Study of the pathogenesis and diagnosis of ulcer of lower extremity under various conditions

Background: As lower extremities are exposed to injury and having a circulation strained by upright posture of human being should be the site of ulcer. This has reason for researchers and surgeon who have been concerned with the reasons for their common occurrence and difficulty in their cure. Researcher interested to study the pathogenesis of ulcer of lower extremity under various conditions.Methods: In the present study, 70 patients of lower extremity ulcer with various types were admitted in surgical wards of Mallareddy Institute of Medical Sciences, Hyderabad. The cases were examined in detail and investigated thoroughly. In clinically doubtful cases, the diagnosis was made only after histopathological examination.Results: Most common type of ulcer was found in the present was Venous 13 (18.57%) cases, contributed by male (12) and female (1) followed by Traumatic 12 (17.14%) and Diabetic 11 (15.74%). Most of cases belong to the age group 41-60 years (47.14) and male (28 cases). High saphenous vein ligation with sripping of veins (23.07%) and conservative (23.07%) treatment were common surgical procedures used for the treatment of venous ulcer.Conclusions: In the present, venous ulcers are the most common of all leg ulcers with high morbidity. The surgical procedures are directed at prevention of venous reflux at various levels

The Power Flow Angle of Acoustic Waves in Thin Piezoelectric Plates

The curves of slowness and power flow angle (PFA) of quasi-antisymmetric (A0) and quasi-symmetric (S0) Lamb waves as well as quasi-shear-horizontal (SH0) acoustic waves in thin plates of lithium niobate and potassium niobate of X-,Y-, and Z-cuts for various propagation directions and the influence of electrical shorting of one plate surface on these curves and PFA have been theoretically investigated. It has been found that the group velocity of such waves does not coincide with the phase velocity for the most directions of propagation. It has been also shown that S0 and SH0 wave are characterized by record high values of PFA and its change due to electrical shorting of the plate surface in comparison with surface and bulk acoustic waves in the same material. The most interesting results have been verified by experiment. As a whole, the results obtained may be useful for development of various devices for signal processing, for example, electrically controlled acoustic switchers

Periodicity of combined heat transfer from horizontal cylinders

CER72-73SKN-VAS23.March 1973.Includes bibliographical references (pages 46-48).Prepared under Office of Naval Research Contract No. N00014-68-A-0493-0001, Project No. NR 062-414/6-6-68(Code 438), U. S. Department of Defense.Circulating copy deaccessioned 2020.Based on experimental and flow visualization studies, a model for directly opposed free and forced convection flow around a heated cylinder (0.01 mm diameter) was developed. Three modes of flow were identified. For velocities less than 15 cm/sec (cylinder Reynolds number, Redw=0.08) a free convection or a buoyant force dominated flow was observed. The interacting free convection plume and the ambient flow form a stagnation region well upstream of the heated cylinder. Heat was convected from the cylinder through the plume to the stagnation region. In the stagnation region random vortex pockets of heated mass were formed. For velocities greater than 15 cm/sec but less than 21.4 cm/sec the magnitudes of the forced and free convection flows were nearly equal. A periodic oscillation of the stagnation region was observed. The flow regime where the periodic oscillations occur was found to be defined by a specific relation between the Grashof and Reynolds numbers. The periodic oscillations, which were in the range from 3 to 15 cycles per minute, were correlated in terms of Strauhal number and Reynolds number. For velocities greater than 21.4 cm/sec the forced convection was found to dominate over the free convection. The stagnation region was fixed for each flow velocity at one position above the cylinder. A potential like flow (laminar sheet) was formed shrouding the thermal layer of the cylinder. The mean heat transfer from the cylinder decreases with increasing Reynolds number for both the case of dominant free convection and the case of equal free and forced convection. The mean heat transfer abruptly and rapidly increases with increasing Reynolds number in the forced convection dominated region. For all these cases the thermal layer surrounding the hot cylinder was approximately 600 times larger than the diameter of the cylinder

