Reproducibility of quantitative F-18-3'-deoxy-3'-fluorothymidine measurements using positron emission tomography

Positron emission tomography (PET) using F-18-3'-deoxy-3'-fluorothymidine ([F-18]FLT) allows noninvasive monitoring of tumour proliferation. For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [F-18]FLT measurements. Nine patients with non-small-cell lung cancer (NSCLC) and six with head-and-neck cancer (HNC) underwent [F-18]FLT PET twice within 7 days prior to therapy. The maximum pixel value (SUVmax) and a threshold defined volume (SUV41%) were defined for all delineated lesions. The plasma to tumour transfer constant (K-i) was estimated using both Patlak graphical analysis and nonlinear regression (NLR). NLR was also used to estimate k(3), which, at least in theory, selectively reflects thymidine kinase 1 activity. The level of agreement between test and retest values was assessed using the intraclass correlation coefficient (ICC) and Bland-Altman analysis. All primary tumours and > 90% of clinically suspected locoregional metastases could be delineated. In total, 24 lesions were defined. NLR-derived K-i, Patlak-derived K-i, SUV41% and SUVmax showed excellent reproducibility with ICCs of 0.92, 0.95, 0.98 and 0.93, and SDs of 16%, 12%, 7% and 11%, respectively. Reproducibility was poor for k(3) with an ICC of 0.43 and SD of 38%. Quantitative [F-18]FLT measurements are reproducible in both NSCLC and HNC patients. When monitoring response in individual patients, changes of more than 15% in SUV41%, 20-25% in SUVmax and Patlak-derived K-i, and 32% in NLR3k-derived K-i are likely to represent treatment effect

Transfer of innovative policies between cities to promote sustainability case study evidence

This paper describes how cities approach the challenging task of identifying, considering, and adopting innovative transport policies. Drawing on political science literature, the paper begins by establishing a framework for analyzing the process of policy transfer and policy learning. Cities were selected on the basis of their reputation for having adopted innovative policies. Data were collected from project reports and in-depth interviews with 40 professionals comprising planners, consultants, and operators in 11 cities across North America and northern Europe. This paper presents the findings from three key innovations: congestion charging, compact growth and transport planning, and carsharing. Each of these innovations was implemented at several sites, and there was evidence of learning across the sites studied. The case studies present a discussion of each policy alongside indications of its positive and negative impacts and then examine how the different cities approached the task of learning about how to introduce it and the issues that they faced. The paper identifies conditions that appear to support effective learning: reliance on strong networks of personal and professional contacts, drawing lessons from multiple sites, and financial and institutional support to facilitate the uptake of risky or technologically immature innovations

Beyond the deliberative subject? Problems of theory, method and critique in the turn to emotion and affect

This paper explores some of the issues for policy scholars arising from the increasing attention paid to ‘emotion’ and ‘affect’ in contemporary social science. One such issue is in the focus placed on detailed ethnographic methods and interpretive forms of analysis, and the problem this raises for drawing out connections to changing regimes of governing and wider shifts in policy and politics. A second lies in the modernist traditions of policy studies, traditions which privilege the rational actor and deliberative subject. This paper uses my own recent research to tease out some issues of method and of theory in conducting a research project that seeks to connect individual working lives to some of the major cultural and social change in Britain over the last 60 years. The paper begins by outlining the project and some of the issues raised in interpreting ‘emotion’, then goes on to show how I tried to link ethnographic data to wider questions of policy and power. The final section offers two different critical repertoires that have the capacity to link emotions and emotion work to analysis of shifting governmentalities and material conditions of work. Throughout my aim is to enhance the possibility of interdisciplinary conversations by introducing concepts and analytical framings from beyond the traditions of policy studies