple gas species into a
common volume, and then allows it to diffuse across a linear array of optical
absorption detectors, using, for example, high-finesse Fabry-Perot cavities.
The estimation procedure assumes that all gas parameters (e.g. diffusion
constants, optical cross sections) are known except for the number population
of each species, which are determined from the time-of-flight absorption
profiles in each detector
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