IMMEDIATE RELEASE SOLID DISPERSION TABLET OF AZILSARTAN: FORMULATION STRATEGY TO ENHANCE ORAL BIOAVAILABILITY

Objective: Objective of the present study was to develop an immediate release solid dispersion tablet to enhance oral bioavailability of Azilsartan. Methods: Solid dispersion of azilsartan was developed using Soluplus® as a novel solubility enhancer by the solvent evaporation technique. 32factorial design was used in a fully randomized order to study effect of amount of azilsartan and Soluplus on solubility (µg/ml) and % drug dissolved in 30 min. Prepared solid dispersion was evaluated for different micromeritic properties, saturation solubility, and wettability. Then solid dispersion of all the batches compressed into an immediate-release tablet using sodium starch glycolate as a super disintegrant. Developed tablet formulations were evaluated for various post-compression parameters and satisfactory formulation among these were further studied for Fourier-transform infrared spectroscopy (FTIR), Differential Scanning Colorimeter (DSC), X-Ray Diffraction (XRD), in vivo absorption and stability study. Results: Results of micromeritic properties of solid dispersion showed that good flowability, compressibility, wettability, and saturation solubility. Post compression parameters of immediate-release tablets were found to be in acceptable limits. Batch ASD2 containing 40 mg Diacerein and 80 mg of Soluplus showed maximum drug release i.e. 99.82 % within 30 min. Compatibility study using FTIR, DSC, and XRD showed that drug is compatible with Soluplus. In vivo absorption study showed that, 2.67 fold increase in Area Under Curve (AUC) as compared to plain Azilsartan. Relative bioavailability was found to be 267.11 %. Results of stability study indicate that developed formulations were stable at accelerated temperature and humidity conditions. Conclusion: Study concluded that solid dispersion using Soluplus as a solubility enhancer is a suitable formulation strategy to enhance solubility, dissolution, and bioavailability of poorly water-soluble drug-like Azilsartan

DEVELOPMENT OF SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM OF DIACEREIN FOR ENHANCED DISSOLUTION RATE

Objective: The objective of the present study was to develop solid self-microemulsifying drug delivery system (S-SMEDDS) of diacerein (DCN) for enhancement of dissolution rate. Methods: Three batches of liquid SMEDDS were prepared using oleic acid, Tween 80, and polyethylene glycol 200 as oil, surfactant, and cosurfactant, respectively. Microemulsion region was recognized by constructing a pseudoternary phase diagram containing a different proportion of oil, surfactant, and cosurfactant. Prepared liquid SMEDDS was evaluated for thermodynamic stability study, dispersibility tests, globule size, zeta potential, and viscosity. Liquid SMEDDS was then converted to S-SMEDDS by adsorption technique using Neusilin US2 as a solid carrier. Prepared S-SMEDDS was evaluated for different micromeritic properties, drug content, reconstitution properties, in vitro dissolution study, Fourier transform infrared, and scanning electron microscopy. Results: The results showed that all batches of liquid SMEDDS were found to be thermodynamically stable. Reconstitution properties of S-SMEDDS showed spontaneous microemulsification with globule size 0.271 μm and −16.18 mV zeta potential. From the results of in vitro dissolution study, it was found that the release of DCN was significantly increased as compared with plain DCN. Conclusion: The study concluded that dissolution rate of poorly water-soluble drug like DCN can be increased by developing S-SMEDDS formulation

The Outer Halo of the Milky Way as Probed by RR Lyr Variables from the Palomar Transient Facility

RR Lyr stars are ideal massless tracers that can be used to study the total mass and dark matter content of the outer halo of the Milky Way. This is because they are easy to find in the light curve databases of large stellar surveys and their distances can be determined with only knowledge of the light curve. We present here a sample of 112 RR Lyr beyond 50 kpc in the outer halo of the Milky Way, excluding the Sgr streams, for which we have obtained moderate resolution spectra with Deimos on the Keck 2 Telescope. Four of these have distances exceeding 100 kpc. These were selected from a much larger set of 447 candidate RR Lyr which were datamined using machine learning techniques applied to the light curves of variable stars in the Palomar Transient Facility database. The observed radial velocities taken at the phase of the variable corresponding to the time of observation were converted to systemic radial velocities in the Galactic standard of rest. From our sample of 112 RR Lyr we determine the radial velocity dispersion in the outer halo of the Milky Way to be ~90 km/s at 50 kpc falling to about 65 km/s near 100 kpc once a small number of major outliers are removed. With reasonable estimates of the completeness of our sample of 447 candidates and assuming a spherical halo, we find that the stellar density in the outer halo declines as the -4 power of r.Comment: Accepted for publication in the Ap

