A convenient synthesis of 2-fluoro-ɑ-methyl[1,1'-biphenyl]-4-acetic acid via rearrangement of aryl ketones

239-24

Regio- and stereoselective hydrogenolysis of optically active diols via transfer hydrogenation: Synthesis of ɑ-arylpropionic acids

1221-122

A short and enantioselective synthesis of (<i>S</i>)-<i>N</i>-tosyl-l-naphthylglycine

291-293Synthesis of (S)-N-tosyl-1-naphthylglycine with good optical purity was achieved using Sharpless asymmetric aminohydroxylation as key step

Cu-exchanged Y-zeolite: A heterogeneous catalyst for the synthesis of α-aminoketones

515-517Cu-zeolite catalyzes the amination of silyl enol ethers using PhI= NTs producing α-amino ketones in good yields

Enantioselective synthesis of (<i style="">S</i>)-<i style=""><img src='/image/spc_char/alpha.gif' border=0></i>-arylpropionic acids <i style="">via</i> Pd-catalyzed kinetic resolution of benzylic alcohols

557-562A convenient synthetic route for the synthesis of three (S)-a-propionic acids, (S)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (S)-phenylpropionic acid (92% ee) is described. Pd-catalyzed oxidative kinetic resolution of the corresponding benzylic alcohols is used as a key step to introduce stereogenicity into the molecule

Neodymium acetylacetonate. A new heterogeneous catalyst for transfer hydrogenation of carbonyl compounds

409-410Neodymium acetylacetonate, Nd (acac)3 3H2O, has been found to exhibit high activity towards the transfer hydrogenation of carbonyl compounds using 2-propanol as hydrogen source under truly heterogeneous phase to afford the corresponding alcohols in 63-81% yield

<span style="font-size:19.5pt;mso-bidi-font-size:14.5pt">Regio and stereoselective opening of chiral cyclic sulfates with MgBr_{<span style="font-size: 20.5pt;mso-bidi-font-size:14.5pt">2</span>}<span style="font-size:19.5pt; mso-bidi-font-size:14.5pt">-Et_{<span style="font-size:14.0pt; mso-bidi-font-size:9.0pt">2</span>}<span style="font-size:19.5pt; mso-bidi-font-size:14.5pt">O: <span style="font-size:19.5pt;mso-bidi-font-size:14.5pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">A practical strategy for the synthesis of <i><span style="font-size:19.0pt;mso-bidi-font-size:14.0pt;font-family:Arial;mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US; mso-bidi-language:AR-SA">(2R,</span></i><span style="font-size:19.0pt; mso-bidi-font-size:14.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA; mso-bidi-font-style:italic">3<i>S)-</i>(<span style="font-size:19.0pt; mso-bidi-font-size:14.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">-<span style="font-size:19.5pt;mso-bidi-font-size:14.5pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">)-<i style="mso-bidi-font-style:normal">N</i>-benzoyl-3-phenylisoserine ethyl ester (taxol side chain)</span></span></span></span></span></span></span>

283-286<span style="font-size:13.5pt;mso-bidi-font-size:8.5pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">The reaction of 4(S)-carbethoxy-5(R)-phenyl-1,3,2-dioxathiolane-2,2-dioxide <span style="font-size:14.0pt; mso-bidi-font-size:9.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="">4<span style="font-size:14.0pt;mso-bidi-font-size: 9.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"=""> with MgBr2.Et2O <span style="font-size:13.5pt; mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="">readily proceed regio- and stereoselectively at the benzylic position to afford the desired bromohydrin <b style="mso-bidi-font-weight: normal"><span style="font-size:14.0pt;mso-bidi-font-size:9.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">5 <span style="font-size:13.5pt; mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="">in excellent yield which led to an improved process for the synthesis of (2<span style="font-size:15.0pt;mso-bidi-font-size: 13.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">R, <span style="font-size:13.5pt; mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="">3S)-( -)-N-benzoyl-3-phenylisoserine ethyl ester <span style="font-size:13.0pt;mso-bidi-font-size: 8.0pt;font-family:Arial;mso-fareast-font-family:" times="" new="" roman";mso-ansi-language:="" en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">8<span style="font-size:13.0pt;mso-bidi-font-size:8.0pt;font-family:Arial;mso-fareast-font-family: " times="" new="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"=""> <span style="font-size:13.5pt;mso-bidi-font-size: 8.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">(taxol <span style="font-size:13.0pt;mso-bidi-font-size:8.0pt;font-family:Arial; mso-fareast-font-family:" times="" new="" roman";mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="">C13<span style="font-size:14.0pt; mso-bidi-font-size:9.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"=""> <span style="font-size:13.5pt;mso-bidi-font-size: 8.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">side chain) in excellent yield and optical purity.</span