234 research outputs found
Dynamic model and stationary shapes of fluid vesicles
A phase-field model that takes into account the bending energy of fluid
vesicles is presented. The Canham-Helfrich model is derived in the
sharp-interface limit. A dynamic equation for the phase-field has been solved
numerically to find stationary shapes of vesicles with different topologies and
the dynamic evolution towards them. The results are in agreement with those
found by minimization of the Canham-Helfrich free energy. This fact shows that
our phase-field model could be applied to more complex problems of
instabilities.Comment: Accepted for publication in EPJE. 9 pages, 7 figure
A First Step Towards Automatically Building Network Representations
To fully harness Grids, users or middlewares must have some knowledge on the
topology of the platform interconnection network. As such knowledge is usually
not available, one must uses tools which automatically build a topological
network model through some measurements. In this article, we define a
methodology to assess the quality of these network model building tools, and we
apply this methodology to representatives of the main classes of model builders
and to two new algorithms. We show that none of the main existing techniques
build models that enable to accurately predict the running time of simple
application kernels for actual platforms. However some of the new algorithms we
propose give excellent results in a wide range of situations
Large Scale Power Spectrum from Peculiar Velocities Via Likelihood Analysis
The power spectrum (PS) of mass density fluctuations, independent of
`biasing', is estimated from the Mark III catalog of peculiar velocities using
Bayesian statistics. A parametric model is assumed for the PS, and the free
parameters are determined by maximizing the probability of the model given the
data. The method has been tested using detailed mock catalogs. It has been
applied to generalized CDM models with and without COBE normalization.
The robust result for all the models is a relatively high PS, with at . An
extrapolation to smaller scales using the different CDM models yields . The peak is weakly constrained to the range
. These results are consistent with a direct
computation of the PS (Kolatt & Dekel 1996). When compared to galaxy-density
surveys, the implied values for () are of order
unity to within 25%.
The parameters of the COBE-normalized, flat CDM model are confined by a 90%
likelihood contour of the sort , where
and for models with and without tensor
fluctuations respectively. For open CDM the powers are and (no tensor fluctuations). A -shape model free of COBE
normalization yields only a weak constraint: .Comment: 19 pages, 8 figures, 2 tables. Accepted for publication in The
Astrophysical Journa
The ideal trefoil knot
The most tight conformation of the trefoil knot found by the SONO algorithm
is presented. Structure of the set of its self-contact points is analyzed.Comment: 11 pages, 8 figure
New Evidence for The Cosmological Origin of Gamma-Ray Bursts
We find that Gamma-ray bursts (GRBs) at the 3B catalog are correlated (at
95\% confidence level) with Abell clusters. This is the first known correlation
of GRBs with any other astronomical population. It confirms the cosmological
origin of GRBs. Comparison of the rich clusters auto-correlation with the
cross-correlation found here suggests that \sim 26 \pm 15\% of an accurate
(\delta<2.3 deg.) position GRBs sub-sample members are located within 600
\hmpc.Comment: 10 Pages, figures included, uuencoded gzipped ps-fil
Translational control of recombinant human acetylcholinesterase accumulation in plants
<p>Abstract</p> <p>Background</p> <p>Codon usage differences are known to regulate the levels of gene expression in a species-specific manner, with the primary factors often cited to be mRNA processing and accumulation. We have challenged this conclusion by expressing the human acetylcholinesterase coding sequence in transgenic plants in its native GC-rich sequence and compared to a matched sequence with (dicotyledonous) plant-optimized codon usage and a lower GC content.</p> <p>Results</p> <p>We demonstrate a 5 to 10 fold increase in accumulation levels of the "synaptic" splice variant of human acetylcholinesterase in <it>Nicotiana benthamiana </it>plants expressing the optimized gene as compared to the native human sequence. Both transient expression assays and stable transformants demonstrated conspicuously increased accumulation levels. Importantly, we find that the increase is not a result of increased levels of acetylcholinesterase mRNA, but rather its facilitated translation, possibly due to the reduced energy required to unfold the sequence-optimized mRNA.</p> <p>Conclusion</p> <p>Our findings demonstrate that codon usage differences may regulate gene expression at different levels and anticipate translational control of acetylcholinesterase gene expression in its native mammalian host as well.</p
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