Prevalence of self-medication and its pattern in medical students: a cross sectional study from Karnataka

Background: Self-medication is becoming a common type of self-care behavior among the population of many countries. Obtaining and consuming drugs without the advice of physician either for diagnosis, prescription or surveillance is called self-medication. The objectives of the study were to study prevalence and existing pattern of self-medication and its determinants among the medical students.Methods: A cross sectional descriptive study was conducted involving 200 medical students by systemic random sampling method using pretested semi-structured proforma. Analysis was done using SPSS and results were presented. Chi square and odds ratio (OR) was used as statistical tool.Results: Out of 200 students, 66.5% students were from 22-24 years of age group (mean age 20.2±1.4 years, p0.05). Majority of the students (95.2%) were self-medicating with allopathy drugs. 51.6% responded that they were getting quick relief with self-medication. 82% were aware about the possible adverse effects (OR 0.5, p>0.05). Self-medication was practiced by 78% students for upper respiratory tract infection, headache (70%), fever (67.7%) and gastrointestinal upset (36%). Majority (83%) students consumed paracetamol tablet for various health related reasons followed by cough syrups (55.3%), nonsteroidal anti-inflammatory drugs (54.3%), antibiotics (23.1%).Conclusions: Prevalence of self-medication was high in spite of awareness of possible adverse effects amongst students. Also, the knowledge of selection of appropriate drug for self-medication was observed to be poor

A New Large Super-Fast Rotator: (335433) 2005 UW163

Asteroids of size larger than 150 m generally do not have rotation periods smaller than 2.2 hours. This spin cutoff is believed to be due to the gravitationally bound rubble-pile structures of the asteroids. Rotation with periods exceeding this critical value will cause asteroid breakup. Up until now, only one object, 2001 OE84, has been found to be an exception to this spin cutoff. We report the discovery of a new super-fast rotator, (335433) 2005 UW163, spinning with a period of 1.290 hours and a lightcurve variation of $r'\sim0.8$ mag from the observations made at the P48 telescope and the P200 telescope of the Palomar Observatory. Its $H_{r'} = 17.69 \pm 0.27$ mag and multi-band colors (i.e., $g'-r' = 0.68\pm0.03$ mag, $r'-i' = 0.19\pm0.02$ mag and SDSS $i-z = -0.45$ mag) show it is a V-type asteroid with a diameter of $0.6 +0.3/-0.2$ km. This indicates (335433) 2005 UW163 is a super-fast rotator beyond the regime of the small monolithic asteroid.Comment: 18 pages, 4 figures, 1 table Accepted by ApJ

A novel method for transient detection in high-cadence optical surveys: Its application for a systematic search for novae in M31

[abridged] In large-scale time-domain surveys, the processing of data, from procurement up to the detection of sources, is generally automated. One of the main challenges is contamination by artifacts, especially in regions of strong unresolved emission. We present a novel method for identifying candidates for variables and transients from the outputs of such surveys' data pipelines. We use the method to systematically search for novae in iPTF observations of the bulge of M31. We demonstrate that most artifacts produced by the iPTF pipeline form a locally uniform background of false detections approximately obeying Poissonian statistics, whereas genuine variables and transients as well as artifacts associated with bright stars result in clusters of detections, whose spread is determined by the source localization accuracy. This makes the problem analogous to source detection on images produced by X-ray telescopes, enabling one to utilize tools developed in X-ray astronomy. In particular, we use a wavelet-based source detection algorithm from the Chandra data analysis package CIAO. Starting from ~2.5x10^5 raw detections made by the iPTF data pipeline, we obtain ~4000 unique source candidates. Cross-matching these candidates with the source-catalog of a deep reference image, we find counterparts for ~90% of them. These are either artifacts due to imperfect PSF matching or genuine variable sources. The remaining ~400 detections are transient sources. We identify novae among these candidates by applying selection cuts based on the expected properties of nova lightcurves. Thus, we recovered all 12 known novae registered during the time span of the survey and discovered three nova candidates. Our method is generic and can be applied for mining any target out of the artifacts in optical time-domain data. As it is fully automated, its incompleteness can be accurately computed and corrected for.Comment: 16 pages, 8 figures, accepted to A&