Synthesis and biological evaluation of immunoconjugates of adriamycin and a human IgM linked by poly[N5-(2-hydroxyethyl)-l-glutamine

The synthesis and purification of radiolabelled immunoconjugates, composed of a human IgM monoclonal antibody (IgM 16.88) directed against an intracellular tumour-associated antigen, the drug carrier poly[N5-(2-hydroxyethyl)--glutamine] (PHEG) and the cytostatic drug adriamycin (ADR) are described. The immunoconjugates were constructed to allow selective release of ADR in the putatively acidic environment of the tumour through a novel acid-labile maleamic acid linker. The conjugate of PHEG and the acid-labile ADR derivative effectively released ADR in cytotoxic amounts at a pH of 6.0 as judged from incubation in buffer and from inhibition of the growth of HT-29 colon tumour cells in vitro. Immunoconjugates were prepared by coupling of PHEG-ADR having a hydrolytically stable amide bond with 131I-labelled antibody through thioether bond formation involving a single thiol group at the C-terminus of the polymer chain and maleimido groups introduced onto th

Adiabatic normal zone development in MgB2 superconductors

A-priori knowledge of the normal zone development in MgB/sub 2/ conductors is essential for quench protection of applications. Therefore the normal zone propagation in a monofilament MgB/sub 2//Fe conductor under near-adiabatic conditions at 4.2 K has been measured and simulated. The results show normal zone propagation velocities up to several meters per second. In addition, by including the voltage-current relation into the computational model, the influence of the n-value on the normal zone propagation is determined. The simulations show that lower n-values suppress the normal zone propagation velocity due to lower heat generation in the MgB/sub 2/ filaments

Charge Transfer Of Hydrogen Ions And Atoms In Metal Vapors

Cross sections and equilibrium fractions for energetic H+, H−, and H0 in collisions with metal vapor targets have been compiled and evaluated. Both experimental and theoretical results are reported. Sources of errors are discussed, and recommended values for the data are presented. © 1985, American Institute of Physics for the National Institute of Standards and Technology. All rights reserved

High transport currents in mechanically reinforced MgB2 wires

We prepared and characterized monofilamentary MgB2 wires with a mechanically reinforced composite sheath of Ta(Nb)/Cu/steel, which leads to dense filaments and correspondingly high transport currents up to Jc = 10^5 A/cm^2 at 4.2 K, self field. The reproducibility of the measured transport currents was excellent and not depending on the wire diameter. Using different precursors, commercial reacted powder or an unreacted Mg/B powder mixture, a strong influence on the pinning behaviour and the irreversibility field was observed. The critical transport current density showed a nearly linear temperature dependency for all wires being still 52 kA/cm^2 at 20 K and 23 kA/cm^2 at 30 K. Detailed data for Jc(B,T) and Tc(B) were measured.Comment: 21 pages, 13 figures, revised version, to be published in Supercond. Sci. Techno

Test of a DC-HTS Busbar Demonstrator for Power Distribution in Hybrid-Electric Propulsion Systems for Aircraft

In the framework of the German project TELOS (Thermo-Electrically Optimised Aircraft Propulsion Systems) a high-temperature superconducting 40 MVA DC demonstrator busbar for hybrid-electric propulsion systems for aircraft has been developed. The design current for a temperature below 25 K is 13.3 kA and the rated voltage is 3 kV. The 2-pole busbar contains 2 stacks of REBCO coated conductors which are supported by a 3D-printed structure allowing compensation of thermal length changes of the superconductor. It fits in a cryostat tube with an inner diameter of 25 mm. A special focus has been put on low-resistive joints that are necessary to connect single elements of the busbar system. The special layout of the joints allows an effective current redistribution between the different tapes in a stack. We present results for the test of the DC busbar demonstrator in liquid nitrogen at 77 K. The design current for this temperature is 3.3 kA which corresponds to a rated power of 10 MW. We applied currents up to 3.5 kA and measured the I-V characteristics and contact resistances of 90° and 180° joints in a virgin and in a strained state thus simulating thermal length changes. We also present results of Lorentz-Force tests with short AC current pulses up to 20 kA to demonstrate the viability of the design for application with currents up to 13.3 k