The role of carbon dioxide (and intracellular pH) in the pathomechanism of several mental disorders: Are the diseases of civilization caused by learnt behaviour, not the stress itself? [A széndioxid (és az intracelluláris pH) szerepe néhány mentális betegség patomechanizmusában: Nem maga a stressz, hanem tanult viselkedési formák okoznák a civilizációs betegségeket?]

The role of carbon dioxide (CO2) is underestimated in pathomechanism of neuropsychiatric disorders, though it is an important link between psyche and corpus. The actual spiritual status also influences respiration (we start breathing rarely, frequently, irregularly, etc.) causing pH alteration in organism; on the other hand the actual cytosolic pH of neurones is one of the main modifiers of Ca2+-conductance, hence breathing directly, quickly, effectively influences second messenger system through Ca2+-currents. (Decreasing pCO2 turns pH into alkalic direction, augments psychic arousal, while increasing pCO2 turns pH acidic, diminishes arousal.) One of the most important homeostatic function is to maintain or restore the permanence of H+-concentration, hence alteration of CO2 level starts cascades of contraregulation. However it can be proved that there is no perfect compensation, accordingly compensational mechanisms may generate psychosomatic disorders causing secondary alterations in "milieu interieur". Authors discuss the special physico-chemical features of CO2, the laws of interweaving alterations of pCO2 and catecholamine levels (their feedback mechanism), the role of acute and chronic hypocapnia in several hyperarousal disorders (delirium, panic disorder, hyperventilation syndrome, generalized anxiety disorder, bipolar disorder), the role of "locus minoris resistentiae" in pathomechanism of psychosomatic disorders. It is supposed that the diseases of civilization are caused not by the stress in itself but the lack of human instinctive reaction to it, and this would cause long-lasting CO2 alteration. Increased brain-pCO2, acidic cytosol pH and/or increased basal cytosolic Ca2+ level diminish inward Ca 2+-current into cytosol, decrease arousal - they may cause dysthymia or depression. This state usually co-exists with ATP-deficiency and decreased cytosolic Mg2+ content. This energetical-and ion-constellation is also typical of ageing-associated and chronic organic disorders. It is the most important link between depression and organic disorders (e.g. coronary heart disease). The above-mentioned model is supported by the fact that H+ and/or Ca2+ metabolism is affected by several drugs (catecholemines, serotonin, lithium, triaecetyluridine, thyroxine) and sleep deprivation, they act for the logically right direction

NOMAD: A distributed web-based platform for managing materials science research data

NOMAD lets you manage and share your materials science data in a way that makes it truly useful to you, your group, and the community. Materials science research is becoming increasingly data-driven, which requires more effort to manage, share, and publish data. NOMAD is a web-based application that provides data management for materials science research data. In addition to core data management functions like uploading and sharing files, NOMAD allows structured data entry using customizable forms providing the software with electronic laboratory notebook (ELN) functionalities. It automatically extracts rich metadata from supported file formats, normalizes and converts data from these formats, and provides a faceted search with materials science-specific filters based on extracted metadata. NOMAD integrates data analysis and machine learning tools. Installations of NOMAD can be connected to share data between research institutes and can publish data to an open central NOMAD service. The NOMAD software is distributed as a Docker image to create data management services and as a Python package to automate the client's use of these services